Paraoxonase Activity and Oxidative Status in Patients with Tinnitus

Koç, Sema; Akyüz, Servet; Somuk, Battal Tahsin; Soyalıç, Harun; Yılmaz, Burak; Taşkın, Abdullah; Bilinc, Hasan; Aksoy, Nurten

doi:10.7874/jao.2016.20.1.17

Cited by 18 publications

(27 citation statements)

References 29 publications

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“…Following noise exposure, levels of oxidative stress were significantly increased compared to normal animals, and hearing function sharply declined. A recent study showed that tinnitus patients express significantly higher total oxidant status and oxidative index levels compared to control subjects (Koç et al, 2016 ) which can possibly cause dysfunctions in the microcirculation of the inner ear (Neri et al, 2002 , 2006 ). The exact role of oxidative stress in tinnitus is still under debate.…”

Section: Discussionmentioning

confidence: 99%

A Pilot Genome-Wide Association Study Identifies Potential Metabolic Pathways Involved in Tinnitus

et al. 2017

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Tinnitus, the perception of an auditory phantom sound in the form of ringing, buzzing, roaring, or hissing in the absence of an external sound source, is perceived by ~15% of the population and 2.5% experiences a severely bothersome tinnitus. The contribution of genes on the development of tinnitus is still under debate. The current manuscript reports a pilot Genome Wide Association Study (GWAS) into tinnitus, in a small cohort of 167 independent tinnitus subjects, and 749 non-tinnitus controls, who were collected as part of a cross-sectional study. After genotyping, imputation, and quality checking, the association between the tinnitus phenotype and 4,000,000 single-nucleotide polymorphisms (SNPs) was tested followed by gene set enrichment analysis. None of the SNPs reached the threshold for genome-wide significance (p < 5.0e–8), with the most significant SNPs, situated outside coding genes, reaching a p-value of 3.4e–7. By using the Genetic Analysis of Complex Traits (GACT) software, the percentage of the variance explained by all SNPs in the GWAS was estimated to be 3.2%, indicating that additive genetic effects explain only a small fraction of the tinnitus phenotype. Despite the lack of genome-wide significant SNPs, which is, at least in part, due to the limited sample size of the current study, evidence was found for a genetic involvement in tinnitus. Gene set enrichment analysis showed several metabolic pathways to be significantly enriched with SNPs having a low p-value in the GWAS. These pathways are involved in oxidative stress, endoplasmatic reticulum (ER) stress, and serotonin reception mediated signaling. These results are a promising basis for further research into the genetic basis of tinnitus, including GWAS with larger sample sizes and considering tinnitus subtypes for which a greater genetic contribution is more likely.

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Section: Discussionmentioning

confidence: 99%

A Pilot Genome-Wide Association Study Identifies Potential Metabolic Pathways Involved in Tinnitus

et al. 2017

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“…As the oxidant molecules may affect each other, TOS measurement was developed to reflect the total antioxidant status instead of individual measurements (8)(9)(10). Some studies investigated the effects of the oxidative system and antioxidant enzyme levels on various diseases including migraine, head and neck tumors, chronic tonsillitis, nasal polyps, adenoid hypertrophy, Behçet's disease, and chronic obstructive lung disease (16)(17)(18)(19)(20)(21).…”

Section: Discussionmentioning

confidence: 99%

Serum Oxidative Stress Levels in Patients with Nasal Septal Deviation

Ekinci

Karataş

Yetiş

et al. 2017

Turk Arch Otorhinolaryngol

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Objective: Comparison of the total oxidant status (TOS), total antioxidant status (TAS) and paraoxonase (PON1) serum levels in patients with nasal septum deviation (NSD) and healthy subjects. Methods:The TAS, TOS, and PON1 serum levels of 47 patients with NSD (mean age 35.3) and 50 healthy subjects (mean age 37.8) were compared in this study. Results:We found significantly higher TAS levels in the control group (p<0.001). The mean TAS value was 1.196 mmoL/L in the control group, whereas it was 1.046 mmoL/L in the NSD group. On the other hand, TOS was significantly higher in the NSD group (p<0.001). We found that the mean TOS value was 6.600 mmoL/L in the control group, and 20.194 mmoL/L in the NSD group. The NSD and control groups had similar PON1 levels (p=0.446). The mean PON1 value was 279.64 U/L in the control group, and 324.21 U/L in the NSD group. Conclusion:We detected higher TOS and lower TAS levels in patients with NSD compared to healthy subjects. These results indicate that patients with NSD are exposed to oxidative stress.

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“…Antioxidant defense systems have been developed in aerobic organisms to control the formation of free radicals and to prevent the harmful effects of these molecules. However, in some cases, the available antioxidant defense system is missing for avoiding to the toxic effects of free radicals and a condition called oxidative stress occurs and a condition called oxidative stress occurs [8,[12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

“…Total antioxidant status (TAS), total oxidant status (TOS) and oxidative stress index (OSI) are used to defined as the oxidant/antioxidant balance. TOS, TAS, and OSI are the parameters used as oxidative stress markers [12,13]. Another important group of physiological antioxidant defense system is the group of sulfhydryl (-SH).…”

Section: Introductionmentioning

confidence: 99%

A Comprehensive Study of Oxidative Stress in Tinnitus Patients

Çelik

Koyuncu

2018

Indian J Otolaryngol Head Neck Surg

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Oxidative stress is considered to be one of the molecular changes that are the underlying causes of tinnitus. The aim of this study was to investigate the dynamic thiol/disulphide homeostasis as a new oxidative stress parameter in tinnitus patients as well as to investigate the lipid hydroperoxide (LOOH), total antioxidant status (TAS), total oxidant status (TOS) and oxidative stress index (OSI) parameters and compare the results with the results of the healthy control group. A prospective controlled trial was performed on tinnitus patients in Harran University hospital. A total of 70 subjects, including 35 tinnitus patients and 35 healthy individuals participated in this study. Their total thiol, native thiol levels and LOOH, TAS, TOS levels were measured in plasma of all tinnitus patients and healthy volunteers participants. TOS and OSI levels were significantly increased, and TAS levels were significantly lower in the patient groups compared with the control group (p \ 0.01). Native thiol levels and Native thiol/total thiol ratios were significantly lower in the tinnitus group compared to the control group (p \ 0.01). Disulphide level and disulphide/native thiol and disulphide/total thiol ratios were significantly higher in the patients (p \ 0.01). Also, LOOH ratios were significantly higher in the tinnitus group (p \ 0.01). The results of this study reveal that in tinnitus cases, the oxidative stress and antioxidant enzyme imbalance were more significant than in healthy control group. The nature of the relationship between oxidative stress and tinnitus should be clarified with larger studies.

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Paraoxonase Activity and Oxidative Status in Patients with Tinnitus

Cited by 18 publications

References 29 publications

A Pilot Genome-Wide Association Study Identifies Potential Metabolic Pathways Involved in Tinnitus

A Pilot Genome-Wide Association Study Identifies Potential Metabolic Pathways Involved in Tinnitus

Serum Oxidative Stress Levels in Patients with Nasal Septal Deviation

A Comprehensive Study of Oxidative Stress in Tinnitus Patients

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