Pollution and Its Impact on Wild Animals: A Meta-Analysis on Oxidative Stress

Isaksson, Caroline

doi:10.1007/s10393-010-0345-7

Cited by 137 publications

(110 citation statements)

References 37 publications

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“…We also predicted (4) that the adapter species would show a more pronounced difference between the urban and rural environments, given that the exploiter species rely on human-provided foods also in the rural habitat. In addition, we predicted (5) that urban birds should have higher MDA due to higher environmentally induced oxidative stress (Isaksson, 2010). Furthermore, we predicted (6) that if a high ω-6/ω-3 PUFA ratio produces pro-oxidants via pro-inflammatory responses, a positive association between the ω-6/ω-3 PUFA ratio and MDA would be revealed in the urban, but not in the rural, environment.…”

Section: Introductionmentioning

confidence: 93%

“…This has repeatedly been shown to result in changes in traits with potential fitness links, e.g., behavior, morphology, and reproductive investment (Gorissen et al, 2005;Isaksson et al, 2005;Fuller et al, 2007;Kempenaers et al, 2010). Likewise, several molecular and physiological parameters are also affected by the urban environment, including altered gene expression, endocrine changes, increased oxidative stress, and accelerated telomere attrition (Partecke et al, 2006;Isaksson, 2010;Atwell et al, 2012;Dominoni et al, 2013;Salmón et al, 2016;Watson et al, 2017). Such changes to blood-and cell chemistry may be exacerbated by a suboptimal diet in urban populations (Romieu et al, 2008;Isaksson et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

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Species-Dependent Effects of the Urban Environment on Fatty Acid Composition and Oxidative Stress in Birds

et al. 2017

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Ecological impacts of urbanization include the loss of biodiversity and changes in species composition and population densities. However, how the urban environment affects fundamental physiological parameters is largely unknown. Here, we investigated physiological components related to health and nutrition, namely, plasma fatty acids (FA) and lipid peroxidation at inter-habitat and interspecific levels. Specifically, we compared four passerine bird species-the great tit (Parus major), the blue tit (Cyanistes caeruleus), the house sparrow (Passer domesticus), and the tree sparrow (P. montanus)-from urban and rural environments. Significant interactions between species and habitat were revealed for the majority of the FAs. Interestingly, the observed inter-habitat variation in FAs was frequently in opposite directions when comparing species from the two families (tits, Paridae; sparrows, Passeridae). These patterns suggest that sparrows and tits feed on different food sources, or modulate their FA metabolism differently, across the urban-rural gradient. By using canonical discriminant analyses (CDA), we further demonstrated species-specific signals in FA composition, with misclassification of species being <1% within habitats and <7% between habitats. Finally, the urban-rural FA differences between species and families were manifested in two indices of health. Firstly, urban blue tits had a higher total ω-6/ω-3 polyunsaturated FA ratio than rural conspecifics, which is believed to increase inflammatory responses. Secondly, urban sparrows of both species showed higher lipid peroxidation indices (indicating a higher susceptibility to lipid peroxidation if exposed to pro-oxidants), and consequently, a higher level of lipid peroxidation compared to their rural conspecifics. Collectively, the speciesand habitat-specific differences in plasma FA composition, which are linked to nutrition and metabolism, suggest that the urban environment affect tits and sparrows primarily via two different pathways-inflammation and oxidative stress, respectively,-with potential consequences for the health of urban populations.

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Section: Introductionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Species-Dependent Effects of the Urban Environment on Fatty Acid Composition and Oxidative Stress in Birds

et al. 2017

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“…The regulation of oxidative damage may act as an underlying driver of aging or longevity (Montgomery et al, 2012;Selman et al, 2012). Other reviews have focused on the regulation of RS production from an evolutionary perspective (Costantini, 2008(Costantini, , 2014Costantini et al, 2010b;Monaghan et al, 2009;Speakman, 2008;Speakman et al, 2015;Williams et al, 2010), or on the role of RS in conservation physiology (Beaulieu and Costantini, 2014;Isaksson, 2010), in signaling (Garratt and Brooks, 2012) and as an important indicator of bird health for field ornithologists (Hutton and McGraw, 2016;, or on the importance of dietary antioxidants for wild animals (e.g. Beaulieu and Schaefer, 2013;Catoni et al, 2008b).…”

Section: Introductionmentioning

confidence: 99%

The role of the antioxidant system during intense endurance exercise: lessons from migrating birds

Cooper-Mullin

McWilliams

2016

Journal of Experimental Biology

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During migration, birds substantially increase their metabolic rate and burn fats as fuel and yet somehow avoid succumbing to overwhelming oxidative damage. The physiological means by which vertebrates such as migrating birds can counteract an increased production of reactive species (RS) are rather limited: they can upregulate their endogenous antioxidant system and/or consume dietary antioxidants ( prophylactically or therapeutically). Thus, birds can alter different components of their antioxidant system to respond to the demands of long-duration flights, but much remains to be discovered about the complexities of RS production and antioxidant protection throughout migration. Here, we use bird migration as an example to discuss how RS are produced during endurance exercise and how the complex antioxidant system can protect against cellular damage caused by RS. Understanding how a bird's antioxidant system responds during migration can lend insights into how antioxidants protect birds during other life-history stages when metabolic rate may be high, and how antioxidants protect other vertebrates from oxidative damage during endurance exercise.

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“…We selected the nematode Caenorhabditis elegans as a convenient model organism. Caenorhabditis elegans is a widely distributed opportunistic colonizer of microbe-rich habitats (Frézal and Félix, 2015), where it is likely exposed to daily fluctuations in temperature and to both naturally occurring and anthropogenic toxins that increase oxidative stress (Isaksson, 2010;Watanabe et al, 2004). Its small size (∼1 mm), short lifespan (∼3-4 weeks) and large brood size simplify its culture in the lab (Brenner, 1974).…”

Section: Introductionmentioning

confidence: 99%

Inhibition of the oxidative stress response by heat stress inCaenorhabditis elegans

Crombie

Tang

Choe

et al. 2016

Journal of Experimental Biology

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It has long been recognized that simultaneous exposure to heat stress and oxidative stress shows a synergistic interaction that reduces organismal fitness, but relatively little is known about the mechanisms underlying this interaction. We investigated the role of molecular stress responses in driving this synergistic interaction using the nematode Caenorhabditis elegans. To induce oxidative stress, we used the pro-oxidant compounds acrylamide, paraquat and juglone. As expected, we found that heat stress and oxidative stress interact synergistically to reduce survival. Compared with exposure to each stressor alone, during simultaneous sublethal exposure to heat stress and oxidative stress the normal induction of key oxidative-stress response (OxSR) genes was generally inhibited, whereas the induction of key heat-shock response (HSR) genes was not. Genetically activating the SKN-1-dependent OxSR increased a marker for protein aggregation and decreased whole-worm survival during heat stress alone, with the latter being independent of HSF-1. In contrast, compared with wild-type worms, inactivating the HSR by HSF-1 knockdown, which would be expected to decrease basal heat shock protein expression, increased survival during oxidative stress alone. Taken together, these data suggest that, in C. elegans, the HSR and OxSR cannot be simultaneously activated to the same extent that each can be activated during a single stressor exposure. We conclude that the observed synergistic reduction in survival during combined exposure to heat stress and oxidative stress is due, at least in part, to inhibition of the OxSR during activation of the HSR.

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Pollution and Its Impact on Wild Animals: A Meta-Analysis on Oxidative Stress

Cited by 137 publications

References 37 publications

Species-Dependent Effects of the Urban Environment on Fatty Acid Composition and Oxidative Stress in Birds

Species-Dependent Effects of the Urban Environment on Fatty Acid Composition and Oxidative Stress in Birds

The role of the antioxidant system during intense endurance exercise: lessons from migrating birds

Inhibition of the oxidative stress response by heat stress inCaenorhabditis elegans

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