Paraneoplastic takotsubo syndrome with ventricular thrombus and stroke

Finsterer, Josef; Stöllberger, Claudia; Pulgram, T

doi:10.1007/s00059-013-3956-2

Cited by 6 publications

(2 citation statements)

References 21 publications

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“…Another interesting finding was the development of LV thrombus. There have been some reports of TTC complicated with thrombus 6 , 7 , 8 , 9 , 10 , 11 . The clinical importance of this thrombus is that it may be a potential source of embolic events 12 .…”

Section: Discussionmentioning

confidence: 99%

Takotsubo Cardiomyopathy Caused by Pulmonary Tuberculosis: A Case Report

Lee

Park

et al. 2014

Tuberc Respir Dis

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Takotsubo cardiomyopathy (TTC) is defined as a reversible, acute ventricular dysfunction without any evidence of coronary artery obstruction. There have been reports of TTC caused by emotional or physical stress, drug use, hormone imbalance, or medical conditions such as pulmonary disease, sepsis, and trauma, but a relationship between TTC and pulmonary tuberculosis has not previously been reported. From our knowledge, this is the first report of TTC caused by pulmonary tuberculosis.

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Section: Discussionmentioning

confidence: 99%

Takotsubo Cardiomyopathy Caused by Pulmonary Tuberculosis: A Case Report

Lee

Park

et al. 2014

Tuberc Respir Dis

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“…The diagnosis of cancer at the TTS event or during follow-up was predictive for a higher rate of the composite endpoint, indicating that the prevalence of cancer is high in TTS patients and is a risk factor for worse outcomes [35]. In cancer patients, the emotional stress of receiving a cancer diagnosis, paraneoplastic syndrome, pain syndromes, surgical treatment or chemotherapy may lead to TTS [167][168][169][170][171]. A neoplastic marker, carbohydrate antigen (CA)-125, may be useful for the early risk stratification of TTS subjects, because CA-125 may reflect the inflammatory state, prediction of the hospital stay duration, incidence of adverse events at follow-up and general clinical conditions in patients with TTS [172].…”

Section: Cancermentioning

confidence: 99%

Takotsubo Syndrome: Translational Implications and Pathomechanisms

Fan

Yang

Kowitz

et al. 2022

IJMS

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Takotsubo syndrome (TTS) is identified as an acute severe ventricular systolic dysfunction, which is usually characterized by reversible and transient akinesia of walls of the ventricle in the absence of a significant obstructive coronary artery disease (CAD). Patients present with chest pain, ST-segment elevation or ischemia signs on ECG and increased troponin, similar to myocardial infarction. Currently, the known mechanisms associated with the development of TTS include elevated levels of circulating plasma catecholamines and their metabolites, coronary microvascular dysfunction, sympathetic hyperexcitability, inflammation, estrogen deficiency, spasm of the epicardial coronary vessels, genetic predisposition and thyroidal dysfunction. However, the real etiologic link remains unclear and seems to be multifactorial. Currently, the elusive pathogenesis of TTS and the lack of optimal treatment leads to the necessity of the application of experimental models or platforms for studying TTS. Excessive catecholamines can cause weakened ventricular wall motion at the apex and increased basal motion due to the apicobasal adrenoceptor gradient. The use of beta-blockers does not seem to impact the outcome of TTS patients, suggesting that signaling other than the beta-adrenoceptor-associated pathway is also involved and that the pathogenesis may be more complex than it was expected. Herein, we review the pathophysiological mechanisms related to TTS; preclinical TTS models and platforms such as animal models, human-induced pluripotent stem cell-derived cardiomyocyte (hiPSC-CM) models and their usefulness for TTS studies, including exploring and improving the understanding of the pathomechanism of the disease. This might be helpful to provide novel insights on the exact pathophysiological mechanisms and may offer more information for experimental and clinical research on TTS.

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Chemotherapy-Induced Takotsubo Syndrome

Budnik

Kucharz

Wiechno

et al. 2018

Advances in Experimental Medicine and Biology

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Cardiovascular complications are a significant problem in systemically treated cancer patients. One such complication is Takotsubo cardiomyopathy, also known as Takotsubo syndrome. It is most frequently defined as a sudden and transient left or right ventricular systolic dysfunction; mimicking acute coronary syndrome, but without the associated changes in coronary arteries. Takotsubo syndrome is a relatively little known complication that appears in the course of oncological treatment, and its incidence has not yet been established. In this study, we reviewed Medline database according to case reports concerning takotsubo syndrome appearing after systemic treatment in oncological patients. We took into consideration all types of anticancer drugs. We reviewed the changes reported in the electrocardiography, echocardiography, and coronary angiography, and also the level of troponin, a marker of acute coronary syndrome elevation. In view of the increasing frequency of cardiac complications reported in patients receiving systemic oncological treatment, Takotsubo syndrome appears to be underdiagnosed. However, the syndrome may be linked to potentially fatal complications such as cardiogenic shock or cardiac arrest. Therefore, it seems essential to carry out appropriate diagnostic procedures for every patient experiencing clinical side effects of onco-pharmacotherapy. In patients with chest pain and dyspnea during or after treatment, Takotsubo syndrome should be considered, particularly that the syndrome requires a different therapy approach than that used in a coronary syndrome. Diagnostic procedures should include echocardiogram and the assessment of myocardial necrosis markers and natriuretic peptides.

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Paraneoplastic takotsubo syndrome with ventricular thrombus and stroke

Cited by 6 publications

References 21 publications

Takotsubo Cardiomyopathy Caused by Pulmonary Tuberculosis: A Case Report

Takotsubo Cardiomyopathy Caused by Pulmonary Tuberculosis: A Case Report

Takotsubo Syndrome: Translational Implications and Pathomechanisms

Chemotherapy-Induced Takotsubo Syndrome

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