Paraoxonase 1 decline and lipid peroxidation rise reflect a degree of brain atrophy and vascular impairment in dementia

Bednarz−Misa, Iwona; Berdowska, Izabela; Zboch, Marzena; Misiak, Błażej; Zieliński, Bogdan; Płaczkowska, Sylwia; Fleszar, Mariusz G.; Wiśniewski, Jerzy; Gamian, Andrzej; Krzystek−Korpacka, Małgorzata

doi:10.17219/acem/111377

Cited by 24 publications

(12 citation statements)

References 29 publications

(51 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

Section: Discussionmentioning

confidence: 99%

“…Some authors have concluded that the principal biochemical mechanisms involved in inducing OS in obesity are hyperleptinaemia, low antioxidant defences and chronic inflammation. [28][29][30][31] Therefore, obesity is not only characterized by an OS state, but it is also defined as a low-grade inflammatory disease. In agreement with this, together with the low values of the antioxidant enzymes PON1 and CAT, we found leptin values 4 times higher in morbidly obese patients than 1 year after BS, in addition to high CRP levels that were 5 times higher before BS.…”

Section: F I G U R Ementioning

confidence: 99%

See 1 more Smart Citation

Bariatric surgery decreases oxidative stress and protein glycosylation in patients with morbid obesity

Carmona-Maurici

Amigó

Cuello

et al. 2020

Eur J Clin Investigation

View full text Add to dashboard Cite

Background: There is growing evidence that oxidative stress (OS) is a critical factor linking obesity with its associated comorbidities, such as cardiovascular diseases. Aim: To evaluate the degree of OS in people with morbid obesity and its relationship with glycoproteins, determined using 1H-NMR spectroscopy, before and after bariatric surgery (BS). Methods: In this observational cohort study, plasma from 24 patients with BMI ≥ 40 kg/m 2 (age: 21-65 years) was used to measure metabolites implicated in OS. We measured glycoprotein (GlycA, GlycB and GlycF) areas and shape factors (H/W = height/width). Results: One year after BS, oxidized low-density lipoprotein had decreased by 49% (P < .0001), malondialdehyde by 32% (P = .0019) and lipoprotein (a) by 21% (P = .0039). The antioxidant enzymes paraoxonase-1 and catalase increased after BS (43%, P < .0001 and 54%, P = .0002, respectively). Superoxide dismutase-2 had fallen 1 year after BS (32%, P = .0052). After BS, both the glycoprotein areas and shape factors decreased by 20%-26%. These glycoproteins were significantly correlated with OS parameters. The plasma atherogenic index was 63% higher in obese individuals than 1 year after BS and correlated positively with glycoproteins. Conclusion: For the first time, we here demonstrate the relationship between OS parameters and glycoproteins in people with morbid obesity. So glycoproteins could therefore be a good indicator, together with the oxidative state to assess patient prognosis after BS.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: F I G U R Ementioning

confidence: 99%

Bariatric surgery decreases oxidative stress and protein glycosylation in patients with morbid obesity

Carmona-Maurici

Amigó

Cuello

et al. 2020

Eur J Clin Investigation

View full text Add to dashboard Cite

show abstract

“…Disulfide (µmol / l) / alb (g / l). Oxidative stress index = total oxidant status / total antioxidant status) [19][20][21][22][23][24][25][26][27]. The results of hemogram and Vitamin B12, 25 OH D levels were retrospectively taken from their files.…”

Section: Laboratory Analysismentioning

confidence: 99%

Thiol Disulfide Balance Oxidative Stress and Paraoxonase 1 Activities in Children and Adolescents Aged 6-16 Years with Specific Learning Disorders

Savaş¹,

Sayar

Kara³

2021

ELECTRON J GEN MED

View full text Add to dashboard Cite

Specific learning disorders (SLD) are some of the most common neurodevelopmental disorders. The aim of this study is to determine the potential relationship between children with SLD and zinc, copper, paraoxonase 1 (PON1), arylesterase (ARY), ischemia-modified albumin, thiol balance, oxidative stress index, total antioxidant status, total oxidant status, and routine biochemical parameters.Methods: All participants were assessed with the Kiddie Schedule for Affective Disorders and Schizophrenia for School-Age Children. Total oxidant status, total antioxidant status, thiol balance, ischemia modified albumin, paraoxonase 1 activity, arylesterase activity, zinc and copper levels were measured by the spectrophotometric methods.Results: Compared to the control, the SLD group had statistically significantly lower values for PON1 antioxidant enzyme activity (p=.045), ARY antioxidant enzyme activity (p<.001), 25 OH Vitamin D (p=.005), reduced thiol ratio (p=.028), thiol oxidation reduction ratio (p=.01), native thiols (p=.024) and significantly higher values for total oxidant status (p=.017), oxidized thiol ratio (p=.028). Conclusion:The relationship between oxidative stress and SLD diagnosis in our results will be very important if it is supported by further new studies. In this case, evaluation of vitamin D, oxidative stress, antioxidant status and thiol balance may come to the agenda in the diagnosis and treatment of SLD.

show abstract

“…The activity calculation was made by subtracting the basal PON1 activity from the stimulated PON1 activity. The results are given in U / l [10].…”

Section: Paraoxonase 1 (Pon1)mentioning

confidence: 99%

Paraoxonase 1 activity as a new biochemical marker in the diagnosis of peripheral arterial disease

Savaş¹,

Etli²

2021

Turkish Journal of Clinics and Laboratory

View full text Add to dashboard Cite

Aim: Peripheral artery disease (PAD) is an atherosclerotic disease. It is seen in older ages. It causes cardiovascular morbidity and mortality. PAD may progress without any symptoms. Despite its high frequency, there is no laboratory parameter that directly indicates peripheral arterial disease in routine biochemical tests. The relationship between oxidative stress increase and PAD is known. In this study, it is aimed to show the possible usage of the activities of the antioxidant enzymes paraoxonase 1 and arylesterase as a new marker in the diagnosis of PAD. Material and Methods:A total of 70 individuals, including 35 in the control group and 35 peripheral artery patients, were included in this study. The collected blood serums were separated and stored at -80 °C. Paraoxonase 1 and arylesterase activities were measured using the spectrophotometric method in the serum which was dissolved at room temperature.The results were subjected to statistical analysis. P <0.05 was accepted as the level of significance.Results: In the peripheral arterial disease group, the paraoxonase 1 and arylesterase activities were found to be significantly lower than those in the control group (p <0.05). In peripheral arterial disease, paraoxonase 1 and arylesterase activities were shown to decrease. Conclusion:In peripheral arterial disease, paraoxonase 1 and arylesterase activities were found to decrease significantly.The results of similar studies related to atherosclerosis in the literature were in line with our findings. It would be beneficial to support the results of this study with new studies and evaluate paraoxonase 1 and arylesterase activities in routine biochemistry laboratories for the diagnosis and follow-up of peripheral arterial disease.

show abstract

Paraoxonase 1 decline and lipid peroxidation rise reflect a degree of brain atrophy and vascular impairment in dementia

Cited by 24 publications

References 29 publications

Bariatric surgery decreases oxidative stress and protein glycosylation in patients with morbid obesity

Bariatric surgery decreases oxidative stress and protein glycosylation in patients with morbid obesity

Thiol Disulfide Balance Oxidative Stress and Paraoxonase 1 Activities in Children and Adolescents Aged 6-16 Years with Specific Learning Disorders

Paraoxonase 1 activity as a new biochemical marker in the diagnosis of peripheral arterial disease

Contact Info

Product

Resources

About