Paraoxonase-1 and Symptomatic Status in Carotid Artery Disease

Lioudaki, Stella; Verikokos, Christos; Kouraklis, Grigorios; Kontopodis, Nikolaos; Markakis, Georgios; Ioannou, Christos V.; Daskalopoulou, Aphrodite; Perrea, Despina; Klonaris, Chris

doi:10.1016/j.avsg.2019.07.020

Cited by 6 publications

(4 citation statements)

References 26 publications

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“…Previous studies have shown that FGF15 (FGF19 in human) can inhibit the expression of hepatic paraoxonase-1 (PON-1) in mice (36) and that human liver cancer cells treated with recombinant human FGF19 can inhibit the expression of PON-1 (37). PON-1 is an HDL-related hydrolase (38). Recent studies have found that PON-1 can prevent atherosclerosis through direct and indirect approaches (38)(39)(40).…”

Section: Discussionmentioning

confidence: 99%

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Fibroblast Growth Factor 19 Levels Predict Subclinical Atherosclerosis in Men With Type 2 Diabetes

Liu

Tong

et al. 2020

Front. Endocrinol.

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Objective: Fibroblast growth factor 19 (FGF19) plays an indispensable role in regulating bile acid, glucose, and lipid metabolism, and alterations of its circulating concentration is associated with the development of type 2 diabetes (T2D). Atherosclerosis is directly related to the death-deriving diabetic macroangiopathy in T2D, yet relationships between FGF19 and atherosclerosis in T2D remain unclear. The aim of this study was to investigate the association of circulating FGF19 levels with the development of subclinical atherosclerosis (subAS) in patients with T2D in a 3-year prospective study.Methods: In the present study, 153 newly diagnosed T2D patients without subAS were recruited at baseline, and 137 of them completed a 3-year follow-up. FGF19 levels were measured in fasting serum samples collected at baseline and the third-year visits. Carotid, femoral, and iliac intima-media thickness (IMT) were detected by high-resolution B-mode ultrasound to determine the presence of subAS. Logistic regression analysis was applied to assess the relationship between serum FGF19 and subAS in patients with T2D.Results: At baseline, serum FGF19 levels were positively correlated with carotid IMT and iliac IMT in men (r = 0.239, P = 0.036; r = 0.309, P = 0.006). At the 3-year follow-up, 25 out of 153 patients developed subAS, and FGF19 levels in men were higher in the subAS group than in the non-subAS group [202.7 (177.9-373.6) vs. 133.4 (85.6-171.3) pg/ml, P = 0.028]. Furthermore, in men, higher baseline levels of FGF19 were independently associated with a greater risk of subAS at year 3 in patients with T2D with an odds ratio (OR) of 4.798 per 1 standard deviation (SD) of the FGF19 concentration [OR = 4.798 (95% CI, 1.680-13.706), P = 0.003]. Baseline FGF19 levels yielded an area under the receiver operating characteristic curve of 0.769 to predict the development of subAS at year 3 in men with T2D.Conclusions: Serum FGF19 levels could help in predicting the development of atherosclerosis in men with T2D.

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Section: Discussionmentioning

confidence: 99%

“…PON-1 is an HDL-related hydrolase (38). Recent studies have found that PON-1 can prevent atherosclerosis through direct and indirect approaches (38)(39)(40). Therefore, FGF19 may promote atherosclerosis by inhibiting the protective effect of PON-1.…”

Section: Discussionmentioning

confidence: 99%

Fibroblast Growth Factor 19 Levels Predict Subclinical Atherosclerosis in Men With Type 2 Diabetes

Liu

Tong

et al. 2020

Front. Endocrinol.

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“…Still, the levels were not associated with cholesterol or triglyceride levels, which can be explained because complicated plaques contained more oxidized LDL, and symptomatic patients were older. It is known that PON1 levels are reduced with aging [ 55 ]. A recent study on patients with non-ST-segment elevation myocardial infarction showed that diminished PON1 levels were found in those who had an increased risk of death [ 56 ].…”

Section: Paraoxonase 1 and Its Implications In Various Diseasesmentioning

confidence: 99%

The Role of Polyphenols in Modulating PON1 Activity Regarding Endothelial Dysfunction and Atherosclerosis

Sirca,

Mureșan,

Pallag

et al. 2024

IJMS

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The incidence and prevalence of cardiovascular diseases are still rising. The principal mechanism that drives them is atherosclerosis, an affection given by dyslipidemia and a pro-inflammatory state. Paraoxonase enzymes have a protective role due to their ability to contribute to antioxidant and anti-inflammatory pathways, especially paraoxonase 1 (PON1). PON1 binds with HDL (high-density lipoprotein), and high serum levels lead to a protective state against dyslipidemia, cardiovascular diseases, diabetes, stroke, nonalcoholic fatty liver disease, and many others. Modulating PON1 expression might be a treatment objective with significant results in limiting the prevalence of atherosclerosis. Lifestyle including diet and exercise can raise its levels, and some beneficial plants have been found to influence PON1 levels; therefore, more studies on herbal components are needed. Our purpose is to highlight the principal roles of Praoxonase 1, its implications in dyslipidemia, cardiovascular diseases, stroke, and other diseases, and to emphasize plants that can modulate PON1 expression, targeting the potential of some flavonoids that could be introduced as supplements in our diet and to validate the hypothesis that flavonoids have any effects regarding PON1 function.

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“…Hence, it is hypothesized that PON1 plays a protective role in atherosclerotic disease, with reduced levels demonstrating higher atherosclerotic events [ 110 ]. In a group of 74 patients with CAS (of which 43 were asymptomatic), PON1 activity was significantly lower in the symptomatic group than the asymptomatic group (4.6 ± 1.36 versus 5.3 ± 1.19 ng/mL, respectively, p = 0.025) with an AUC of 0.654 [ 18 ].…”

Section: Protein Categorizationmentioning

confidence: 99%

Current Biomarkers for Carotid Artery Stenosis: A Comprehensive Review of the Literature

et al. 2023

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Carotid artery stenosis (CAS), an atherosclerotic disease of the carotid artery, is one of the leading causes of transient ischemic attacks (TIA) and cerebrovascular attacks (CVA). The atherogenic process of CAS affects a wide range of physiological processes, such as inflammation, endothelial cell function, smooth muscle cell migration and many more. The current gold-standard test for CAS is Doppler ultrasound; however, there is yet to be determined a strong, clinically validated biomarker in the blood that can diagnose patients with CAS and/or predict adverse outcomes in such patients. In this comprehensive literature review, we evaluated all of the current research on plasma and serum proteins that are current contenders for biomarkers for CAS. In this literature review, 36 proteins found as potential biomarkers for CAS were categorized in to the following nine categories based on protein function: (1) Inflammation and Immunity, (2) Lipid Metabolism, (3) Haemostasis, (4) Cardiovascular Markers, (5) Markers of Kidney Function, (6) Bone Health, (7) Cellular Structure, (8) Growth Factors, and (9) Hormones. This literature review is the most up-to-date and current comprehensive review of research on biomarkers of CAS, and the only review that demonstrated the several pathways that contribute to the initiation and progression of the disease. With this review, future studies can determine if any new markers, or a panel of the proteins explored in this study, may be contenders as diagnostic or prognostic markers for CAS.

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Paraoxonase-1 and Symptomatic Status in Carotid Artery Disease

Cited by 6 publications

References 26 publications

Fibroblast Growth Factor 19 Levels Predict Subclinical Atherosclerosis in Men With Type 2 Diabetes

Fibroblast Growth Factor 19 Levels Predict Subclinical Atherosclerosis in Men With Type 2 Diabetes

The Role of Polyphenols in Modulating PON1 Activity Regarding Endothelial Dysfunction and Atherosclerosis

Current Biomarkers for Carotid Artery Stenosis: A Comprehensive Review of the Literature

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