Paraneoplastic syndromes of gynecologic neoplasms.

Ashour, Ahmed; Verschraegen, Claire F.; Kudelka, Andrzej P.; Kavanagh, John J.

doi:10.1200/jco.1997.15.3.1272

Cited by 46 publications

(41 citation statements)

References 89 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Moreover, the syndrome has been reported in cases of neoplasias of the breast, the lung and the urinary tract [1,6]. However, manifestations of the Leser-Trélat sign in gynaecologic malignancies and in particular in cases of ovarian cancer, as in our patient, are rare [3,7]. …”

Section: Case Presentationmentioning

confidence: 58%

Leser-Trélat sign presenting in a patient with ovarian cancer: a case report

et al. 2009

View full text Add to dashboard Cite

IntroductionSeborrheic keratoses are very common findings in elderly patients. However, a sudden onset and dramatic increase in the number and size of these benign lesions deserves special attention, since this may represent the Leser Trélat sign, a rare paraneoplastic cutaneous syndrome.Case presentationA 92-year-old female presented to our clinic with multiple eruptive seborrheic keratoses, which had dramatically increased in size and number over the past two years. A diagnostic work-up revealed an ovarian carcinoma. Hence, cutaneous findings in our patient were consistent with the diagnosis of the Leser-Trélat sign.ConclusionThe Leser-Trélat sign may coincide with the diagnosis of occult cancer or follow or precede it by months or years. Practitioners should take cases of eruptive seborrheic keratoses seriously and perform thorough patient examinations.

show abstract

Section: Case Presentationmentioning

confidence: 58%

Leser-Trélat sign presenting in a patient with ovarian cancer: a case report

et al. 2009

View full text Add to dashboard Cite

show abstract

“…The pathogenesis of DIC associated with malignancies is hypothesized that patients with cancer may have increased production of procoagulants or a direct release of tissue factor by the neoplastic cells. In addition, DIC that appears with a malignancy is usually subclinical and may be exacerbated by antitumor chemotherapy, major surgery, infection, cerebral infarction, or massive transfusion [1]. In our patient, intratumoral massive bleeding was thought to lead to overt DIC, which is an extremely rare condition.…”

Section: Resultsmentioning

confidence: 84%

“…Chronic disseminated intravascular coagulation (DIC) is often found in patients with advanced gynecologic malignancies. However, acute DIC is rare in cancer patients [1]. We report here a case of stage IIIc ovarian carcinoma which presented with DIC associated with a massive intratumoral hemorrhage.…”

Section: Introductionmentioning

confidence: 97%

Disseminated Intravascular Coagulation Associated with Intratumoral Hemorrhage of Ovarian Cancer

Matsushita

Kurabayashi²,

Tomita³

et al. 2001

Gynecol Obstet Invest

View full text Add to dashboard Cite

Background: Ovarian carcinoma usually presents in an indolent manner. A patient with ovarian cancer rarely shows acute clinical features which require immediate medical intervention. Case: We present a 36-year-old Japanese woman with an ovarian tumor, who suffered general fatigue and increased abdominal girth on admission. Her hemoglobin, platelet count and fibrinogen were decreased, and fibrin/fibrinogen degradation products were elevated, which determined the diagnosis of disseminated intravascular coagulation (DIC). Since computed tomography scan and magnetic resonance imaging revealed an intratumoral hemorrhage, an emergency laparotomy was performed. The patient was found to have ovarian cancer with a massive intratumoral hemorrhage, and DIC improved immediately after the operation. Conclusion: The clinician should be alert to the possibility that intratumoral bleeding of ovarian cancer might be associated with DIC.

show abstract

“…Las glomerulopatías paraneoplásicas (GPNP) son originadas por productos de las células tumorales: hormonas, factores de crecimiento, citoquinas o antígenos tumorales 1,11 .…”

Section: Discussionunclassified

“…Con menor frecuencia: renales, prostáticos, colorrectales, mamarios, pancreáticos, tímicos, etc 12,13 . Es extremadamente raro que un SN se asocie a tumores ginecológicos 1,11,12,14 . En estas 2 pacientes el tumor fue un carcinoma invasor de células escamosas del cuello uterino.…”

Section: Discussionunclassified