Norbixin, a natural dye that improves serum lipid profile in rabbits and prevents LDL oxidation

Somacal, Sabrina; Quatrin, Andréia; Ruviaro, Amanda Roggia; Conte, Lisiane; Silva, Dariane T. da; Roehrs, Miguel; Veiga, Marcelo Leite da; Duarte, Marta Medeiros Frescura; de, Andreza Fabro; Augusti, Paula Rossini; Emanuelli, Tatiana

doi:10.1016/j.foodres.2022.111522

Cited by 3 publications

(2 citation statements)

References 62 publications

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“…Regarding carotenoid degradation, a similar separation between the different systems as for the oxidative stability could be made, showing the association between oxidative stability and carotenoid degradation. In the oxidatively stable systems, carotenoids were present throughout the storage period, whereas they were absent in the oxidizing systems ( Somacal et al, 2022 ). Moreover, the degradation illustrates the carotenoids’ antioxidative role.…”

Section: Natural Antioxidantsmentioning

confidence: 99%

RETRACTED: Integrated the embedding delivery system and targeted oxygen scavenger enhances free radical scavenging capacity

2023

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Section: Natural Antioxidantsmentioning

confidence: 99%

RETRACTED: Integrated the embedding delivery system and targeted oxygen scavenger enhances free radical scavenging capacity

2023

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“…Regarding RQ2, the carotenoid has shown atheroprotective potential, being beneficial in the control of risk factors for atherosclerosis, the main cause of the most common types of cardiovascular disease, as well as in the prevention and treatment of cardiometabolic syndrome (CMetS) (Jebari-Benslaiman et al, 2022;Santos et al, 2002;Somacal et al, 2022). Experimental results have shown that the carotenoid has the potential to act as a PPAR-γ agonist (Goto et al, 2010;Rohini et al, 2018;Wang et al, 2014), a substance of interest for the treatment of CMetS, inhibits the oxidation of human low-density lipoprotein (LDL) in vitro and improves the serum lipid profile in rabbits, increasing the levels of high-density lipoprotein and reducing the levels of triglycerides, autoantibodies, oxidized LDL, atherogenic index, as well as inhibiting lipid and protein oxidation in the aortic tissue of the animals (Somacal et al, 2022), as questioned in RQ3. Another study showed that norbixin inhibits lipid peroxidation, alters plasma lipid levels and paraoxonase/alisterase activities in in vivo tests under conditions of high fat intake, but as noted in RQ4, the doses tested were high and would not be suitable for humans (Santos et al, 2002).…”

Section: Cardiovascular Disease Treatmentmentioning

confidence: 99%

A systematic literature review on the pharmacological applications of the carotenoid norbixin

Leal Alves,

Santos Miranda,

Leal Alves

et al. 2024

PRW

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Carotenoids play essential roles in human health and can fight and prevent diseases. One carotenoid that is currently attracting scientific interest, particularly for its antioxidant properties, is norbixin. Studies related to its use in the treatment of diseases have become increasingly present in the medical field. This systematic literature review aimed to investigate and gather studies on the pharmacological activity of norbixin for health benefits and the treatment of diseases. Four databases were consulted: Web of Science, PubMed, Scopus, and ScienceDirect. Articles were extracted using a combination of keywords such as 'norbixin', 'antioxidant', 'diseases', 'in vitro', 'in vivo', etc. A total of 173 articles were identified. After applying the inclusion and exclusion criteria, 21 were selected for inclusion in this review. Studies have shown that norbixin, alone or in combination with other treatments, may be effective in DNA protection, tissue engineering, bone repair, and the prevention and treatment of age-related macular degeneration and cardiovascular disease. These results provide a solid basis for further studies aimed at exploring the pharmacological properties of norbixin and enabling its use in therapeutic applications.

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Evaluation of Lipid Profile and Oxidative Stress of Workers in Fast Food Restaurants and The Risk of Atherosclerosis

Mohammed,

Al-Fartusie,

Thani

2024

Al-Mustansiriyah Journal of Science

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Cooking fumes and biomass smoke pose significant threats to air degradation and human health, especially to people who work in this field on a daily basis, due to the large amounts of hazardous pollutants released from grilling activities. Chronic exposure to these fumes is associated with a risk of inflammation and oxidative stress, which can increase the risk of atherosclerosis. In this study, the lipid profile Glutathion (GSH) and Malondialdehyde (MDA) of workers in fast food restaurants and patients with atherosclerosis were evaluated. The study included 40 Atherosclerosis patients, 40 fast food workers, and 40 healthy individuals as a control group, the ages ranges of (20-40) years. The obtained results indicated a significant increase in cholesterol, triglycerides, LDL, and VLDL and a decrease in HDL (p < 0.01) in patients and fast-food workers compared to control group. The results also indicated a significant increase in the level of MDA, and a significant decrease in the level of GSH for patients and fast-food workers compared to the control. In conclusion, it appears that fast food workers experience oxidative stress and disruption in lipid metabolism that may increase the risk of atherosclerosis. Therefore, safety and quality control measures must be strengthened to reduce the occupational risks of fast-food restaurant workers.

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Norbixin, a natural dye that improves serum lipid profile in rabbits and prevents LDL oxidation

Cited by 3 publications

References 62 publications

RETRACTED: Integrated the embedding delivery system and targeted oxygen scavenger enhances free radical scavenging capacity

RETRACTED: Integrated the embedding delivery system and targeted oxygen scavenger enhances free radical scavenging capacity

A systematic literature review on the pharmacological applications of the carotenoid norbixin

Evaluation of Lipid Profile and Oxidative Stress of Workers in Fast Food Restaurants and The Risk of Atherosclerosis

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