Diyabetik ve Diyabetik Olmayan Katarakt Hastalarında Hümör Aközde ve Serumda Total Oksidatif Stres, Total Antioksidan Kapasite, Paraoksonaz, Arilesteraz ve Lipidperoksidaz Seviyelerinin Karşılaştırılması

Caner, Cengiz; Özeç, Ayşe Vural; Aydın, Hüseyin; Topalkara, Ayşen; Arıcı, Mustafa Kemal; Erdoğan, Haydar; Toker, Mustafa

doi:10.4274/tjo.42.74318

Cited by 5 publications

(5 citation statements)

References 13 publications

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“…In a study conducted in order to investigate the effects of oxidative stress on the progression of DRP, Uçgun et al reported that serum TAC decreased while TOS increased in nonproliferative DRP and proliferative DRP groups in comparison to the control group [ 32 ]. Furthermore, Caner et al found that the serum TAC value was significantly lower in DRP patients than the control group [ 33 ]. The same study also reported that the serum TOS value was significantly higher in the patient group than the control group [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, Caner et al found that the serum TAC value was significantly lower in DRP patients than the control group [ 33 ]. The same study also reported that the serum TOS value was significantly higher in the patient group than the control group [ 33 ]. In line with the literature, the results of our study indicated that serum TAC level was lower in the DRP group than the control group while the serum TOS level was higher.…”

Section: Discussionmentioning

confidence: 99%

“…But the differences in TAC levels in the serum were not statistically significant. Caner et al could not find a statistically significant difference between the groups regarding TAC and TOS levels in aqueous humor [ 33 ]. In our study, there was no statistically significant difference regarding total thiol, TOS, and TAC levels in the aqueous humor of patients.…”

Section: Discussionmentioning

confidence: 99%

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The Association between Diabetic Retinopathy and Levels of Ischemia-Modified Albumin, Total Thiol, Total Antioxidant Capacity, and Total Oxidative Stress in Serum and Aqueous Humor

Kirboğa

Özeç

Dursun

et al. 2014

Journal of Ophthalmology

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Purpose. To investigate the oxidant and antioxidant status of patients with type 2 diabetes mellitus and nonproliferative diabetic retinopathy (DRP). Methods. Forty-four patients who had cataract surgery were enrolled in the study. We included 22 patients with DRP in one group and 22 patients in the control group. Samples of aqueous humor and serum were taken from all patients. Serum and aqueous ischemia-modified albumin (IMA), total thiol, total antioxidant capacity (TAC), and total oxidative stress (TOS) levels were compared in two groups. Results. Median serum IMA levels were 44.80 absorbance units in the DRP group and 40.15 absorbance units in the control group (P = 0.031). Median serum total thiol levels in the DRP group were significantly less than those in the control group (3051.13 and 3910.12, resp., P = 0.004). Mean TOS levels in the serum were 2.93 ± 0.19 in the DRP group and 2.61 ± 0.26 in the control group (P = 0.039). The differences in mean total thiol, TAC, and TOS levels in the aqueous humor and mean TAC levels in the serum were not statistically significant. Conclusion. IMA, total thiol, and TOS levels in the serum might be useful markers in monitoring the risk of DRP development.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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The Association between Diabetic Retinopathy and Levels of Ischemia-Modified Albumin, Total Thiol, Total Antioxidant Capacity, and Total Oxidative Stress in Serum and Aqueous Humor

Kirboğa

Özeç

Dursun

et al. 2014

Journal of Ophthalmology

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“…In the study conducted by Hashim and Zarina 28 to investigate the relationship between aging and diabetes and oxidative stress with cataract, ARE level was found to be significantly lower in the senile cataract group than the control group. In the study conducted by Caner et al , 27 however, no significant difference was found between the groups in terms of aqueous humor ARE value. This result was consistent with the result of this study.…”

Section: Discussionmentioning

confidence: 81%

“…There was no significant difference in terms of TAS and TOS in the aqueous humor samples of the two groups. In the study conducted by Caner et al , 27 serum TAS values were found to be lower and TOS values higher in the diabetic retinopathy group compared with the diabetic group without retinopathy and the group without other systemic diseases except for the diagnosis of cataract. Also, no statistically significant difference was reported between the diabetic group and the control group in terms of aqueous humor TAS and TOS levels.…”

Section: Discussionmentioning

confidence: 82%

The role of oxidative damage in cataract etiopathogenesis

2023

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Background: Cataract usually occurs due to age and diabetes, but the mechanisms of cataract formation have not yet been fully elucidated. In this study, the relationship between cataract and oxidative stress was evaluated by examining the aqueous humor reflecting lens metabolism. Objective: In this study, the effect of oxidative stress on the etiopathogenesis of cataract was investigated through the total oxidant status (TOS), total antioxidant status (TAS), oxidative stress index (OSI), and arylesterase (ARE) levels in aqueous humor samples of patients with cataract. Design: A prospective cohort study. Methods: This study was conducted on patients who were scheduled for cataract surgery between June 2020 and March 2021. The patients were divided into four groups according to their cataract density as grades 1, 2, 3, and 4. TOS, TAS, and ARE levels of aqueous humor samples were measured spectrophotometrically, and comparisons were made between groups. Results: A total of 100 eyes of 100 patients were included in this study. TAS levels were found significantly higher in the grade 2 group compared with the grade 4 group ( p = 0.006). In addition, a significant negative correlation was present between cataract grade and TAS level ( r = −0.237; p = 0.018). There was no significant difference between diabetic and nondiabetic patients in terms of TAS, TOS, OSI, and ARE levels. Conclusion: The aqueous humor of patients with a high degree of cataract is characterized by low antioxidant capacity. Decreased antioxidant capacity has a role in cataract formation and progression.

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Antioxidant Potential of Ulexite in Zebrafish Brain: Assessment of Oxidative DNA Damage, Apoptosis, and Response of Antioxidant Defense System

Alak

Uçar

Parlak

et al. 2020

Biol Trace Elem Res

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Diyabetik ve Diyabetik Olmayan Katarakt Hastalarında Hümör Aközde ve Serumda Total Oksidatif Stres, Total Antioksidan Kapasite, Paraoksonaz, Arilesteraz ve Lipidperoksidaz Seviyelerinin Karşılaştırılması

Cited by 5 publications

References 13 publications

The Association between Diabetic Retinopathy and Levels of Ischemia-Modified Albumin, Total Thiol, Total Antioxidant Capacity, and Total Oxidative Stress in Serum and Aqueous Humor

The Association between Diabetic Retinopathy and Levels of Ischemia-Modified Albumin, Total Thiol, Total Antioxidant Capacity, and Total Oxidative Stress in Serum and Aqueous Humor

The role of oxidative damage in cataract etiopathogenesis

Antioxidant Potential of Ulexite in Zebrafish Brain: Assessment of Oxidative DNA Damage, Apoptosis, and Response of Antioxidant Defense System

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