Dynamic thiol-disulfide homeostasis in hyperemesis gravidarum

Ergin, Merve; Çendek, Büşra Demir; Neşeli̇oğlu, Salim; Avşar, Ayşe Filiz; Erel, Özcan

doi:10.1038/jp.2015.81

Cited by 40 publications

(25 citation statements)

References 45 publications

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“…Knowing the function of thiols involved in the antioxidant system is therefore becoming increasingly important in terms of understanding several diseases associated with oxidative stress, including COPD [19]. Studies investigating the relation between oxidative stress and TDH have shown that such homeostasis is impaired in oxidative terms in patients with acute myocardial infarction, migraine, alopecia or chronic urticaria, in pregnant women with hyperemesis gravidarum (compared to normal gravidas), and in workers exposed to polycyclic aromatic hydrocarbons [14][15][16][33][34][35]. Babaoglu et al [36] assumed the presence of oxidative stress in COPD and investigated TDH in other subgroup diseases causing lower airway obstruction, such as asthma and asthma-COPD overlap syndrome (ACOS).…”

Section: Discussionmentioning

confidence: 99%

Significance of thiol/disulphide homeostasis and ischemia modified albumin levels in chronic obstructive pulmonary disease

Eroğlu

Badem

Baççıoğlu

et al. 2019

The European Research Journal

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Objectives: The severity of inflammation occurring during chronic obstructive pulmonary disease (COPD) is closely associated with oxidative stress. The aim of this study was to investigate the diagnostic value of Thiol/disulphide homeostasis (TDH) and ischemia modified albumin (IMA) levels in evaluating oxidative stress in COPD patients. Methods: This prospective study was performed with COPD patients presenting to the Kırıkkale University Hospital and with healthy volunteers. Subjects' demographic data (age, sex, body mass index, and smoking status), native thiol (NT), total thiol (TT), disulphide (Ds), IMA levels and Ds/NT, Ds/TT and NT/TT ratios were recorded. Statistical analysis was performed with SPSS 21.0 software. Results: One hundred ninety subjects were enrolled in the study, 141 COPD patients and 49 healthy volunteers. No difference was determined between the patient and control groups in terms of age, sex or body mass index. The antioxidant markers; NT and TT levels and NT/TT ratio were significantly lower in the patient group compared to the control group (p < 0.001, p < 0.001, and p < 0.003, respectively). The oxidant markers; IMA levels and Ds/NT and Ds/TT ratios were significantly higher in the patient group (p = 0.006, p = 0.003, and p = 0.003, respectively). Significant negative correlation was determined between antioxidant and oxidant parameters. Sensitivity values were NT: 87.2%, TT: 83.3%, Ds/NT ratio: 68.1%, Ds/TT ratio: 68.1%, and IMA: 77.8%. Conclusions: TDH was impaired in favor oxidants in COPD patients. TDH parameters and IMA can be used to monitor oxidative stress emerging in COPD.

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Section: Discussionmentioning

confidence: 99%

Significance of thiol/disulphide homeostasis and ischemia modified albumin levels in chronic obstructive pulmonary disease

Eroğlu

Badem

Baççıoğlu

et al. 2019

The European Research Journal

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“…The thiol-disulfide balance is a significant member of various processes consisting of antioxidant defense, immune response, modulation of enzyme activity, and apoptosis (26). Dynamic thiol-disulfide homeostasis is implicated in several disorders (27,28). For example, it has been demonstrated that impaired thiol-disulfide balance has been involved in a variety of diseases such as myocardial infarction, preeclampsia, polycystic ovary syndrome, diabetes mellitus, and cancer (29).…”

Section: Discussionmentioning

confidence: 99%

Impaired Thiol-Disulfide Balance in Acute Brucellosis

et al. 2017

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“…Due to this carnage, there is correlation between the degree of ketonuria and HG [17]. While there is a negative correlation between disease severity and native thiol and total thiol, a positive correlation is detected between disulfide [18]. The American College of Obstetricians and Gynecologists (ACOG) currently recommends that a combination of oral pyridoxine hydrochloride (vitamin B6) and doxylamine succinate be used as first-line treatment for nausea and/or vomiting during pregnancy if pyridoxine monotherapy does not relieve symptoms [19].…”

Section: Discussionmentioning

confidence: 99%

The thiol/disulfide balance in ketone positive and ketone negative pregnant women with nausea and vomiting — a prospective study in a tertiary center

et al. 2020

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Objectives:We aimed to investigate the thiol/disulfide balance in ketone positive (hyperemesis gravidarum) and ketone negative pregnant women with nausea and vomiting. Material and methods:A total of 60 patients under the 14 th week of pregnancy were included in this study, and they were divided into two groups. Group 1 included 30 pregnant women with ketone positive, group 2 included 30 ketone negative pregnant women with nausea, and vomiting. Results:The native thiol, disulfide, and total thiol concentrations were measured using an automated method and compared among the two groups. There were also three indexes that are derived from disulfide, native and total thiol (Index 1 = 100 × disulfide/native thiol); (Index 2 = 100 × disulfide/total thiol); (Index 3 = 100 × native thiol/total thiol). When compared with Group 1 and Group 2, total thiol was high, native thiol was low but not statistically significant. Disulphide (p = 0.046), index 1 (p = 0.036) and index 3 (p = 0.034) were statistically significant. Conclusions:Patients with ketone positive are shifting to OS direction due to lack of nutrients and electrolytes. This study emphasizes the therapeutic potential of antioxidant supplementation, which is becoming an increasingly used approach in treating the symptoms of women with ketone positive.

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Dynamic thiol-disulfide homeostasis in hyperemesis gravidarum

Cited by 40 publications

References 45 publications

Significance of thiol/disulphide homeostasis and ischemia modified albumin levels in chronic obstructive pulmonary disease

Significance of thiol/disulphide homeostasis and ischemia modified albumin levels in chronic obstructive pulmonary disease

Impaired Thiol-Disulfide Balance in Acute Brucellosis

The thiol/disulfide balance in ketone positive and ketone negative pregnant women with nausea and vomiting — a prospective study in a tertiary center

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