Parasite-based interventions in systemic lupus erythematosus (SLE): A systematic review

Jafari, Amirhossein Azari; Keikha, Mojtaba; Mirmoeeni, Seyyedmohammadsadeq; Rahimi, Mohammad Taghi; Jafari, Reza

doi:10.1016/j.autrev.2021.102896

Cited by 7 publications

(5 citation statements)

References 64 publications

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“…The high prevalence, detrimental effects, and increasing drug resistance of helminths [ 12 , 13 ] have led to much research on developing vaccines [ 14 , 15 , 16 , 17 , 18 ]; however, despite promising results, there is still much to be done to achieve final success. Fully eradicating helminth infections may even in some aspects be controversial, since they may mitigate autoimmune diseases [ 19 , 20 , 21 ] and allergies [ 22 , 23 ] by dampening Th 1 and inducing Th 2 host immune responses [ 24 , 25 ]. The resulting main effects of this response typically are the presence of alternatively activated macrophages, tissue repair, eosinophilia, and the production of IgE [ 26 , 27 ].…”

Section: Helminthsmentioning

confidence: 99%

The Role of the Intestinal Epithelium in the “Weep and Sweep” Response during Gastro—Intestinal Helminth Infections

Bąska

Norbury

2022

Animals

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Helminths are metazoan parasites infecting around 1.5 billion people all over the world. During coevolution with hosts, worms have developed numerous ways to trick and evade the host immune response, and because of their size, they cannot be internalized and killed by immune cells in the same way as bacteria or viruses. During infection, a substantial Th2 component to the immune response is evoked which helps restrain Th1-mediated tissue damage. Although an enhanced Th2 response is often not enough to kill the parasite and terminate an infection in itself, when tightly coordinated with the nervous, endocrine, and motor systems it can dislodge parasites from tissues and expel them from the gut. A significant role in this “weep and seep” response is attributed to intestinal epithelial cells (IEC). This review highlights the role of various IEC lineages (enterocytes, tuft cells, Paneth cells, microfold cells, goblet cells, and intestine stem cells) during the course of helminth infections and summarizes their roles in regulating gut architecture and permeability, and muscle contractions and interactions with the immune and nervous system.

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Section: Helminthsmentioning

confidence: 99%

The Role of the Intestinal Epithelium in the “Weep and Sweep” Response during Gastro—Intestinal Helminth Infections

Bąska

Norbury

2022

Animals

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“…Our results also agree with those of a previous research which showed that patients with autoimmune disease, such as SLE, are more likely to be infected with toxoplasmosis. This explains the high prevalence of T. gondii among SLE patients [20].Other reports demonstrated that T. gondii seropositivity rate in SLE patients was 60%. Likewise, rheumatoid arthritis and SLE patients tested positive for toxoplasmosis-specific antibodies [21,22].…”

Section: Discussionmentioning

confidence: 86%

effects of toxoplasmosis infection on the levels of IL-18 and anti-ds-DNA antibodies in SLE patients

Fadhel

Zghair

2022

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The present study was set to demonstrate the prevalence of toxoplasmosis infection and its effects on patients with systemic lupus erythematosus (SLE) through determining their serum levels of anti-dsDNA and IL-18 antibodies. For this purpose, the sera from 132 SLE and/or toxoplasmosis patients and 30 healthy women, were collected. The study sample was divided into four groups of SLE, toxoplasmosis, SLE coinfected with toxoplasmosis, and healthy control. Anti-Toxoplasma IgG antibodies were examined for all the samples using ELISA kit. The results showed a high mean level of anti-Toxoplasma IgG among SLE patients coinfected with toxoplasmosis (104.8792±12.31585pg/ml) in comparison to that in toxoplasmosis patients (91.1705±12.57746pg/ml). However, the mean value of anti-dsDNA antibodies showed significant (P≤0.01) elevation in SLE patients and SLE patients coinfected with toxoplasmosis (71.2134±9.22131pg/ml and 72.3699±9.67917 pg/ml, respectively), compared to those infected with toxoplasmosis only and healthy control. Furthermore, the IL-18 mean value in the sera of the studied patients showed significant (P≤0.01) elevation (418.4000±43.18072pg/ml) in SLE patients with toxoplasmosis in comparison to SLE patients (354.4400±35.29257pg/ml). The present investigation suggests that the levels of anti-Toxoplasma IgG antibodies seem to increase in patients with SLE.

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“…Intriguingly, the pathways “toxo–plasmosis” and “leishmaniasis”, which are involved in similar intracellular parasitic infections affecting internal organs, including the liver, were enriched. The autoimmune disease terms “rheumatoid arthritis” and “inflammatory bowel disease (IBD)” were unexpectedly enriched KEGG pathways, suggesting underlying cross-talk of immune responses between intracellular parasitic infections and autoimmunity due to the imbalance of pro-/anti-inflammatory responses [ 39 , 40 ].…”

Section: Resultsmentioning

confidence: 99%

Genome-wide liver transcriptomic profiling of a malaria mouse model reveals disturbed immune and metabolic responses

Zhao

et al. 2023

Parasites Vectors

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Background The liver is responsible for a range of functions in vertebrates, such as metabolism and immunity. In malaria, the liver plays a crucial role in the interaction between the parasite and host. Although malarial hepatitis is a common clinical complication of severe malaria, other malaria-related liver changes have been overlooked during the blood stage of the parasite life-cycle, in contrast to the many studies that have focused on parasite invasion of and replication in the liver during the hepatic stage of the parasite. Methods A rodent model of malaria was established using Plasmodium yoelii strain 17XL, a lethal strain of rodent malaria, for liver transcriptomic profiling. Results Differentially expressed messenger RNAs were associated with innate and adaptive immune responses, while differentially expressed long noncoding RNAs were enriched in the regulation of metabolism-related pathways, such as lipid metabolism. The coexpression network showed that host genes were related to cellular transport and tissue remodeling. Hub gene analysis of P. yoelii indicated that ubiquitination genes that were coexpressed with the host were evolutionarily conserved. Conclusions Our analysis yielded evidence of activated immune responses, aberrant metabolic processes and tissue remodeling changes in the livers of mice with malaria during the blood stage of the parasite, which provided a systematic outline of liver responses during Plasmodium infection. Graphical Abstract

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Parasite-based interventions in systemic lupus erythematosus (SLE): A systematic review

Cited by 7 publications

References 64 publications

The Role of the Intestinal Epithelium in the “Weep and Sweep” Response during Gastro—Intestinal Helminth Infections

The Role of the Intestinal Epithelium in the “Weep and Sweep” Response during Gastro—Intestinal Helminth Infections

effects of toxoplasmosis infection on the levels of IL-18 and anti-ds-DNA antibodies in SLE patients

Genome-wide liver transcriptomic profiling of a malaria mouse model reveals disturbed immune and metabolic responses

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