Paraoxonase1 55 and 192 gene polymorphisms in an Egyptian population with diabetic complications

Helaly, Mohamed; Abdel-Khalek, A.; Abdel-Hafez, Hala A.; Soliman, Ahmed A.; Daoud, Eid M.; Lotfy, Zakaria Fawzy

doi:10.1007/s13410-013-0146-y

Cited by 2 publications

(6 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Regarding the paraoxonase 1 Q192R polymorphism, paraoxonase 1 activity was different from genotypes, with the highest level in genotype RR in an Egyptian population, and the lowest level in genotype QQ in an African population . Paraoxonase 1 activity was significantly lower in the genotype QQ of paraoxonase 1 Q192R polymorphism than genotypes QR and RR in the patients with diabetic macroangiopathy . Meanwhile, paraoxonase 1 activity was significantly lower in the genotype LL of the paraoxonase 1 L55M polymorphism than genotypes LM and MM in the patients with diabetic macroangiopathy and microangiopathy in an Egyptian population, while no difference between L and M alleles .…”

Section: Discussionmentioning

confidence: 87%

“…Paraoxonase 1 activity was significantly lower in the genotype QQ of paraoxonase 1 Q192R polymorphism than genotypes QR and RR in the patients with diabetic macroangiopathy . Meanwhile, paraoxonase 1 activity was significantly lower in the genotype LL of the paraoxonase 1 L55M polymorphism than genotypes LM and MM in the patients with diabetic macroangiopathy and microangiopathy in an Egyptian population, while no difference between L and M alleles . So the effect of interaction between paraoxonase 1 activity and genetic polymorphisms on the susceptibility of DM regarding the ethnic difference needs to be studied in the further.…”

Section: Discussionmentioning

confidence: 92%

“…Two studies used the same case series, respectively, so the most recent publication was included . Lastly, 36 case‐control studies were included in the meta‐analyses . Thirty‐four publications were written in English, and two were written in Chinese .…”

Section: Resultsmentioning

confidence: 99%

“…As shown in Table , thirty‐four articles studied the association between paraoxonase 1 activity and risk of DM included 3474 DM patients and 3246 controls. Twenty‐one studies were performed in Asian countries, and other thirteen in non‐Asian . Twenty‐three articles were focused on T2DM, one on T1DM and T2DM, four on TDM, two on GDM or one on NIDDM, and three were unknown.…”

Section: Resultsmentioning

confidence: 99%

“…Genetic polymorphisms of paraoxonase 1 have been demonstrated to affect the paraoxonase 1 activity . Regarding the paraoxonase 1 Q192R polymorphism, paraoxonase 1 activity was different from genotypes, with the highest level in genotype RR in an Egyptian population, and the lowest level in genotype QQ in an African population . Paraoxonase 1 activity was significantly lower in the genotype QQ of paraoxonase 1 Q192R polymorphism than genotypes QR and RR in the patients with diabetic macroangiopathy .…”

Section: Discussionmentioning

confidence: 97%

See 4 more Smart Citations

The association between paraoxonase 1 activity and the susceptibilities of diabetes mellitus, diabetic macroangiopathy and diabetic microangiopathy

Zhong

2018

J Cellular Molecular Medi

View full text Add to dashboard Cite

We carried out this meta‐analysis to explore the influence of paraoxonase 1 activity on the susceptibility of diabetes mellitus (DM), diabetic macroangiopathy and diabetic microangiopathy. Relevant studies were identified from PubMed, Web of Science and CNKI without language limitation, following the inclusion and exclusion criteria. Statistical analyses were implemented with the STATA 12.0 statistical software. Thirty‐six case‐control studies were included in the meta‐analyses, in which 35 for the association between paraoxonase 1 activity and DM risk, 8 for diabetic macroangiopathy and 7 for diabetic microangiopathy. Paraoxonase 1 activity was significantly associated with the susceptibility of DM in pooled population (SMD = −1.37, 95% CI = −1.79 ∼ −0.96, P = .000), and Asians (SMD = −2.00, 95% CI = −2.56 ∼ −1.44, P = .000), but not in non‐Asians (SMD = −0.44, 95% CI = −0.91 ∼ 0.03, P = .069). However, marked heterogeneity was existed (I2 = 98.10%, P = .000) and subgroup analyses failed to investigate the sources of heterogeneity. Then, meta‐regression was performed and found that ethnicity could explain the observed between‐study heterogeneity (P = .002). Meanwhile, significant associations were found between paraoxonase 1 activity and diabetic macroangiopathy (SMD = −1.06, 95% CI = −1.63 ∼ −0.48, P = .000) and diabetic microangiopathy (SMD = −0.72, 95% CI = −1.32 ∼ −0.13, P = .018). In conclusion, paraoxonase 1 activity plays important roles in the risk of DM, diabetic macroangiopathy and microangiopathy with ethnicity differences. Further studies with large sample and well design are needed to confirm these results.

show abstract

Section: Discussionmentioning

confidence: 87%

Section: Discussionmentioning

confidence: 92%

Section: Resultsmentioning

confidence: 99%