Paraoxonase Activity in Athletic Adolescents

Çakmak, Alpay; Zeyrek, Dost; Ataş, Ali; Erel, Özcan

doi:10.1123/pes.22.1.93

Cited by 23 publications

(24 citation statements)

References 55 publications

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“…Cakmak A. et al 52) found that PON1 activities, were significantly higher in trained adolescent athletes than in controls. PON1 activities were remarkably higher in adolescents involved in wrestling (which is anaerobic in nature) at baseline than in those who were sedentary.…”

Section: Training Effects On Blood Tdpon1 Activities and Pon1p Involvmentioning

confidence: 99%

Effects of Anaerobic Training on Paraoxonase-1 Enzyme (PON1) Activities of High Density Lipoprotein Subgroups and Its Relationship with PON1-Q192R Phenotype

Turgay

Şişman

Aksu

2015

JAT

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Aim: Paraoxonase-1 (PON1) is an antiatherosclerotic enzyme located on high-density lipoprotein (HDL). The effects of anaerobic exercise on PON1 activity are unknown. Here we investigated the effects of anaerobic judo training on three different activities of same PON1 enzyme (TDPON1), including basal PON1, salt-stimulated PON1 (SPON1), and arylesterase (AE) activities, of serum, HDL, and HDL subgroups (HDLs; HDL and its subgroups) and its relationship with PON1-Q192R phenotype (PON1P). Methods: Our study included 18 Turkish national female judoists (mean age: 17.9 0.8 years). Before and after 5 months of anaerobic training, critical speed (CS), TDPON1 activities, cholesterol levels in the serum and supernatants of HDLs obtained by polyethylene glycol, and other major blood lipids and lipoproteins (BLLPs) including triglycerides were determined using blood samples taken after overnight fasting. PON1P groups (PGs) were categorized as QQ (QG; persons with low activity) and R carriers (QR RR) (RG; persons with high activity) according to SPON1/AE activity ratios. The results were considered statistically significant at P ≤ 0.05. Results: Anaerobic training resulted in significantly increased the cholesterol levels of HDLs (except HDL2-C) in all subjects, but not HDLs-C in PGs. Anaerobic training resulted in significant increases in most TDPON1 activities of serum and HDLs in all subjects and (except AE) in PGs, whereas SPON1 and HDL2 AE activities increased only in the RG, which was related to PON1P. However, PON1P was not related to other measured markers, including basal BLLP profiles. Conclusions: Anaerobic training improved most TDPON1 activities of serum and HDLs and HDLs -C levels (except HDL2-C) in all subjects, but not HDLs-C in PGs. The beneficial effects of anaerobic training on SPON1 and HDL2 AE activities were depend on PON1P. The lack of response of HDL2-C to anaerobic exercise will require further research. J Atheroscler Thromb, 2015; 22: 313-326.

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Section: Training Effects On Blood Tdpon1 Activities and Pon1p Involvmentioning

confidence: 99%

Effects of Anaerobic Training on Paraoxonase-1 Enzyme (PON1) Activities of High Density Lipoprotein Subgroups and Its Relationship with PON1-Q192R Phenotype

Turgay

Şişman

Aksu

2015

JAT

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“…Hamurcu et al 14 demonstrated higher serum PON1 activity in wrestlers than sedentary. Cakmak et al 15 found higher serum PON1 activity athletic adolescents with regular physical activity than in controls. On the other hand, a previous study reported significantly increased PON1 activity values in well-trained rugby players compared with sedentary controls 32 .…”

Section: Discussionmentioning

confidence: 99%

“…In addition, oxidative stress has been reported to affect the expression and activity of PON1 8,9 . Several studies have investigated PON1 activity in many different conditions 3,14,15 . Tomas et al 3 assessed the effects of a single bout of exercise on PON1 activity in humans.…”

Section: Discussionmentioning

confidence: 99%

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Serum paraoxonase activity and lipid hydroperoxide levels in adult football players after three days football tournament

Atli¹

2013

Afr H. Sci.

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Background: It has been suggested that physical activity is an important factor in the prevention and treatment of cardiovascular diseases. Low serum paraoxononase-1 (PON1) activity is with an associated risk of atherosclerotic disease. Objectives: In this study, we aimed to investigate serum PON1 activity and lipid hydroperoxide (LOOH) levels in adult football players after three days football tournament. Methods: Twenty-three adult male football players and 23 sedentary male subjects after three days football tournament were enrolled. Serum paraoxonase, arylesterase activities and LOOH levels were determined. Results: Serum paraoxonase and arylesterase activities were signiûcantly higher in football players than sedentary subjects (all, p<0.05), while LOOH levels were significantly lower (p< 0.05). Serum LOOH levels were inversely correlated with paraoxonase and arylesterase activities (r=-0.552, p<0.001; r=-0.812, p<0.001; respectively) in adult football players. Conclusion: Our data show, for the first time, that physical activity is associated with increased PON1 activity and decreased oxidative stress after three days football tournament. In addition, physical activity for a healthy life is important in increasing serum PON1 activity, and this may play a role in the prevention of atherosclerosis.

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“…It has been demonstrated that the plasma PON1 activity is elevated in athletic adolescents who engage in regular physical activity, and in football players three days after a tournament [7,15]. In addition, five months of anaerobic training induced an elevation in the circulating PON1 activity [83].…”

Section: Paraoxonase 1 Myeloperoxidase and Physical Activitymentioning

confidence: 99%

The contribution of paraoxonase 1 and myeloperoxidase to HDL-cholesterol functionality

Malara

Kęska

Lutosławska

2016

Biomedical Human Kinetics

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SummaryThe purpose of this study was to analyse the scientific evidence concerning the effects of two enzymes -paraoxonase 1 and myeloperoxidase -on the functions of HDL-cholesterol. It is well documented that disturbed circulating lipoproteins (a high total and high LDL-cholesterol, and low HDL-cholesterol) bring about atherosclerosis and an increased risk of cardiovascular disease (CVD) which is recognised as the main cause of death all around the world. In consequence, numerous studies have focused on procedures which will improve the plasma lipoproteins profile by decreasing the total cholesterol and the LDL-cholesterol (LDL-C) and increasing the HDL-cholesterol (HDL-C). However, the anti-atherogenic role of HDL-C has been challenged in studies showing that genetically elevated HDL-cholesterol does not offer protection against CVD. Moreover, it has been found that raising the circulating HDL-cholesterol fails to reduce atherosclerosis. The doubts concerning the protective role of HDL-C have been supported by in vitro studies which indicate that the HDL-C from patients with atherosclerosis does not have a protective action, but does stimulate inflammation and free radical synthesis. The above data suggests that HDL-C, commonly recognised as protective against atherosclerosis, in some circumstances becomes pro-atherogenic, and is thus dysfunctional. Our review focuses on two enzymes -paraoxonase 1 (PON1) and myeloperoxidase (MPO) -which markedly affect the properties of HDL-C and contribute to its anti -or pro-atherogenic activity. Moreover, the effects of the diet and physical activity on PON1 and MPO are summarised with respect to the HDL-C functionality.

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Paraoxonase Activity in Athletic Adolescents

Cited by 23 publications

References 55 publications

Effects of Anaerobic Training on Paraoxonase-1 Enzyme (PON1) Activities of High Density Lipoprotein Subgroups and Its Relationship with PON1-Q192R Phenotype

Effects of Anaerobic Training on Paraoxonase-1 Enzyme (PON1) Activities of High Density Lipoprotein Subgroups and Its Relationship with PON1-Q192R Phenotype

Serum paraoxonase activity and lipid hydroperoxide levels in adult football players after three days football tournament

The contribution of paraoxonase 1 and myeloperoxidase to HDL-cholesterol functionality

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