Paraoxonase-1 activities in children and adolescents with type 1 diabetes mellitus

Craciun, Cristina; Leucuţa, Daniel; Rusu, Razvan; David, Bianca; Creţ, Victoria; Dronca, Eleonora

doi:10.18388/abp.2015_1209

Cited by 18 publications

(23 citation statements)

References 29 publications

(32 reference statements)

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“…Two studies used the same case series, respectively, so the most recent publication was included . Lastly, 36 case‐control studies were included in the meta‐analyses . Thirty‐four publications were written in English, and two were written in Chinese .…”

Section: Resultsmentioning

confidence: 99%

“…As shown in Table , thirty‐four articles studied the association between paraoxonase 1 activity and risk of DM included 3474 DM patients and 3246 controls. Twenty‐one studies were performed in Asian countries, and other thirteen in non‐Asian . Twenty‐three articles were focused on T2DM, one on T1DM and T2DM, four on TDM, two on GDM or one on NIDDM, and three were unknown.…”

Section: Resultsmentioning

confidence: 99%

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The association between paraoxonase 1 activity and the susceptibilities of diabetes mellitus, diabetic macroangiopathy and diabetic microangiopathy

Zhong

2018

J Cellular Molecular Medi

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We carried out this meta‐analysis to explore the influence of paraoxonase 1 activity on the susceptibility of diabetes mellitus (DM), diabetic macroangiopathy and diabetic microangiopathy. Relevant studies were identified from PubMed, Web of Science and CNKI without language limitation, following the inclusion and exclusion criteria. Statistical analyses were implemented with the STATA 12.0 statistical software. Thirty‐six case‐control studies were included in the meta‐analyses, in which 35 for the association between paraoxonase 1 activity and DM risk, 8 for diabetic macroangiopathy and 7 for diabetic microangiopathy. Paraoxonase 1 activity was significantly associated with the susceptibility of DM in pooled population (SMD = −1.37, 95% CI = −1.79 ∼ −0.96, P = .000), and Asians (SMD = −2.00, 95% CI = −2.56 ∼ −1.44, P = .000), but not in non‐Asians (SMD = −0.44, 95% CI = −0.91 ∼ 0.03, P = .069). However, marked heterogeneity was existed (I2 = 98.10%, P = .000) and subgroup analyses failed to investigate the sources of heterogeneity. Then, meta‐regression was performed and found that ethnicity could explain the observed between‐study heterogeneity (P = .002). Meanwhile, significant associations were found between paraoxonase 1 activity and diabetic macroangiopathy (SMD = −1.06, 95% CI = −1.63 ∼ −0.48, P = .000) and diabetic microangiopathy (SMD = −0.72, 95% CI = −1.32 ∼ −0.13, P = .018). In conclusion, paraoxonase 1 activity plays important roles in the risk of DM, diabetic macroangiopathy and microangiopathy with ethnicity differences. Further studies with large sample and well design are needed to confirm these results.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

The association between paraoxonase 1 activity and the susceptibilities of diabetes mellitus, diabetic macroangiopathy and diabetic microangiopathy

Zhong

2018

J Cellular Molecular Medi

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“…In our patients with AP, improvement in blood biochemistry after the start of treatment was remarkable, and it was in parallel with the rise in SOD and TAC levels which are the components of antioxidant defense system. PON-1 is an HDL-C-associated antioxidant enzyme that inhibits LDL-C oxidation in human serum [12,14]. It confers protection against free radicals by limiting the oxidation of phospholipids and is known to lose its activity in the oxidative environment.…”

Section: Discussionmentioning

confidence: 99%

“…When CTSI scores were evaluated, it was seen that majority of our patients had mild AP (0-3 points, n = 18, 72%), followed by moderate (4-6 points, n = 6, 24%) and severe (7-10 points, n = 1, 4%). Average length of hospital stay was 6 days (range, [3][4][5][6][7][8][9][10][11][12][13][14] and there was no mortality.…”

Section: Assessment Of Disease Severity (Scoring)mentioning

confidence: 96%

“…However, cumulative data including our previous studies suggest that oxidative stress plays the major role [8][9][10]. It has also been shown that impaired lipid metabolism plays an important role in the pathogenesis of numerous diseases, including cardiovascular conditions, infectious diseases, diabetes, carcinoma and many inflammatory diseases including acute pancreatitis [8,11,12].…”

Section: Introductionmentioning

confidence: 97%

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Serum paraoxonase (a high-density lipoprotein-associated lipophilic antioxidant) activity in clinical follow-up of patients with acute pancreatitis, with particular emphasis on oxidative stress parameters and lipid profile: a prospective pilot trial

Yuksekdag

Yüksel

Topcu

et al. 2019

Libyan Journal of Medicine

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Lyso‐DGTS lipid isolated from microalgae enhances PON1 activities in vitro and in vivo, increases PON1 penetration into macrophages and decreases cellular lipid accumulation

et al. 2018

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High-density lipoprotein (HDL) plays an important role in preventing atherosclerosis. The antioxidant effect of HDL is mostly associated with paraoxonase 1 (PON1) activity. Increasing PON1 activity using nutrients might improve HDL function and quality and thus, decrease atherosclerotic risk. We previously isolated and identified a novel active compound, lyso-DGTS (C20:5,0) from Nannochloropsis sp. ethanol extract. In the present study, its effect on PON1 activities was examined and the mechanism by which the compound affects PON1 activity was explored. Lyso-DGTS elevated recombinant PON1 (rePON1) lactonase and esterase activities in a dose- and time-responsive manner, and further stabilized and preserved rePON1 lactonase activity. Incubation of lyso-DGTS with human serum for 4 h at 37 °C also increased PON1 lactonase activity in a dose-responsive manner. Using tryptophan-fluorescence-quenching assay, lyso-DGTS was found to interact with rePON1 spontaneously with negative free energy (ΔG = -22.87 kJ mol at 25 °C). Thermodynamic parameters and molecular modeling calculations showed that the main interaction of lyso-DGTS with the enzyme is through a hydrogen bond with supporting van der Waals interactions. Furthermore, lyso-DGTS significantly increased rePON1 influx into macrophages and prevented lipid accumulation in macrophages stimulated with oxidized low-density lipid dose-dependently. In vivo supplementation of lyso-DGTS to the circulation of mice fed a high-fat diet via osmotic mini-pumps implanted subcutaneously significantly increased serum PON1 lactonase activity and decreased serum glucose concentrations to the level of mice fed a normal diet. Our findings suggest a beneficial effect of lyso-DGTS on increasing PON1 activity and thus, improving HDL quality and atherosclerotic risk factors. © 2018 BioFactors, 44(3):299-310, 2018.

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Paraoxonase-1 activities in children and adolescents with type 1 diabetes mellitus

Cited by 18 publications

References 29 publications

The association between paraoxonase 1 activity and the susceptibilities of diabetes mellitus, diabetic macroangiopathy and diabetic microangiopathy

The association between paraoxonase 1 activity and the susceptibilities of diabetes mellitus, diabetic macroangiopathy and diabetic microangiopathy

Serum paraoxonase (a high-density lipoprotein-associated lipophilic antioxidant) activity in clinical follow-up of patients with acute pancreatitis, with particular emphasis on oxidative stress parameters and lipid profile: a prospective pilot trial

Lyso‐DGTS lipid isolated from microalgae enhances PON1 activities in vitro and in vivo, increases PON1 penetration into macrophages and decreases cellular lipid accumulation

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