Parathyroid carcinoma and oxyphil parathyroid adenoma: an uncommon case of misinterpretation in clinical practice

Dytz, Márcio Garrison; Lázaro, Ana Paula Pires; Gonçalves, Marta; Vidal, Ana Paula Aguiar; Teixeira, Patrícia de Fátima dos Santos; Farias, Maria Lúcia Fleiuss

doi:10.1507/endocrj.ej12-0358

Cited by 3 publications

(37 citation statements)

References 39 publications

(81 reference statements)

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“…The prevalence of PC is estimated to be less than 1% of cases of primary hyperparathyroidism, and incidence from 3.5 to 5.73 per 10 million has been reported [3][4][5][6]. However, in Japan and in Italy this cancer is more prevalent compared to other Western countries, concerning about 5% of subjects with hyperparathyroidism [9,16,17].…”

Section: Epidemiology Of Parathyroid Carcinomamentioning

confidence: 99%

“…Additionally, SPECT/CT (singlephoton emission computed tomography/ computed PRACE POGLĄDOWE tomography) may be a useful technique because allows a direct correlation between anatomic and functional information [5]. If recurrent parathyroid cancer is suspected, neck and chest CT or MRI scans should be performed [6,20,21].…”

Section: Localizing Examination Of Parathyroid Cancermentioning

confidence: 99%

“…Fine needle aspiration biopsy (FNA) is not reliable because of common false-negative results, and if it is performed, it should be used with caution due to the risk of rupturing the capsule and consequent seeding of tumour cells (parathyromatosis) [6,13,16]. However, FNA may occasionally be utilised in the setting of suspected metastatic disease or in cases of recurrence, with the purpose of confirming the diagnosis prior to more radical surgical interventions [10].…”

Section: Histopathological Examinationmentioning

confidence: 99%

“…They contain: increased mitotic activity, thick fibrous bands, trabecular growth pattern, and capsular and blood vessels invasion (present in over 60% of cases) [15,18,45]. Unfortunately, none of these criteria are specific only for parathyroid carcinoma; they can also be observed in benign parathyroid lesions and are not always present in cases of malignancy [5,6,18]. In particular, oxyphil adenoma can mimic PC because both are rich in oxyphil cells, contrary to typical adenoma, which is formed from chief cells [6].…”

Section: Histopathological Examinationmentioning

confidence: 99%

“…It is a rare endocrine malignancy [3][4][5][6], which originates in the parenchymatous cells of the parathyroid glands [1]. Most parathyroid cancers secrete PTH and cause hypercalcaemia in the course of primary hyperparathyroidism [7,8].…”

Section: Introductionmentioning

confidence: 99%

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Pierwotna nadczynność przytarczyc w przebiegu raka przytarczyc — wyzwanie diagnostyczne i terapeutyczne

Dabrowska

Tarach

Zwolak

2015

Endokrynologia Polska

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Parathyroid carcinoma (PC) is a rare endocrine malignancy and the cause of primary hyperparathyroidism. It is usually associated with a high rate of local and distant recurrence. Laboratory findings and clinical symptoms may be similar to those in parathyroid adenoma. The histological features of PC may also be non-specific and the affected gland is often indistinguishable from a benign lesion. The proper diagnosis is commonly made months to years later when the disease recurs or metastases are present. Therefore, parathyroid carcinoma still remains a diagnostic and management challenge for many physicians. However, there are some features that, in combination, may help in diagnosis. Surgery still remains the only curative treatment, even in metastatic disease. In advanced, non-operable subjects, managing hypercalcaemia and controlling a tumour are the main goals. Morbidity is caused by hypercalcaemia rather than metastases. A multidisciplinary approach with experienced endocrinologists, pathologists, radiologists, nuclear medicine doctors, oncologists, and surgeons is needed to optimize patient outcome. StreszczenieRak przytarczyc (PC) jest rzadkim nowotworem złośliwym układu wewnątrzwydzielniczego, a także rzadką przyczyną pierwotnej nadczynności przytarczyc. Zazwyczaj wiąże się z wysokim odsetkiem miejscowych i odległych przerzutów. Wyniki badań laboratoryjnych i objawy kliniczne mogą przypominać te spotykane w przebiegu gruczolaków przytarczyc. Równie niespecyficzny jest obraz histopatologiczny raka przytarczyc, co powoduje trudności w diagnostyce różnicowej ze zmianami łagodnymi, będącymi gruczolakami. Właściwe rozpoznanie często jest stawiane z kilkumiesięcznym lub kilkuletnim opóźnieniem, w oparciu o nawrót choroby lub pojawiające się przerzuty. Mając na uwadze ten fakt, rak przytarczyc ciągle pozostaje wyzwaniem diagnostycznym i terapeutycznym dla wielu specjalistów. Jakkolwiek, wyróżnia się jednak pewne objawy, których obecność może pomóc w postawieniu właściwej diagnozy. Leczenie chirurgiczne pozostaje nadal jedyną skuteczną opcją terapeutyczną, nawet w sytuacji pojawienia się zmian przerzutowych. W zaawansowanych, nieoperacyjnych przypadkach głównym celem leczenia pozostaje obniżanie stężenia wapnia we krwi i kontrola wielkości guza. Śmiertelność związana z rakiem przytarczyc wynika raczej z hiperkalcemii, niż obecności przerzutów. W celu poprawy wyników leczenia, niezbędne jest podejście wielodyscyplinarne oraz współdziałanie wielu doświadczonych specjalistów: endokrynologów, patologów, radiologów, medyków nuklearnych, onkologów i chirurgów.

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Section: Epidemiology Of Parathyroid Carcinomamentioning

confidence: 99%

Section: Localizing Examination Of Parathyroid Cancermentioning

confidence: 99%

Section: Histopathological Examinationmentioning

confidence: 99%

Section: Histopathological Examinationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Pierwotna nadczynność przytarczyc w przebiegu raka przytarczyc — wyzwanie diagnostyczne i terapeutyczne

Dabrowska

Tarach

Zwolak

2015

Endokrynologia Polska

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Oncocytic Lesions of the Thyroid, Kidney, Salivary Glands, Adrenal Cortex, and Parathyroid Glands

2014

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Oncocytic cell represents a special phenotype of neoplastic cells reflecting a unique biologic process characterized by the huge proliferation of morphologically abnormal mitochondria in the cytoplasm of neoplastic cells. This phenotype is driven by quite specific molecular mechanisms that interfere with mitochondrial function and metabolism. The oncocytic phenotype is more common in tumors arising in tissues presenting low proliferative rate, such as thyroid, kidney, salivary glands, adrenal cortex, and parathyroid glands, and it is superimposed on the genotypic and conventional histologic features of the tumors. In this short review, we address the similarity of the molecular alterations and of the biological features of the neoplastic cells in the oncocytic tumors of the different organs. We also discuss the differential diagnosis of benign and malignant oncocytic tumors as well as the prognosis of the malignant ones. We conclude that this rather unique phenotype, which is observed in tumors from different organs, indicates common metabolic alterations that may represent a useful target for therapeutic purposes.

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Subcutaneous implantation of metastatic carcinoma: An unpredicted event following endoscopic parathroidectomy for adenoma

Bhattacharya

Chaturvedi

Abrari

et al. 2015

South Asian J Cancer

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Parathyroid carcinoma and oxyphil parathyroid adenoma: an uncommon case of misinterpretation in clinical practice

Cited by 3 publications

References 39 publications

Pierwotna nadczynność przytarczyc w przebiegu raka przytarczyc — wyzwanie diagnostyczne i terapeutyczne

Pierwotna nadczynność przytarczyc w przebiegu raka przytarczyc — wyzwanie diagnostyczne i terapeutyczne

Oncocytic Lesions of the Thyroid, Kidney, Salivary Glands, Adrenal Cortex, and Parathyroid Glands

Subcutaneous implantation of metastatic carcinoma: An unpredicted event following endoscopic parathroidectomy for adenoma

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