Paraoxonase-1 activity in patients with hyperemesis gravidarum

Verit, Fatma Ferda; Erel, Özcan; Çelik, Hakim

doi:10.1179/135100008x259259

Cited by 18 publications

(22 citation statements)

References 35 publications

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“…Based on their results, Engin-Ustun et al concluded that the presence of increased CRP levels in women with HG could contribute to the pathophysiological mechanism of HG, thus showing signs of the inflammatory process were present. Their finding was supported by study of Verit et al (21). Another study has shown that interleukin-6 (IL-6), which is a cytokine produced primarily by activated monocyte/macrophages and T lymphocytes and involved in inflammation and immune responses, levels are increased in pregnant women with HG in the first trimester (20).…”

Section: Discussionsupporting

confidence: 73%

“…Studies have shown that NLR, PLR, and RDW values are highly associated with the prognosis of diseases related to inflammation (16)(17)(18)(19). The studies investigating the relationship between inflammation and HG are primarily focused on the inflammatory markers in the first trimester as HG predominantly occurs in this period (20,21). However, it is unclear whether the high inflammatory markers in patients with HG cause the disease or they are the product of HG.…”

Section: Introductionmentioning

confidence: 99%

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The Existence of Continuous Systemic Inflammation in Pregnant Women with Hyperemesis Gravidarum

Yıldırım¹,

Çendek²,

Desdicioğlu³

et al. 2017

Cyprus J Med Sci

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BACKGROUNDTo evaluate the serum inflammatory markers in the first trimester in which hyperemesis gravidarum (HG) usually occurs and in the late second trimester when symptoms of HG usually resolve. MATERIALS and METHODSThe study population consisted of 170 pregnant women with HG and 185 healthy gestational-age-matched controls. White blood cell count (WBC), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and red blood cell distribution width (RDW) were compared during the first and the late second trimester. RESULTS In INTRODUCTIONNausea and vomiting are the most common complaints of pregnant women in the first trimester, affecting 70%-80% of all pregnancies (1). These mild symptoms are usually described as morning sickness (2) because nausea and vomiting typically occur in the morning and resolve during the day time. Hyperemesis gravidarum (HG) is a severe form of nausea and vomiting during pregnancy (3) that leads to weight loss, dehydration, electrolyte and acid-base imbalances, ketonuria, and nutritional deficiency (4). It affects 0.8%-3.2% of pregnant women (5, 6).

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Section: Discussionsupporting

confidence: 73%

Section: Introductionmentioning

confidence: 99%

The Existence of Continuous Systemic Inflammation in Pregnant Women with Hyperemesis Gravidarum

Yıldırım¹,

Çendek²,

Desdicioğlu³

et al. 2017

Cyprus J Med Sci

View full text Add to dashboard Cite

show abstract

“…A Danish study found a statistically significant association between HG and autoimmune diseases in general and in particular between HG and Sjögren's syndrome, Graves’ disease, rheumatoid arthritis, pernicious anaemia, coeliac disease, Crohn's disease, ulcerative colitis and psoriasis 23. Previous research has also found increased inflammatory markers in women with HG compared with healthy pregnancies 46, 47, 48, 49. Given that several of these conditions associated with HG also are associated with increased risk of CVD, we explored whether HG and CVD‐related mortality might be related.…”

Section: Discussionmentioning

confidence: 99%

Hyperemesis gravidarum and long‐term mortality: a population‐based cohort study

Fossum

Vikanes

Næss

et al. 2016

BJOG

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ObjectiveTo investigate whether exposure to hyperemesis gravidarum (HG) is associated with increased maternal long‐term mortality.DesignPopulation‐based cohort study.SettingMedical Birth Registry of Norway (1967–2002) linked to the Cause of Death Registry.PopulationWomen in Norway with singleton births in the period 1967–2002, with and without HG. Women were followed until 2009 or death.MethodsCox proportional hazard regression model was applied to estimate hazard ratios (HRs) with 95% confidence interval (CI).Main outcome measuresThe primary outcome was all‐cause mortality during follow up. Secondary outcomes were cause‐specific mortality (cardiovascular mortality, deaths due to cancer, external causes or mental and behavioural disorders).ResultsOf 999 161 women with singleton births, 13 397 (1.3%) experienced HG. During a median follow up of 26 years (25 902 036 person‐years), 43 470 women died (4.4%). Women exposed to HG had a lower risk of long‐term all‐cause mortality compared with women without HG (crude HR 0.82; 95% CI 0.75–0.90). When adjusting for confounders, this reduction was no longer significant (adjusted HR 0.92; 95% CI 0.84–1.01). Women exposed to HG had a similar risk of cardiovascular death as women not exposed (adjusted HR 1.04; 95% CI 0.83–1.29), but a lower long‐term risk of death from cancer (adjusted HR 0.86; 95% CI 0.75–0.98).ConclusionIn this large population‐based cohort study, HG was not associated with an increased risk of long‐term all‐cause mortality. Women exposed to HG had no increase in mortality due to cardiovascular disease, but had a reduced risk of death from cancer.Tweetable abstractPopulation‐based cohort study: Hyperemesis was not associated with an increased risk of long‐term mortality.

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“…Low levels of high-density lipoprotein (HDL) has been received in HG. 15,16 Thus, Paraoxonase-1 which is a HDLassociated antioxidant enzyme was found low in patients with HG. 15,16 Otherwise lipid peroxidation markers, such as malondialdehyde and lipid hydroperoxide levels, were obtained high in HG.…”

Section: Introductionmentioning

confidence: 96%

“…15,16 Thus, Paraoxonase-1 which is a HDLassociated antioxidant enzyme was found low in patients with HG. 15,16 Otherwise lipid peroxidation markers, such as malondialdehyde and lipid hydroperoxide levels, were obtained high in HG. 13,16 Protein oxidation by the reactive derivatives leads to nitration of aromatic amino acids, oxidation of thiol groups and formation of advanced oxidation protein products and transformation of some amino-acid residues to the carbonyl derivatives.…”

Section: Introductionmentioning

confidence: 96%