Paraquat-induced oxidative stress response during amphibian early embryonic development

Mussi, María Alejandra; Calcaterra, Nora B.

doi:10.1016/j.cbpc.2009.11.003

Cited by 20 publications

(20 citation statements)

References 34 publications

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“…The malformations in embryos exposed to OSPW are consistent with those caused by oxidative stress (Deng et al, 2009;Mussi and Calcaterra, 2010;Bui et al, 2012). Oxidative stress results when antioxidant defense mechanisms become saturated, and concentrations of ROS exceed the levels produced during normal functioning of cells.…”

Section: Discussionsupporting

confidence: 61%

Toxicity of untreated and ozone-treated oil sands process-affected water (OSPW) to early life stages of the fathead minnow (Pimephales promelas)

He¹,

Patterson²,

Wang³

et al. 2012

Water Research

147

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Section: Discussionsupporting

confidence: 61%

Toxicity of untreated and ozone-treated oil sands process-affected water (OSPW) to early life stages of the fathead minnow (Pimephales promelas)

He¹,

Patterson²,

Wang³

et al. 2012

Water Research

147

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“…Firstly, many pollutants accumulate in the body and can thereby add up and cause pathologies at higher ages. Secondly, although adults can show these accumulating effects, juveniles can have more severe consequences if exposed to pollutants during critical time windows during development, for example, morphological malformations, developmental programming defects, and prenatal death have been shown (e.g., Eeva et al, 2000;Nunes et al, 2001;Velickovic, 2004;Evers et al, 2008;Mussi and Calcaterra, 2010). In the present study, adults had significantly higher oxidative stress when living in the polluted environment, but juveniles and embryos showed no effect.…”

Section: Discussionmentioning

confidence: 50%

Pollution and Its Impact on Wild Animals: A Meta-Analysis on Oxidative Stress

Isaksson

2010

EcoHealth

137

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Oxidative stress is the unifying feature underlying the toxicity of anthropogenic pollution (e.g., heavy metals, polycyclic aromatic hydrocarbons, and nitrogen-oxides) and the ultimate culprit in the development of many diseases. Yet, there has been no attempt to summarize the published data on wild terrestrial animals to reveal general trends regarding the effects of pollution on oxidative stress. The main findings of this meta-analysis reveal that, as predicted, there is an overall increase in oxidative stress when exposed to pollution. This is mainly due to a weak overall increase of oxidative damages, although there is some variation across taxa. The reduced form of glutathione (GSH) and its associated enzymes are the most reliable biomarkers. This result is important when choosing biomarkers and when using less-invasive sampling of endangered species, or for longitudinal approaches. To be able to predict future population outcomes, possible treatments, but also evolutionary responses to a changing environment, a greater integration of biotic factors such as temperature, bioavailability of toxic elements, and species-specific responses are needed.

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“…2b), which may be related to cell antioxidant mechanisms still capable of tackling the overproduction of this ROS. It has been reported that certain paraquat concentrations induce antioxidant mechanisms, both enzymatic and non-enzymatic, in plant and animal cells (Ananieva et al 2004;Cochón et al 2007;Liu et al 2009;Mussi and Calcaterra 2010;Qian et al 2009). However, the antioxidant capacity of cells may be overwhelmed after the exposure to high herbicide concentration.…”

Section: Discussionmentioning

confidence: 99%

Flow cytometric analysis to evaluate physiological alterations in herbicide-exposed Chlamydomonas moewusii cells

et al. 2011

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Investigation of herbicide toxicology in non-target aquatic primary producers such as microalgae is of great importance from an ecological point of view. In order to study the toxicity of the widely used herbicide paraquat on freshwater green microalga Chlamydomonas moewusii, physiological changes associated with 96 h-exposures to this pollutant were monitored using flow cytometry (FCM) technique. Intracellular reactive oxygen species concentration, cytoplasmic membrane potential, metabolic activity and cell protein content were monitored to evaluate the toxicological impact of paraquat on algal physiology. Results showed that herbicide paraquat induced oxidative stress in C. moewusii cells, as it indicated the increase of both superoxide anion and hydrogen peroxide levels observed in non-chlorotic cells of cultures exposed to increasing herbicide concentrations. Furthermore, a progressive increase in the percentage of depolarised cells and a decrease in the metabolic activity level were observed in response to paraquat when non-chlorotic cells were analysed. Chlorotic cells were probably non-viable cells, based on the cytoplasmic membrane depolarisation, its metabolically non-active state and its drastically reduced protein content. In view of the obtained results, we have concluded that a range of significant physiological alterations, detected by flow cytometry, occur when C. moewusii, an ubiquitous microalga in freshwater environments, is challenged with environmentally relevant concentrations of the herbicide paraquat.

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Paraquat-induced oxidative stress response during amphibian early embryonic development

Cited by 20 publications

References 34 publications

Toxicity of untreated and ozone-treated oil sands process-affected water (OSPW) to early life stages of the fathead minnow (Pimephales promelas)

Toxicity of untreated and ozone-treated oil sands process-affected water (OSPW) to early life stages of the fathead minnow (Pimephales promelas)

Pollution and Its Impact on Wild Animals: A Meta-Analysis on Oxidative Stress

Flow cytometric analysis to evaluate physiological alterations in herbicide-exposed Chlamydomonas moewusii cells

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