PARASITES AND CANCER: SARCOMA IN DOGS ASSOCIATED WITH SPIROCERCA <i>LUPI</i>*

Bailey, W. S.

doi:10.1111/j.1749-6632.1963.tb13429.x

Cited by 78 publications

(56 citation statements)

References 13 publications

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“…There does however seem to be a breed predilection. Hounds and large breed dogs have a higher incidence of S. lupi than other breeds ( [Bailey, 1963] and [Lobetti, 2000]). A study conducted in Greece showed a disease prevalence of 10% in 260 privately owned dogs (Mylonakis et al, 2001).…”

Section: Distributionmentioning

confidence: 96%

“…After their final moult, approximately 3 months post-infection, they migrate as immature adults, from the caudal thoracic aorta to the caudal oesophagus where they are found from days 93-227. Here they live in nodules in the submucosa and adventitia of the oesophagus (Bailey, 1963). Even larvae implanted into the host sites other than the gastrointestinal tract are eventually found in the aorta or oesophagus (Bailey, 1972).…”

Section: Life-cyclementioning

confidence: 99%

“…Mature oesophageal nodules containing adult worms are present by 3-9 months ( [Bailey, 1963] and [Sen and Anataraman, 1971]). The adult is a large spiralled pink worm with males up to 54 mm and females up to 80 mm in length (Soulsby, 1982).…”

Section: Life-cyclementioning

confidence: 99%

“…Metaplastic ossification of the aorta, to the extent of bone marrow formation, has been reported (Kumar et al, 1981b). Aortic lesions are the most common lesion associated with spirocercosis and are considered pathognomonic ( [Bailey, 1963] and [Ramachandran et al, 1984]). Spondylitis of the thoracic vertebrae is an almost invariable finding in spirocercosis but the pathogenesis has not been elucidated ( [Bailey, 1963] and [Ramachandran et al, 1984]).…”

Section: Pathogenesis and Pathologymentioning

confidence: 99%

“…Aortic lesions are the most common lesion associated with spirocercosis and are considered pathognomonic ( [Bailey, 1963] and [Ramachandran et al, 1984]). Spondylitis of the thoracic vertebrae is an almost invariable finding in spirocercosis but the pathogenesis has not been elucidated ( [Bailey, 1963] and [Ramachandran et al, 1984]). As only the vertebrae directly adjacent to the descending aorta seem to be involved, aberrant migration or severe peri-aortic inflammation secondary to aortic migration are possible causes.…”

Section: Pathogenesis and Pathologymentioning

confidence: 99%

See 4 more Smart Citations

Spirocerca lupi infection in the dog: A review

Merwe

Kirberger

Clift

et al. 2008

The Veterinary Journal

160

191

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Spirocercosis is a disease occurring predominantly in Canidae, caused by the nematode Spirocerca lupi. Typical clinical signs are regurgitation, vomiting and dyspnoea. The lifecycle involves an intermediate (coprophagous beetle) and a variety of paratenic hosts. Larvae follow a specific migratory route, penetrating the gastric mucosa of the host, migrating along arteries, maturing in the thoracic aorta before eventually moving to the caudal oesophagus. Here the worm lives in nodules and passes larvated eggs which can be detected using zinc sulphate faecal flotation. Histologically, the mature oesophageal nodule is composed mostly of actively dividing fibroblasts.Spirocerca lupi-associated oesophageal sarcomas may occur and damage to the aorta results in aneurysms. A pathognomonic lesion for spirocercosis is spondylitis of the thoracic vertebrae. Primary radiological lesions include an oesophageal mass, usually in the terminal oesophagus, spondylitis, and undulation of the aortic border. Contrast radiography and computed tomography are helpful additional emerging modalities. Oesophageal endoscopy has a greater diagnostic sensitivity than radiography. Endoscopic biopsies are not sensitive for detecting neoplastic transformation. Doramectin is the current drug of choice, effectively killing adult worms and decreasing egg shedding. Early diagnosis of infection is still a challenge and to date no ideal regimen for prophylaxis has been published.

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Section: Distributionmentioning

confidence: 96%

Section: Life-cyclementioning

confidence: 99%

Section: Life-cyclementioning

confidence: 99%