Parathyroid cancer: biology and management

Parathyroid carcinoma: a 16-year experience in a single institution

“…In our series, one patient had a history of end-stage renal disease, and the others had no above-mentioned history. On a physical examination, whereas patients with parathyroid adenoma rarely presents with neck masses, up to 50% of patients with parathyroid carcinoma present with palpable neck masses because of locally advanced diseases [15].…”

“…Renal involvement, including nephrolithiasis, nephrocalcinosis, and renal insufficiency presents in 30-84% of patients [16], and skeletal involvement, including osteofibrosis, osteoporosis, pathologic fractures, and bone pain occurs in more than 40% of patients [17]. Concomitant renal and skeleton involvement has been observed in up to 50% of patients with parathyroid carcinoma, but it is rare in patients with parathyroid adenoma [15]. Other symptoms of parathyroid carcinoma include fatigue, weakness, weight loss, anorexia, polyuria, and polydipsia; but those can be caused by other problems.…”

Parathyroid carcinoma: A 22‐year experience

“…With the exception of the Mayo Clinic report, 11 many previous case series are small or based on data from multiple institutions over variable time periods. 7,10,12 Over time, diagnostic tools have evolved significantly, rendering it difficult to compare data regarding disease stage and clinical outcomes, such as disease-related morbidity and mortality. In this article, we report our institution's experience during the past 22 years; during this interval, diagnostic imaging and biochemical analysis technology have been relatively constant and comparable.…”

Non-functional parathyroid carcinoma: a case report and review of the literature

“…68 The overall prognosis of the nonfunctioning parathyroid carcinoma is not favorable. 17 Death in patients with nonfunctional parathyroid tumors is primarily due to the volume of regional disease and metastases.…”