Calcium: More Than Bone? Implications for Clinical Practice and Theory

Hands, Jacob M; Moy, Lawrence S.

doi:10.14740/jocmr4505

Cited by 6 publications

(4 citation statements)

References 27 publications

(64 reference statements)

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“…Furthermore, there is activation of vitamin D with consequent increase in intestinal reabsorption and decrease in renal calcium excretion [2]. On the other hand, when the concentration of Ca in the ECF increases, PTH decreases, and Ca deposition occurs in bones [12].…”

Section: Calcium Absorption and Metabolismmentioning

confidence: 99%

Calcium, adolescence and puberty

Ciampo¹,

Ciampo²

2023

World J. Adv. Res. Rev.

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Adolescence is a phase of life characterized by major physical, emotional, social, and cultural changes. In this period, the puberty process stands out, and due to the action of several hormones, great changes are observed in body structure. For all these changes to occur, it is necessary for adolescents to consume nutrients in sufficient quantity and quality to meet the body's demands. One of the most important micronutrients at this stage of life is calcium, involved in several metabolic and structural processes, and which must be ingested daily through an adequate diet. This article discusses the role of calcium in adolescent growth and development, considering metabolic and clinical characteristics, highlighting the importance of this micronutrient for the current and future health of adolescents.

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Section: Calcium Absorption and Metabolismmentioning

confidence: 99%

Calcium, adolescence and puberty

Ciampo¹,

Ciampo²

2023

World J. Adv. Res. Rev.

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“…Круг замыкается. Следствием этого хорошо отрегулированного механизма является восстановление адекватной концентрации кальция в крови [1,5,6].…”

Section: гомеостаз кальцияunclassified

Hypercalcemia syndrome: differential diagnostic search and treatment tactics

Demidova

Lobanova

Korotkova

2023

jour

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Hypercalcemia is a common laboratory finding. The most common causes of high blood calcium are primary hyperparathyroidism, tertiary hyperparathyroidism, parathyroid cancer, malignant neoplasms, long-term therapy with lithium and thiazide diuretics, vitamin D intoxication, which require a different approach to treatment. Therefore, it is important for a doctor to be able to conduct a differential diagnostic search for hypercalcemia syndrome in order to establish the cause of high blood calcium and determine the correct tactics for managing patients.

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“…The identification of such biomarkers could better assist practitioners in assessing the prognosis of patients undergoing operation. As a widespread secondary messenger within multiple intracellular signaling pathways, calcium is involved in the bone turnover and a myriad of vital cellular activities including proliferation, motility and apoptosis, suggesting that calcium plays an important role in tissue regeneration and parenchymal function across the body [ 14 ]. In recent years, serum calcium level has been used to help determine the prognosis of cardiovascular event, cognitive decline and cancer [ 15 – 17 ].…”

Section: Introductionmentioning

confidence: 99%

Preoperative serum calcium could be a prognostic factor for surgical treatment of recurrent patellar dislocation: a retrospective study

Qiao

et al. 2022

BMC Musculoskelet Disord

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Background Surgical treatment for recurrent patellar dislocation (RPD) could yield good outcomes. While, unsatisfactory recovery still exists in some cases. For all prognostic factors, serum biomarkers have rarely been investigated. This study aimed to evaluate the prognostic value of preoperative serum calcium level, a widely used serum biomarker, in surgical treatment for RPD. Study design Retrospective study. Methods Ninety-nine patients with RPD were enrolled in the study. Preoperative serum calcium was acquired from routinely tested blood 1 day prior to operation. Demographic data, characteristics of RPD, postoperative functional outcomes were obtained. The association between preoperative calcium and postoperative functional outcomes (Kujala, Lysholm, Tegner, IKDC and KOOS score) was determined by correlation analysis and multivariate linear regression analysis. Poor recovery was determined as Kujala score below 80. The receiver operating characteristic (ROC) curve was used to assess the prognostic value of preoperative calcium. Results Patients were followed up for a mean period of 2.45 ± 1.33 years. All clinical scores showed significant improvement at the latest follow-up. Correlation and multivariate linear analyses indicated that serum calcium level was an important factor related with the prognosis of surgical treatment for RPD. According to the ROC curve, the cut-off value for preoperative calcium was 2.225 mmol/L. The clinical outcomes of patients with a preoperative blood calcium < 2.225 mmol/L was significantly worse than that with a higher calcium level. The correspondent sensitivity was 0.812 with a specificity of 0.633. Conclusion Operative treatment for RPD achieved good results, while in some cases the functional scores remain inferior. As a serum biomarker, preoperative calcium could be prognostic for outcomes after surgical treatment for RPD.

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Calcium: More Than Bone? Implications for Clinical Practice and Theory

Cited by 6 publications

References 27 publications

Calcium, adolescence and puberty

Calcium, adolescence and puberty

Hypercalcemia syndrome: differential diagnostic search and treatment tactics

Preoperative serum calcium could be a prognostic factor for surgical treatment of recurrent patellar dislocation: a retrospective study

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