Paraneoplastic optic neuropathy secondary to adenocarcinoma of the lung

Abstract

We describe an uncommon cause of paraneoplastic optic neuropathy in adenocarcinoma of the lung. A 45-year-old healthy woman presented with seizure and encephalitis, followed by an acute visual loss in both eyes for 1 week. Her visual acuity was no perception of light in the right eye and hand movement in the left eye. There was a generalised restriction of extraocular muscle movements in both eyes. Funduscopy showed a bilateral pale optic disc. A paraneoplastic antigen autoimmune profile showed a positive anti-CV2/CRMP-5 antibody. CT of the thorax revealed the presence of right apical lung mass, confirmed to be adenocarcinoma through a biopsy. She was scheduled for lung lobectomy and chemotherapy. Unfortunately, her health deteriorated and she passed away eventually.

Rare case of anti-CV2 paraneoplastic polyneuropathy associated with lung adenocarcinoma

“…Multiple previous case reports have reported an association between anti-CV2 and small cell lung cancer;10 however, to the best of our knowledge, there is only one reported case of lung adenocarcinoma with paraneoplastic syndrome exhibiting neurological symptoms. The patient was described to exhibit paraneoplastic optic neuropathy with positive anti-CV2 antibody 11. Anti-CV2 antibody is also more commonly associated with cerebellar ataxia, myasthenic syndromes rather than peripheral neuropathy 12.…”