The association between paraoxonase 1 activity and the susceptibilities of diabetes mellitus, diabetic macroangiopathy and diabetic microangiopathy

Abstract

We carried out this meta‐analysis to explore the influence of paraoxonase 1 activity on the susceptibility of diabetes mellitus (DM), diabetic macroangiopathy and diabetic microangiopathy. Relevant studies were identified from PubMed, Web of Science and CNKI without language limitation, following the inclusion and exclusion criteria. Statistical analyses were implemented with the STATA 12.0 statistical software. Thirty‐six case‐control studies were included in the meta‐analyses, in which 35 for the association between paraoxonase 1 activity and DM risk, 8 for diabetic macroangiopathy and 7 for diabetic microangiopathy. Paraoxonase 1 activity was significantly associated with the susceptibility of DM in pooled population (SMD = −1.37, 95% CI = −1.79 ∼ −0.96, P = .000), and Asians (SMD = −2.00, 95% CI = −2.56 ∼ −1.44, P = .000), but not in non‐Asians (SMD = −0.44, 95% CI = −0.91 ∼ 0.03, P = .069). However, marked heterogeneity was existed (I2 = 98.10%, P = .000) and subgroup analyses failed to investigate the sources of heterogeneity. Then, meta‐regression was performed and found that ethnicity could explain the observed between‐study heterogeneity (P = .002). Meanwhile, significant associations were found between paraoxonase 1 activity and diabetic macroangiopathy (SMD = −1.06, 95% CI = −1.63 ∼ −0.48, P = .000) and diabetic microangiopathy (SMD = −0.72, 95% CI = −1.32 ∼ −0.13, P = .018). In conclusion, paraoxonase 1 activity plays important roles in the risk of DM, diabetic macroangiopathy and microangiopathy with ethnicity differences. Further studies with large sample and well design are needed to confirm these results.

Circulating Oxidative Stress Biomarkers in Clinical Studies on Type 2 Diabetes and Its Complications

“…Data referring to antioxidant defence systems are more inconclusive since they have been found either decreased or increased. Emerging evidence also points out the relationship between serum PON1 and HO1 in T2DM and its complications, and a recent meta-analysis demonstrated that PON1 was significantly associated with the susceptibility of T2DM and to the development of macro- and microangiopathy [115].…”

Multivariate analysis of incision infection after posterior lumbar surgery in diabetic patients

“…Among the blood glucose-related indicators, preoperative HbA1c, postoperative FBG, and postoperative PBG were risk factors for incision infection after lumbar surgery in diabetic patients. On the one hand, Wu et al [15] showed that diabetic patients with poor blood sugar management often have microvascular disease, which caused local insufficiency of blood supply. On the other hand, hyperglycemia increases plasma osmotic pressure, inhibits the phagocytic ability of white blood cells, and reduces the body's anti-infective ability.…”

Paraoxonase 1 and atherosclerosis‐related diseases

“…Given the fact that CVD is the main risk factor for mortality in DM patients, it is unsurprising that the activity and polymorphism of PON1 have been studied in diabetic pathophysiology over the last two decades. A recently published meta‐analysis showed association of reduced PON1 activity with DM and development of chronic DM complications . Some studies failed to see changes in PON1 levels in diabetics compared with controls, but without a doubt, PON1activity in diabetics was lower .…”

“…A recently published meta-analysis showed association of reduced PON1 activity with DM and development of chronic DM complications. 75 Some studies failed to see changes in PON1 levels in diabetics compared with controls, but without a doubt, PON1activity in diabetics was lower. 76 Reduced PON1 activity in diabetics is worthy of further research due to several reasons.…”