Parasagittal zonal pattern of olivo-nodular projections in rabbit cerebellum

Katayama, Seiji; Nisimaru, Naoko

doi:10.1016/0168-0102(88)90027-2

Cited by 79 publications

(34 citation statements)

References 21 publications

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“…Cerebellar zones containing rVA cells receive input from the caudal dorsal cap, whereas r45 c cells receive input from the rostral dorsal cap and ventrolateral outgrowth. 2,16,23 Nonetheless, in the present study, we found no appreciable differences in the location of retrograde labeling in the IO following injections at locations containing rVA vs r45 c cells. Likewise, we found no obvious differences in the locations of retrogradely labeled cells following injections in areas of the translation zone at locations containing different response types.…”

Section: Discussioncontrasting

confidence: 47%

“…2,16,23 Barmack et al 3,4,5 have shown that many neurons in this zone and the beta subnucleus respond to static head tilt, thus demonstrating an input originating in the otolith organs. Although not self-translation per se, the medial zone of the nodulus/uvula and the beta subnucleus in rabbits receive inputs related to linear acceleration during self-motion, as does the medial VbC in pigeons.…”

Section: Comparative Considerationsmentioning

confidence: 99%

“…Given these findings, it is not surprising that, in rabbits, the ventral uvula, nodulus and flocculus receive input from the same areas of the IO, namely the dorsal cap and ventrolateral outgrowth. 2,16,23 In fact, Takeda and Maekawa 21,22 have shown that individual IO neurons in rabbits project to the uvula/ nodulus and the flocculus. From the present study we conclude that the dorsomedial mc of pigeons is functionally equivalent to the dorsal cap and ventrolateral outgrowth of mammals, because these structures provide input to rotation cells.…”

Section: Comparative Considerationsmentioning

confidence: 99%

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Topographical organization of inferior olive cells projecting to translation and rotation zones in the vestibulocerebellum of pigeons

et al. 1998

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Abstract--Previous electrophysiological studies in pigeons have shown that the vestibulocerebellum can be divided into two parasagittal zones based on responses to optic flow stimuli. The medial zone responds best to optic flow resulting from self-translation, whereas the lateral zone responds best to optic flow resulting from self-rotation. This information arrives from the retina via a projection from the accessory optic system to the medial column of the inferior olive. In this study we investigated inferior olive projections to translational and rotational zones of the vestibulocerebellum using the retrograde tracer cholera toxin subunit B. Extracellular recordings of Purkinje cell activity (complex spikes) in response to large-field visual stimuli were used to identify the injection sites. We found a distinct segregation of inferior olive cells projecting to translational and rotational zones of the vestibulocerebellum. Translation zone injections resulted in retrogradely labeled cells in the ventrolateral area of the medial column, whereas rotation zone injections resulted in retrogradely labeled cells in the dorsomedial region of the medial column.Motion of any object through space, including self-motion of organisms, can be described with reference to translation and rotation in three-dimensional space. Our results show that, in pigeons, the brainstem visual systems responsible for detecting optic flow are segregated into channels responsible for the analysis of translational and rotational optic flow in the inferior olive, which is only two synapses from the retina. 1998 IBRO. Published by Elsevier Science Ltd.

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Section: Discussioncontrasting

confidence: 47%

Section: Comparative Considerationsmentioning

confidence: 99%

Section: Comparative Considerationsmentioning

confidence: 99%

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Topographical organization of inferior olive cells projecting to translation and rotation zones in the vestibulocerebellum of pigeons

et al. 1998

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“…In rabbits, olivocerebellar fibers originating in specific olivary nuclei terminate in five distinct zones in lobule X (Katayama and Nisimaru, 1988;Tan et al, 1995b), although there is evidence that this organization may vary between different species (Voogd and Ruigrok, 1997). Lobule X, along with the flocculus, is part of the vestibulocerebellum and receives mossy fiber input from vestibular nuclei.…”

Section: Hsp25 Expression In the Nzmentioning

confidence: 99%

Constitutive expression of the 25-kDa heat shock protein Hsp25 reveals novel parasagittal bands of Purkinje cells in the adult mouse cerebellar cortex

et al. 2000

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“…It is notable that PKC expression changes were absent in the adjacent ventral paraflocculus, which contains the part of zone FE that receives input from the rostral dorsal cap. Anatomical evidence from the rat (Bernard, 1987) and rabbit (Balaban and Henry, 1988;Katayama and Nisimaru, 1988;Tan et al, 1995) suggests that the intermediate part of the nodulus receives climbing fiber input predominantly from the dorsal cap and ventrolateral outgrowth. Dorsal cap neurons are activated by the retinal slip stimulation (Leonard et al, 1988), implying that early changes in flocculonodular-lobe PKC expression may represent local intracellular responses to changes in climbing fiber activity that reflect spontaneous nystagmus during the initial hours after UL.…”

Section: Flocculusmentioning

confidence: 99%

Transient Changes in Flocculonodular Lobe Protein Kinase C Expression during Vestibular Compensation

Goto¹,

Romero²,

Balaban

1997

J. Neurosci.

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Protein kinase C (PKC) is a family of intracellular signal transduction enzymes, comprising isoforms that vary in sensitivity to calcium, arachidonic acid, and diacylglycerol. PKC isoforms ␣, ␥, and ␦ are expressed by cerebellar Purkinje cells and neurons in the cerebellar nuclei and vestibular nuclei of the Long-Evans rat. In control rats, these PKCs are distributed symmetrically in the flocculonodular-lobe Purkinje cells. Behavioral recovery from vestibular dysfunction produced by unilateral labyrinthectomy (UL) is accompanied by asymmetric expression of PKC isoforms in these regions within 6 hr after UL. These expression changes were localized within parasagittal regions of the flocculus and nodulus. The distribution of PKC␣, -␥, and -␦ were identical, suggesting that they are coregulated in cerebellar Purkinje cells during this early compensatory period. The pattern of Purkinje cell PKC expression returned to the control, symmetric distribution within 24 hr after UL. It is hypothesized that these regional changes in Purkinje cell PKC expression are an early intracellular signal contributing to vestibular compensation. In particular, regulation of PKC expression may contribute to changes in the efficacy of cerebellar synaptic plasticity during the acute post-UL period.

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Parasagittal zonal pattern of olivo-nodular projections in rabbit cerebellum

Cited by 79 publications

References 21 publications

Topographical organization of inferior olive cells projecting to translation and rotation zones in the vestibulocerebellum of pigeons

Topographical organization of inferior olive cells projecting to translation and rotation zones in the vestibulocerebellum of pigeons

Constitutive expression of the 25-kDa heat shock protein Hsp25 reveals novel parasagittal bands of Purkinje cells in the adult mouse cerebellar cortex

Transient Changes in Flocculonodular Lobe Protein Kinase C Expression during Vestibular Compensation

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