Paraneoplastic syndrome in mice bearing high-angiogenic variant of Lewis lung carcinoma: Relations with tumor derived VEGF

Fedorchuk, O. G.; Pyaskovskaya, O N; Skivka, Larysa; Gorbik, G. V.; Trompak, Omelyan; Solyanik, G I

doi:10.1016/j.cyto.2011.10.022

Cited by 8 publications

(4 citation statements)

References 29 publications

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“…It is known that progression of LLC is accompanied with moderate splenomegalymanifestation of a hematological paraneoplastic syndrome [85]. The weight of the spleen of mice undergoing any treatment (including C 60 +Cis complex) was significantly lower than in the control (untreated) group of LLC bearing mice.…”

Section: Antitumor Action In Vivomentioning

confidence: 93%

C60 fullerene enhances cisplatin anticancer activity and overcomes tumor cell drug resistance

et al. 2016

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A novel nano-formulation of the anticancer drug cisplatin (Cis) with C 60 fullerene (C 60 +Cis complex) was developed, demonstrating enhanced cytotoxic activity towards tumor cell lines in vitro n comparison to Cis alone. The enhanced proapoptotic activity of the novel complexes was found to be tightly connected with their unique capability to circumvent cancer drug resistance in vitro, as revealed by investigation of human leukemia cells HL-60 together with their sublines resistant towards doxorubicin (HL-60/adr, multidrug resistance protein-1=MRP-1=ABCC1 overexpressing) and vincristine (HL-60/vinc, P-glycoprotein=P-gp=ABCB1 overexpressing). The enhanced anticancer activity of the developed С 60 +Cis complexes was also confirmed in vivo on male C57BL/6J mice bearing Lewis lung carcinoma, effectively inhibiting tumor growth and formation of metastases in comparison to free single Cis. For better understanding of molecular mechanisms underlying the potential ability of the С 60 +Cis complexes to circumvent cancer drug resistance, a molecular docking study was conducted. This analysis demonstrated the potential capability of C 60 fullerene to form van der Waals interactions with potential binding sites of P-gp, MRP-1and MRP-2 (ABCC2) molecules, with maximum affinity to MRP-2. The observed phenomenon might indicate the mechanism how the C 60 +Cis complex bypasses drug resistance of cancer cells by direct binding to ABC transporter proteins. Additionally, the results of Ames mutagenicity test demonstrated that immobilization of Cis on С 60 fullerene significantly diminishes mutagenic activity of Cis and may reduce the probability of secondary neoplasms induction. Concluding, the synthesized C 60 +Cis complex effectively induces cancer cell death in vitro and inhibits tumor growth in vivo, circumventing cancer cell resistance to chemotherapy due to the specific affinity of C 60 fullerene towards ABC-transporter proteins. The obtained results indicate the C 60 +Cis complex as a promising novel chemotherapeutic agentespecially for treatment of drug-resistant tumors.

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Section: Antitumor Action In Vivomentioning

confidence: 93%

C60 fullerene enhances cisplatin anticancer activity and overcomes tumor cell drug resistance

et al. 2016

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“…The lungs were removed and the number of metastases in the lungs and their diameter were assessed using a binocular magnifying glass and a millimeter ruler. The volume of lung metastases (Vmet) was calculated accounting their number and size by the formula [ 17 ]:

where n i – number of metastases with diameter d i. (mm).…”

Section: Methodsmentioning

confidence: 99%

Mitochondrial dysfunction significantly contributes to the sensitivity of tumor cells to anoikis and their metastatic potential

Solyanik,

Kolesnik,

Prokhorova

et al. 2024

Heliyon

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“…3, А) у відсутності змін їх поглинальної активності. У попередніх дослідженнях нами показано, що ріст карциноми легені Льюїс супроводжуєтсья розвитком паранеопластичного гематологічного синдрому [16], тому суттєве зменшення кількості перитонеальних макрофагів може бути наслідком системного впливу пухлинного процесу. Після хірургічного видалення пухлини кількість фагоцитуючих клітин у перитонеальній порожнині контрольних тварин та тварин,котрі отримали анальгезію з омнопоном, відновлювалася до значень інтактних тварин, а у групі декскетопрофену перевищувала показник тварин інших груп, більше, ніж в 1,5 разів.…”

Section: рис 2 показники фагоцитарної активності моноцитів мишей доunclassified

The effect of analgesia with omnopon and dexketoprofen on the endocytic activity of phagocytes of different localization on the surgical tumor resection model

Khranovska¹,

Skachkova²,

Sydor

et al. 2016

BTSNUKSPPFR

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We aimed to compare the effect of anesthesia with opioid analgesics omnopon and non-selective COX-2 inhibitor dexketoprofen on the endocytic activity of phagocytes of different localization sites on the model of surgical tumor removal. The study used 50 C57/black mice, which were transplanted with Lewis lung carcinoma in the hind paw pad. After 22 days the tumor paw was amputated. Analgesics (omnopon 10 mg/kg, dexketoprofen – 20 mg/kg) was administered 30 minutes before the operation and once per day for 3 days after surgery. Assessment of endocytic activity of phagocytes was performed by flow cytometry before the surgery, at days 1 and 3 after the surgery. It was found that dexketoprofen analgesia maintain the endocytic activity of blood and spleen phagocytes in the postoperative period. At day 3 postsurgery in dexketoprofen- treated animals phagocytic activities of blood and spleen granulocytes were higher compared to the group receiving opioid analgesia by 70% and 86% respectively. Phagocytic indices of blood and spleen monocytes were also 2 times higher at dexketoprofen-treated mice. Thus, dexketoprofen analgesia maintains the activity of blood and spleen phagocytes in mice after the surgical tumor removal at a much higher level as compared with the omnopon analgesia.

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Paraneoplastic syndrome in mice bearing high-angiogenic variant of Lewis lung carcinoma: Relations with tumor derived VEGF

Cited by 8 publications

References 29 publications

C60 fullerene enhances cisplatin anticancer activity and overcomes tumor cell drug resistance

C60 fullerene enhances cisplatin anticancer activity and overcomes tumor cell drug resistance

Mitochondrial dysfunction significantly contributes to the sensitivity of tumor cells to anoikis and their metastatic potential

The effect of analgesia with omnopon and dexketoprofen on the endocytic activity of phagocytes of different localization on the surgical tumor resection model

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