Parathyroid Disorders

Hendy, Geoffrey N.

doi:10.1016/b978-0-12-383834-6.00089-6

Cited by 1 publication

(1 citation statement)

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“…Though, intriguingly, CaSR sites can be found throughout the body including the brain, intestines, bone marrow, pancreas, and eyes. Such a finding lends credence to an understanding of extracellular calcium as central to parenchymal function across the body [ 6 - 8 ]. Intriguingly, genetic defects in the CaSRs are implicated in a range of calcemic disorders and may be investigated upon presentation with hypo- or hypercalcemia after the diagnosis of secondary malignancy, primary parathyroid dysfunction, or vitamin D deficiency has been ruled out [ 7 , 8 ].…”

Section: Abundance and Regulatory Functionmentioning

confidence: 83%

Calcium: More Than Bone? Implications for Clinical Practice and Theory

Hands

Moy

2021

J Clin Med Res

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Serum calcium is routinely screened, but rarely scrutinized in the context of normal, physiologic functioning. This brief review strives to explore the implications of serum calcium, suggests guidelines for its interpretation, and discusses the implications of high, low, and “normocalcemia” in the clinical setting. We find that serum Ca 2+ concentrations are a valuable prognostic indicator in routine metabolic workups and advocate for greater attention, on behalf of the provider, to variations in a patient’s calcemic status. Variations in calcemic status are primarily tied to malignancy, impaired parathyroid hormone (PTH) secretion, defects in vitamin D synthesis, insulin-like growth factor 1 (IGF-1) fluctuation, genetic syndromes (DiGeorge syndrome) and calcium-sensing receptor ( CaSR ) mutation. Prognostic implications for high and low serum Ca 2+ include, but are not limited to, increased thromboembolic and major adverse cardiovascular event (MACE) risk, cardiac remodeling, hypertension, cognitive decline, and insulin resistance.

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