Parasitological and biochemical studies on cutaneous leishmaniasis in Shara’b District, Taiz, Yemen

Asmaa, Qhtan; AL-Shamerii, Salwa; Al-Tag, Mohammed; AL-Shamerii, Adam; Li, Yiping; Osman, Bashir H.

doi:10.1186/s12941-017-0224-y

Cited by 23 publications

(37 citation statements)

References 44 publications

(51 reference statements)

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“…Herein, treatment with Ag-NPs green synthesized with M. oleifera leaf extract may protect cells from damage, demise and dysfunction that caused by cutaneous leishmaniosis-induced oxidative stress. The present results obtained for antioxidant enzyme activities are in accordance to several authors who found significant reduction in GPx in skin of infected mice and attributed these changes to the number of deleterious effects due to the accumulation of superoxide radicals and hydrogen peroxide [ 43 ].…”

Section: Discussionsupporting

confidence: 92%

Clinical Efficacy Associated with Enhanced Antioxidant Enzyme Activities of Silver Nanoparticles Biosynthesized Using Moringa oleifera Leaf Extract, Against Cutaneous Leishmaniasis in a Murine Model of Leishmania major

El‐Khadragy

Al-Olayan

Metwally

et al. 2018

IJERPH

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Leishmaniasis is one of the most significant vector-borne syndromes of individuals. This parasitic infection can be affected by many species of Leishmania, most of which are zoonotic. Natural products have made and are continuing to make important contributions to the search for new antileishmanial agents. The use of plants in the production assembly of silver nanoparticles has drawn attention because of its rapid, eco-friendly, non-pathogenic, economical protocol and provides a single step technique for the biosynthetic process. Hence, we aimed to biosynthesize silver nanoparticles (Ag-NPs) using Moringa oleifera leaf extract and investigated the antileishmanial activity of these nanoparticles in a murine model of Leishmania major infection. A total of 50 mice were used and divided into five groups—healthy control, infected, infected mice treated with pentostam, infected mice treated with Ag-NPs and infected mice pretreated with Ag-NPs. In the present study, the leaf extract of the plant species Moringa oleifera was found to be a good source for the synthesis of silver nanoparticles, their formation being confirmed by color change and stability in solution. In the present murine model of Leishmania major infection, we found that oral treatment with silver nanoparticles biosynthesized using Moringa oleifera extract resulted in a significant reduction in the average size of leishmaniasis cutaneous lesions compared with untreated mice. Furthermore, the clinical efficacy of Moringa oleifera extract was associated with enhanced antioxidant enzyme activities. In conclusion, treatment with silver nanoparticles biosynthesized using Moringa oleifera extract has higher and faster clinical efficacy than standard pentavalent antimonial treatment, probably by boosting the endogenous antioxidant activity.

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Section: Discussionsupporting

confidence: 92%

Clinical Efficacy Associated with Enhanced Antioxidant Enzyme Activities of Silver Nanoparticles Biosynthesized Using Moringa oleifera Leaf Extract, Against Cutaneous Leishmaniasis in a Murine Model of Leishmania major

El‐Khadragy

Al-Olayan

Metwally

et al. 2018

IJERPH

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“…Cases were collected at Maarshorin and Khan-shikhon Center in Idlep-Syria. Diagnosis was confirmed clinically, as well as by laboratory demonstration of the parasite in the lesions by direct smears using microscopic examination as mentioned early by [10], briefly, tissue scrapings performed with staining the specimen with by Giemsa stain. The lesions cleaned and any eschars or exudates was removed.…”

Section: Diagnosis Of CLmentioning

confidence: 95%

Renal function tests in patients with Cutaneous Leishmania after treatment with Glucantime

Hasani¹,

Kotayni²,

kabba³

2020

IJEAS

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Cutaneous leishmaniasis (CL) has historically been present in Syria, mainly in the western part of the country. The present study was conducted to evaluate kidney function parameters in patients infected with CL in Idlep-Syria. This is controlled study contain infected (60) and control (30) groups. The prevalence and distribution of infection were studied, kidney function testes were determined by colorimetric methods, (Biosystem ®). Among 100 of a total cases studied, the percent of infected cases are 60 % and not infected are 40%. The distribution of lesions on various parts of body in patients shows the highest percent of infection was in face (50%). There were highly significant increase in urea, uric acid and creatinine in infected group (p <0.0001) as compared to control one. In the war in Syria, the prevalence of infection was increased and had side effect on kidney parameter in infected patients treated with Glucantime.

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“…Taiz governorate (44.01° E, 13.34° N) is located in the southwestern part of Yemen, 280 km from Sana'a, the capital. Shar'ab district was selected because a recent study con rmed that it is endemic for CL [10]. The ve abovementioned areas of Shar'ab district were selected because the same study showed that these areas had the highest prevalence of CL infection [10].…”

Section: Study Areamentioning

confidence: 99%

“…In Yemen, although the rst report of CL was documented in 1933, and the disease represented about 5% of skin diseases [5,6], little is known about the epidemiological features and temporospatial evolution of the disease. Previous studies have revealed that CL is mainly endemic in the northwestern, southwestern, and central highland areas of the country [7][8][9][10]. According to the World Health Organisation (WHO), 4,763 CL cases were reported in Yemen in 2018 [11].…”

Section: Introductionmentioning

confidence: 99%

“…The main causative species is L. tropica, with Phlebotomus arabicus implicated as the potential vector [12] and rock hyrax as the reservoir host [7]. Hajjah and Al-Bayda governorates in the northwestern and central highlands, respectively, have been found to have the highest number of reported cases [6,7] while Lahj and Taiz governorates have been reported to have the highest number of reported cases in the southwestern region [8][9][10].…”

Section: Introductionmentioning

confidence: 99%

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Knowledge and Attitude of the Local Community Towards Cutaneous Leishmaniasis in Rural Endemic Areas in Southwestern Yemen

Alhrazi¹,

Haouas²,

Al-Mekhlafi³

2020

Preprint

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BackgroundCutaneous leishmaniasis (CL), a historically neglected tropical disease, represents a significant public health problem in many endemic countries including Yemen. The ongoing armed conflict that started in March 2015 has had a negative impact on the entire healthcare system including infectious disease control programmes. Therefore, this cross-sectional study aimed to assess the knowledge and attitude towards CL among endemic communities in southwestern Yemen. MethodsFive hundred households in five areas of Shar’ab district of Taiz governorate were randomly selected to participate in a quantitative survey. A pretested structured questionnaire was used to collect information on the participants’ sociodemographic background and their knowledge and attitude towards CL and the sand fly vector.ResultsThe analysis was conducted on a final sample of 466 individuals. Although the participants were aware of CL, about three quarters (77.7%) of them had poor overall knowledge about disease transmission, clinical presentation, treatment and prevention. Interestingly, about half of the participants (49.1%) were able to differentiate sand flies from other flies and mosquitoes; however, only 14.8% of the participants knew about the role of the phlebotomine sand fly in the transmission of CL. Similarly, the participants had poor overall knowledge about sand fly breeding sites, biting time and control measures. Although 44% of the participants considered CL to be more dangerous than malaria, only 36.6% believed that CL can be prevented and 76.4% had a negative attitude towards the disease. Univariate and multivariate analyses showed that age and gender were the significant determinants of knowledge about CL and the sand fly vector among the studied population.Conclusion A poor level of knowledge about the different epidemiological aspects of CL was found among the rural population in Taiz. This factor, together with the major collapse of the healthcare infrastructure and the paralysis of health authorities since the beginning of the ongoing civil war in Yemen, may be contributing to the continued endemicity of CL in the area. Hence, health education on CL transmission and prevention should be provided to the targeted communities.

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Parasitological and biochemical studies on cutaneous leishmaniasis in Shara’b District, Taiz, Yemen

Cited by 23 publications

References 44 publications

Clinical Efficacy Associated with Enhanced Antioxidant Enzyme Activities of Silver Nanoparticles Biosynthesized Using Moringa oleifera Leaf Extract, Against Cutaneous Leishmaniasis in a Murine Model of Leishmania major

Clinical Efficacy Associated with Enhanced Antioxidant Enzyme Activities of Silver Nanoparticles Biosynthesized Using Moringa oleifera Leaf Extract, Against Cutaneous Leishmaniasis in a Murine Model of Leishmania major

Renal function tests in patients with Cutaneous Leishmania after treatment with Glucantime

Knowledge and Attitude of the Local Community Towards Cutaneous Leishmaniasis in Rural Endemic Areas in Southwestern Yemen

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