The trend toward high power density engines has led to new implementation of more intelligent thermal management systems. Advanced thermal management systems for internal combustion engines can help in reducing the fuel consumption, pollutant emissions, warm up time, noise level as well as improving comfort and engine durability. In this study, the effect of advanced thermal management system on heavy duty (HD) diesel engine was investigated using FTP-75 driving cycle. Firstly, the cooling system model was validated with experimental data, and then replaced with an advanced thermal management system with PID feedback control using a 1-D simulation model. The simulation results showed a reduction in the time of cold start by 50%, reduction in power consumption of the cooling system by 13%, decrease fuel consumption (4:11) % and decreasing the total frictional torque by 10%. This study investigates how the thermal management system enhances the overall HD diesel engine efficiency.