Parathormone-Like Effect of Magnesium Replenishment in Steatorrhea

Muldowney, Francis P.; McKenna, T. J.; Kyle, Laurence H.; Freaney, R.; Swan, M.

doi:10.1056/nejm197001082820203

Cited by 98 publications

(29 citation statements)

References 29 publications

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“…One main reason is the skeletal resistance to the calcemic action of parathyrin. In patients with hypomagnesemia, several authors could not restore the lowered values of serum calcium by administration of parathyroid extract (175)(176)(177). However, administration of magnesium alone normalized the responsiveness to parathyroid extract in these patients.…”

Section: Hypomagnesemiamentioning

confidence: 99%

Magnesium Metabolism: A Review

Ebel¹,

Günther²

1980

CCLM

156

122

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Summary: The main literature concerning the physiology and biochemistry as well as the pathophysiology and pathobiochemistry of magnesium is reviewed, including:Distribution and physico-chemical state of magnesium in the extracellular and intracellular fluid as well as in the subcellular organelles (membranes, mitochondria, microsomes, ribosomes).Intestinal resorption, transport across membranes and excretion by the kidney.Hormonal regulation of magnesium distribution and its clinical disturbances.Biochemical mechanism and the clinical effects of hypo-and hypermagnesemia. Magnesium-Stoffwechsel: Eine ÜbersichtZusammenfassung: Die wichtigsten Arbeiten über die Physiologie und Biochemie sowie Pathophysiologie und Pathobiochemie des Magnesiums werden dargestellt.Die Darstellung bezieht sich im wesentlichen auf: Die Verteilung und den physikalisch-chemischen Zustand des Mg in der extrazellulären und intrazellulären Flüssigkeit und in den Zellorgänellen (Membranen, Mitochondrien, Mikrosomen, Ribosomen). Die Resorption im Darm, Transport durch Membranen und die Ausscheidung durch die Niere.Die hormonale Regulation der Mg-Verteilung und ihre klinischen Störungen. Biochemische Mechanismen und klinische Erscheinungen bei Hypo-und Hypermagnesiämie.

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Section: Hypomagnesemiamentioning

confidence: 99%

Magnesium Metabolism: A Review

Ebel¹,

Günther²

1980

CCLM

156

122

View full text Add to dashboard Cite

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“…Previous reports have shown that complete or partial resistance to the skeletal action of PTH may occur during magnesium depletion in various species, including the rat (1), human (11)(12)(13)(14) and dog (8). Others have found normal action of PTH and have concluded that the hypocalcemia could not be due to abnormal skeletal response to the hormone (2,7,9).…”

Section: Studies On Mechanisms Of Hypocalcemia Of Magnesium Depletionmentioning

confidence: 99%

“…Hypocalcemia has been reported to be associated with magnesium depletion in a number of species, including rats fed a low calcium diet (1, 2), sheep (3), pigs (4), calves (5, 6), dogs (7,8), monkeys (9), and man (10)(11)(12)(13)(14) In the present study, a model of experimental magnesium depletion in the chick is described, and various factors which might be involved in the development of hypocalcemia were evaluated. METHODS White leghorn cockerels obtained 1 day after hatching (through courtesy of H & N Hatchery, Inc., Riverside, Calif.) were housed in electric brooders.…”

Section: Introductionmentioning

confidence: 99%

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Studies on Mechanisms of Hypocalcemia of Magnesium Depletion

Reddy¹,

Coburn²,

Hartenbower³

et al. 1973

J. Clin. Invest.

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A B S T R A C T Studies were carried out to evaluate the mechanism of hypocalcemia in magnesium depletion. Day old chicks fed a magnesium deficient diet developed marked hypocalcemia, with a direct relation between serum calcium (y) and magnesium (x): y = 2.68 x + 4.24, r = 0.84 (both in mg/100 ml). Injections of parathyroid extract that increased serum calcium 2-3 mg/100 ml in normals had no effect in Mg-depleted birds. Very large dietary supplements of calcium or vitamin D3 increased mean serum calcium only from 5.3 to 7.7 and 7.8 mg/100 ml, respectively, while a normal magnesium diet for 3 days increased calcium from 5.3 to 9.9 mg/100 ml despite absence of dietary calcium. Intestinal calcium transport, studied in vitro, and the calcium concentration of the carcass was significantly increased in magnesium-depleted chicks, making it unlikely that reduced intestinal absorption of calcium caused the hypocalcemia. In magnesium-deficient chicks, the bone content of magnesium was decreased by 74%, the calcium content was unchanged, and the cortical thickness of bone was markedly increased. After 3 days of magnesium-repletion, cortical thickness was reduced with increased endosteal resorption. There INTRODUCTIONHypocalcemia has been reported to be associated with magnesium depletion in a number of species, including rats fed a low calcium diet (1, 2), sheep (3), pigs (4), calves (5, 6), dogs (7,8), monkeys (9), and man (10)(11)(12)(13)(14) In the present study, a model of experimental magnesium depletion in the chick is described, and various factors which might be involved in the development of hypocalcemia were evaluated. METHODS White leghorn cockerels obtained 1 day after hatching (through courtesy of H & N Hatchery, Inc., Riverside, Calif.) were housed in electric brooders. Chicks were chosen as experimental models because their diet can be controlled immediately after hatching, permitting the rapid development of magnesium depletion. In addition, chickens are known to be sensitive to parathyroid extract (15), thus providing a suitable model to evaluate responsiveness to the hormone. Furthermore, considerable information is available concerning calcium homeostasis in this species.They received a synthetic diet, modified from that of Fox and Briggs (16), and distilled water ad libitum. The diet, as originally described, contained 0.060% magnesium, an amount considered the optimal quantity needed by growing chicks (16,17). With deletion of supplemental magnesium and calcium salts, the basic diet was found by analysis to contain 0.004% magnesium and 0.005% calcium. In preparation of certain diets discussed below, magnesium sulfate was added providing 0.010, 0.020, or 0.060% magnesium.Unless noted otherwise, the diets were supplemented to contain 1.2% calcium, an amount higher than the 0.7-0.8% usually provided, 0.8% phosphorus, and 80 IU of vitamin D3 (cholecalciferol) /100 g.For purposes of establishing the appropriate dietary magnesium for studying magnesium depletion in the fowl, preliminary experiments were ...

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“…Received for publication 30 August 1971 and in revised form 8 November 1971. including familial hypomagnesemia (1-3), alcoholism (4), chronic steatorrhea (5,6), and magnesium deprivation in human volunteers (7,8). In magnesiumdepleted normal volunteers and individuals with familial hypomagnesemia, the hypocalcemia is often associated with mild elevations in serum phosphate.…”

Section: -676-05)mentioning

confidence: 99%