Disseminated Intravascular Coagulation Associated with Intratumoral Hemorrhage of Ovarian Cancer

Matsushita, Hiroshi; Kurabayashi, Takumi; Tomita, Masatoshi; Yamamoto, Yasuaki; Aoki, Yoichi; Tanaka, Kenichi

doi:10.1159/000058064

Cited by 7 publications

(2 citation statements)

References 7 publications

(11 reference statements)

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“…Generally, pancreas, brain, lung, and ovarian cancers have been associated with the higher risks of developing venous thrombosis [12]. In addition, the presence of disseminated intravascular coagulation in patients with ovarian cancer may indicate a hypercoagulative status [13]. One direct evidence for the hypercoagulative state is the frequently overexpressed tissue factor in ovarian cancer tissue, which could activate the extrinsic coagulation cascade and cause thrombolic events in ovarian cancer patients [14].…”

Section: Discussionmentioning

confidence: 99%

Risk of ischemic stroke in patients with ovarian cancer: a nationwide population-based study

Kuan

Teng

et al. 2014

BMC Med

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BackgroundCancer patients are at risk of thromboembolism. However, studies investigating the relationship between ovarian cancer and ischemic stroke are lacking. The objectives of this study were to assess the association between ovarian cancer and ischemic stroke, and to determine the predictive risk factors.MethodsOvarian cancer patients aged 20 years and older without antecedent cerebrovascular events and who were followed up for more than 1 year between 1 January 2003 and 31 December 2011 were recruited from the Taiwan National Health Insurance database. Hazard ratios (HRs) of stroke risk for ovarian cancer patients compared with an age- and comorbidity-matched cohort were calculated by Cox proportional regression analysis. The difference in cumulative ischemic stroke incidence between ovarian cancer patients and the matched cohort was analyzed with the Kaplan-Meier method and tested with the log-rank test.ResultsEach cohort (ovarian cancer and matched cohort) consisted of 8,810 individuals, with a median age of 49 years. After a median follow-up of 2.68 and 3.85 years, respectively, the ischemic stroke incidence was 1.38-fold higher in the ovarian cancer cohort than in the comparison cohort (9.4 versus 6.8 per 1,000 person-years), with an age- and comorbidity-adjusted HR of 1.49 (P <0.001). The ischemic stroke risk imposed by ovarian cancer was more prominent in patients under 50 years old (HR 2.28; P <0.001) compared with patients 50 years and older (HR 1.33; P = 0.005). Significant risk factors predicting stroke development were age 50 years and older (HR 2.21; P <0.001), hypertension (HR 1.84; P <0.001), diabetes mellitus (HR 1.71; P <0.001), and treatment with chemotherapy (HR 1.45; P = 0.017), especially platinum-based regimens.ConclusionsOvarian cancer patients were at an increased risk of developing ischemic stroke. Age, hypertension, diabetes, and chemotherapy treatment were independent risk factors.

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Section: Discussionmentioning

confidence: 99%

Risk of ischemic stroke in patients with ovarian cancer: a nationwide population-based study

Kuan

Teng

et al. 2014

BMC Med

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“…Other causes could be increased serum viscosity, erythrocyte aggregation, and increased fibrogen and platelet factor 4 [4]. Rarely, intra-tumoral hemorrhage of an ovarian tumor could also lead to DIC [5]. This may have been the case in our patient.…”

Section: Discussionmentioning

confidence: 72%

Sex Cord Stromal Tumors–Unusual Presentations

Mehta

Rajaram

Goel

et al. 2011

J Obstet Gynecol India

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AbstractsObjectives The sex cord stromal tumors (SCST) account for approximately 7% of all malignant ovarian tumors. They are endocrinologically active tumors of which granulosa cell tumors are the commonest. We describe an analysis of all cases of SCST managed, in our department over the last five years and discuss two cases of unusual presentation of these tumors. Methods Ten cases of SCST which were managed in the Department of Gynecology and Obstetrics at University College of Medical Sciences (UCMS) & associated Guru Teg Bahadur hospital, Delhi from Jan. 01 to Dec. 05 were analyzed. Results Of the total 312 ovarian tumors which were operated in these 5 years, 73 (23.3%) were malignant, 10 cases (13.6%) out of the malignant ovarian tumors were SCST. The age of presentation varied from 4 to 70 years. Four women presented with lump abdomen as their chief complaint, 2 had postmenopausal bleeding, 2 presented with irregular bleeding per-vaginum, 1 woman had secondary amenorrhea and one young girl who was only 4 years old developed precocious puberty. The majority of cases (70%) were granulosa cell tumors, 10% were fibromas and 20% thecomas. Maximum patients 9 (90%) were stage I at the time of surgery and only 1 case was stage IV with tumor infiltrating into omentum and gut. Conclusion SCST tumors are rare endocrine active tumors that are essentially unilateral, benign or with a low malignant potential. Though most patients present with one or a combination of symptoms ranging from abnormal vaginal bleeding, abdominal distention and abdominal pain, the signs of Paraneoplastic syndrome (PNS) may be the first indication of the presence of an ovarian malignancy and can even facilitate its diagnosis.

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Paraneoplastic consumptive coagulopathy related to intramyometrial low-grade endometrial stromal sarcoma coexistent with adenomyosis diagnosed 7 years after laparoscopic-assisted myomectomy

Takeda

Imoto

Mori

et al. 2010

Arch Gynecol Obstet

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Disseminated Intravascular Coagulation Associated with Intratumoral Hemorrhage of Ovarian Cancer

Cited by 7 publications

References 7 publications

Risk of ischemic stroke in patients with ovarian cancer: a nationwide population-based study

Risk of ischemic stroke in patients with ovarian cancer: a nationwide population-based study

Sex Cord Stromal Tumors–Unusual Presentations

Paraneoplastic consumptive coagulopathy related to intramyometrial low-grade endometrial stromal sarcoma coexistent with adenomyosis diagnosed 7 years after laparoscopic-assisted myomectomy

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