Paraoxonase gene cluster is a genetic marker for early microvascular complications in Type 1 diabetes

Kao, Yan-Lin; Donaghue, Kim C.; Chan, Albert; Bennetts, Bruce; Knight, John; Silink, Martin

doi:10.1046/j.1464-5491.2002.00660.x

Cited by 46 publications

(23 citation statements)

References 25 publications

(26 reference statements)

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“…Kao ve ark. 25 Avustralyalı tip 1 diyabetli adölesanlarda Met54Leu polimorfizmi ile diyabetik retinopati arasında güçlü bir ilişki bulmuşlardır. Başka bir çalışmada tip 1 diyabeti ve PON1 geni 54. pozisyonda L/L polimorfizmi olan bireylerin retinal komplikasyonlara daha yatkın olduğu bulunmuştur.…”

Section: Discussionunclassified

Diyabetik ve Diyabetik Olmayan Katarakt Hastalarında Hümör Aközde ve Serumda Total Oksidatif Stres, Total Antioksidan Kapasite, Paraoksonaz, Arilesteraz ve Lipidperoksidaz Seviyelerinin Karşılaştırılması

Caner¹,

Özeç²,

Aydın³

et al. 2012

tjo

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Section: Discussionunclassified

Diyabetik ve Diyabetik Olmayan Katarakt Hastalarında Hümör Aközde ve Serumda Total Oksidatif Stres, Total Antioksidan Kapasite, Paraoksonaz, Arilesteraz ve Lipidperoksidaz Seviyelerinin Karşılaştırılması

Caner¹,

Özeç²,

Aydın³

et al. 2012

tjo

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“…Thus, our data suggest the high-risk ACR group, screened through ACR, may indeed be a population predisposed to earlier onset of complications and likely to benefit from earlier intervention. Current evidence supports both genetic and metabolic mechanisms that protect against and predispose to diabetes complications [9,10,27]. However, a clinically measurable and reproducible biomarker associated with such risk has been elusive.…”

Section: Discussionmentioning

confidence: 99%

The Adolescent Cardio-Renal Intervention Trial (AdDIT): retinal vascular geometry and renal function in adolescents with type 1 diabetes

et al. 2018

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Aims/hypothesis We examined the hypothesis that elevation in urinary albumin creatinine ratio (ACR) in adolescents with type 1 diabetes is associated with abnormal retinal vascular geometry (RVG) phenotypes. Methods A cross-sectional study at baseline of the relationship between ACR within the normoalbuminuric range and RVG in 963 adolescents aged 14.4 ± 1.6 years with type 1 diabetes (median duration 6.5 years) screened for participation in AdDIT. A validated algorithm was used to categorise log 10 ACR into tertiles: upper tertile ACR was defined as 'high-risk' for future albuminuria and the lower two tertiles were deemed 'low-risk'. RVG analysis, using a semi-automated computer program, determined retinal vascular calibres (standard and extended zones) and tortuosity. RVG measures were analysed continuously and categorically (in quintiles: Q1-Q5) for associations with log 10 ACR and ACR risk groups. Results Greater log 10 ACR was associated with narrower vessel calibres and greater tortuosity. The high-risk group was more likely to have extended zone vessel calibres in the lowest quintile (arteriolar Q1 vs Q2 67, 3.40]). The effects of retinal vascular calibres and tortuosity were additive such that the participants with the narrowest and most tortuous vessels were more likely to be in the high-risk group (OR 3.32 [1.84, 5.96]). These effects were independent of duration, blood pressure, BMI and blood glucose control.A list of AdDIT investigators is included in the Appendix and members of the Trial Steering Committee are listed in the Acknowledgements.

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“…The A/G148 polymorphism has been associated with variations in total and LDL-C levels, FPG levels, and birth weight (Hegele et al, 1997(Hegele et al, , 1998. The polymorphism at position 311 has been associated with coronary artery disease, ischemic stroke in patients with type 2 diabetes mellitus, late-onset Alzheimer's disease, and reduced bone mass in postmenopausal women (Kao et al, 2002;Chen et al, 2003;Yamada et al, 2003;Martinelli et al, 2004;Shi et al, 2004). Our study showed that the PON2 C allele is a significant risk factor for CAAD in the Xinjiang Han and Uighur people with hypertension.…”

Section: Discussionmentioning

confidence: 99%

Association of paraoxonase polymorphisms with carotid artery atherosclerosis in essential hypertension patients

Han¹,

Xu²,

Xue³

et al. 2013

Genet. Mol. Res.

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ABSTRACT. We investigated the relationships between paraoxonase genetic polymorphisms and essential hypertension in carotid artery atherosclerotic patients. The study included 353 Han participants and 240 Uighur participants from Xinjiang; they were further divided into two groups: essential hypertension with carotid artery atherosclerosis (CAAD group) and essential hypertension without carotid artery atherosclerosis (control group). Genotypes were detected by PCR, followed by restriction analyses with specific endonucleases. In Han people, the M allele frequency was significantly higher in the CAAD group than in the control group. The CC/CS genotype and C allele frequencies were significantly higher in the CAAD group than in the control group. Logistic regression analysis demonstrated that PON1 55M allele [odds ratio (OR) = 1.889] and PON2 311C allele (OR = 1.692) are independent risk factors for CAAD. Combined genotype analysis showed that PON1 55M and PON2 311C alleles are independent risk 5175 ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 12 (4): 5174-5185 (2013) Atherosclerosis in essential hypertension patients factors for CAAD (OR = 1.428). In the Uighur population, the CC/ CS genotype and C allele frequencies were significantly higher in the CAAD group than in the control group. Logistic regression analysis demonstrated that the PON2 311C allele is an independent risk factor for CAAD. We conclude that the PON1 55M and PON2 311C alleles are independent risk factors for CAAD in essential hypertension patients from the Xinjiang Han population. We also conclude that the PON2 311C allele is a risk factor for CAAD in essential hypertension patients from the Xinjiang Uighur population.

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Paraoxonase gene cluster is a genetic marker for early microvascular complications in Type 1 diabetes

Abstract: This study supports the hypothesis that diabetic microangiopathy is genetically heterogeneous. PON1 Leu/Leu increases the risk for retinopathy and PON2 Ser/Ser increases the risk for microalbuminuria.

Cited by 46 publications

References 25 publications

Diyabetik ve Diyabetik Olmayan Katarakt Hastalarında Hümör Aközde ve Serumda Total Oksidatif Stres, Total Antioksidan Kapasite, Paraoksonaz, Arilesteraz ve Lipidperoksidaz Seviyelerinin Karşılaştırılması

Diyabetik ve Diyabetik Olmayan Katarakt Hastalarında Hümör Aközde ve Serumda Total Oksidatif Stres, Total Antioksidan Kapasite, Paraoksonaz, Arilesteraz ve Lipidperoksidaz Seviyelerinin Karşılaştırılması

The Adolescent Cardio-Renal Intervention Trial (AdDIT): retinal vascular geometry and renal function in adolescents with type 1 diabetes

Association of paraoxonase polymorphisms with carotid artery atherosclerosis in essential hypertension patients

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