Paraoxonases, oxidative stress, and breast cancer

Eraldemir, Fatma Ceyla; Korak, Tuğcan

doi:10.1016/b978-0-12-819547-5.00001-8

Cited by 4 publications

(2 citation statements)

References 51 publications

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“…Another flaw of the study is the lack of female representation in the group. However, we felt that estrogen changes during the menstrual cycle could be a confounding factor in this experiment since estrogen was previously shown to have a stimulating effect on the PON1 enzyme [ 62 ].…”

Section: Discussionmentioning

confidence: 99%

Effect of Exercise Repetitions on Arylesterase Activity of PON1 in Plasma of Average-Trained Men—The Dissociation between Activity and Concentration

et al. 2023

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Exercise may increase the antioxidant capacity of plasma by stimulating antioxidant enzymes. The study aimed to measure the effect of three repetitions of acute exercise on arylesterase (ARE) activity of the paraoxonase 1 (PON1) enzyme. Eleven average-trained men (age 34.0 ± 5.2 years) completed three treadmill runs. ARE activity in plasma was evaluated spectrophotometrically and compared with PON1 concentration (PON1c), paraoxonase (PON) activity, and high-density lipoprotein cholesterol (HDL-C) at rest and after exercise. In all repetitions of the exercise, ARE activity remained stable, and ARE activity standardized for PON1c (ARE/PON1c) was lower post- than pre-exercise. The ARE/PON1c ratio changes returned to baseline levels during rest after each exercise session. Pre-exercise ARE activity correlated negatively with post-exercise C-reactive protein (CRP) (ρ = −0.35, p = 0.049), white blood cell count (WBC) (ρ = −0.35, p = 0.048), polymorphonuclear leukocytes (PMN) (ρ = −0.37, p = 0.037), and creatine kinase (CK) (ρ = −0.37, p = 0.036). ARE activity may be depleted under conditions of oxidative stress, as increases in PON1c during acute exercise did not result in parallel increases in ARE activity. No adaptation of the response of ARE activity to exercise was detected in subsequent exercise sessions. Individuals with lower pre-exercise ARE activity may develop a higher inflammatory response to strenuous exercise.

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Section: Discussionmentioning

confidence: 99%

Effect of Exercise Repetitions on Arylesterase Activity of PON1 in Plasma of Average-Trained Men—The Dissociation between Activity and Concentration

et al. 2023

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“…It is known that calcium-dependent hydrolases-paraoxonase (PON)-are involved in the process of antioxidant oxidation and are the products of three genes: PON1, PON2 and PON3 [221]. A number of PON1 polymorphisms lead to decreased serum PON1 activity, which contributes to increased oxidative stress.…”

Section: Inflammation and Oxidative Stress In Breast Cancermentioning

confidence: 99%

Oxidative Stress in Breast Cancer: A Biochemical Map of Reactive Oxygen Species Production

Bel’skaya,

Dyachenko

2024

CIMB

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This review systematizes information about the metabolic features of breast cancer directly related to oxidative stress. It has been shown those redox changes occur at all levels and affect many regulatory systems in the human body. The features of the biochemical processes occurring in breast cancer are described, ranging from nonspecific, at first glance, and strictly biochemical to hormone-induced reactions, genetic and epigenetic regulation, which allows for a broader and deeper understanding of the principles of oncogenesis, as well as maintaining the viability of cancer cells in the mammary gland. Specific pathways of the activation of oxidative stress have been studied as a response to the overproduction of stress hormones and estrogens, and specific ways to reduce its negative impact have been described. The diversity of participants that trigger redox reactions from different sides is considered more fully: glycolytic activity in breast cancer, and the nature of consumption of amino acids and metals. The role of metals in oxidative stress is discussed in detail. They can act as both co-factors and direct participants in oxidative stress, since they are either a trigger mechanism for lipid peroxidation or capable of activating signaling pathways that affect tumorigenesis. Special attention has been paid to the genetic and epigenetic regulation of breast tumors. A complex cascade of mechanisms of epigenetic regulation is explained, which made it possible to reconsider the existing opinion about the triggers and pathways for launching the oncological process, the survival of cancer cells and their ability to localize.

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Norbixin, a natural dye that improves serum lipid profile in rabbits and prevents LDL oxidation

Somacal

Quatrin

Ruviaro

et al. 2022

Food Research International

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Paraoxonases, oxidative stress, and breast cancer

Cited by 4 publications

References 51 publications

Effect of Exercise Repetitions on Arylesterase Activity of PON1 in Plasma of Average-Trained Men—The Dissociation between Activity and Concentration

Effect of Exercise Repetitions on Arylesterase Activity of PON1 in Plasma of Average-Trained Men—The Dissociation between Activity and Concentration

Oxidative Stress in Breast Cancer: A Biochemical Map of Reactive Oxygen Species Production

Norbixin, a natural dye that improves serum lipid profile in rabbits and prevents LDL oxidation

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