Paraneoplastic Cloudy Vitelliform Submaculopathy in Primary Vitreoretinal Lymphoma

Pang, Claudine E.; Shields, Carol L.; Jumper, J. Michael; Yannuzzi, Lawrence A.

doi:10.1016/j.ajo.2014.08.031

Cited by 34 publications

(29 citation statements)

References 42 publications

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“…This high-grade malignancy often has a stuttering onset with intermittent blurred vision and mild vitreous inflammatory cells, sometimes with “cloudy” paraneoplastic subretinal infiltration, best seen on OCT, as in our case. [ 1 2 ] Ocular management typically involves intravitreal chemotherapy or radiotherapy. Despite ocular control, systemic prognosis is guarded depending on brain involvement.…”

Section: Discussionmentioning

confidence: 99%

Soft drusen or not?

Shields

Elimimian

Manjandavida³

2018

Indian J Ophthalmol

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Section: Discussionmentioning

confidence: 99%

Soft drusen or not?

Shields

Elimimian

Manjandavida³

2018

Indian J Ophthalmol

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“…In 2014, Pang et al reported three cases in which vitelliform submaculopathy preceded typical lesions of PIOL [ 3 ]. Our case has several different features in clinical course, unlike their cases.…”

Section: Discussionmentioning

confidence: 99%

“…The disease is typical of masquerade syndromes and is often difficult to diagnose if no characteristic vitreous haze or subretinal focus is present. In 2014, Pang et al described three cases in which vitelliform submaculopathy preceded typical lesions of PIOL, as the first report of this event [ 3 ]. Foci in those cases spontaneously disappeared in a brief period, with a subsequently diagnosis of PIOL.…”

Section: Introductionmentioning

confidence: 99%

Atypical presentation of primary intraocular lymphoma

et al. 2016

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BackgroundIn 2014, Pang et al. reported three cases with vitelliform submaculopathy as a preceding lesion of primary intraocular lymphoma (PIOL). Here, we report a case with an atypical presentation of PIOL who initially presented with vitelliform submaculopathy, vitreous haze and preripheral retinal focus.Case presentationA 73-year-old female initially visited another hospital with a chief complaint of acute reduced vision in the right eye. Funduscopic examination of the right eye showed a yellowish retinal lesion at the fovea with vitreous haze and retinal foci scattered in the peripheral region. Spectral-domain optic coherence tomography (SD-OCT) revealed a hyperreflective subretinal debris above the retinal pigment epithelium (RPE) at the fovea, suggesting vitelliform submaculopathy. Vitrectomy was performed to improve visualization of the retinal lesions and for examination of PIOL. Vitreous cytology was class III and cytokine analysis of vitreous fluid showed increased IL-10 and an IL-10/IL-6 ratio >1, suggesting PIOL. Thereafter, there was a sub-RPE infiltration of presumed lymphoma in the nasal retina, and PCR analysis of anterior chamber fluid indicated IgH gene rearrangement, leading to diagnosis of PIOL. Three months later, there was complete disappearance of the vitelliform submacular lesion, with resultant disruption and thinning of the outer retinal layers on SD-OCT images.ConclusionsClinicians should be aware of atypical manifestations of PIOL such as vitelliform submaculopathy and peripheral retinal foci with vitreous haze. The patient’s unusual funduscopic changes are findings that have not reported in patients with PIOL.

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“…26 However, acquired vitelliform lesions has been associated with a variety of retinal conditions, like retinal dystrophies, reticular pseudodrusen, cuticular drusen, pseudoxanthoma elasticum, central serous chorioretinopathy, macular telangiectasia type 2, RPE detachment, vitreomacular interface disease, immunogammapathies, drug toxicity, and paraneoplastic syndromes. [26][27][28][29][30][31][32][33] We think that this may represent an incident finding in our patient, unrelated to ECD. Therefore, in our series, the most advanced multimodal chorioretinal imaging techniques have not shown any signs of subclinical intraocular involvement related to ECD in asymptomatic patients.…”

Section: Abnormal 11mentioning

confidence: 99%

<p>Multimodal Chorioretinal Imaging in Erdheim-Chester Disease</p>

Sacconi¹,

Campochiaro²,

Rabiolo³

et al. 2020

OPTH

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To analyze the subclinical intraocular involvement using multimodal imaging approach in patients affected by Erdheim-Chester disease (ECD) without ocular symptoms. Patients and Methods: In this prospective cross-sectional study, 18 eyes of 9 consecutive patients with ECD were enrolled. Each patient underwent comprehensive ocular examination and extensive multimodal chorioretinal imaging. Results: None of the patients presented any evidence of chorioretinal localization of disease using multimodal imaging. One patient exhibited a choroidal nevus complicated by active polypoidal choroidal neovascularization. Subretinal hyperreflective material was seen in three eyes, mainly resembling acquired vitelliform lesion. One patient had an isolated intraretinal hemorrhage. Most patients exhibited peripheral vascular abnormalities (ie, microaneurysms, peripheral vascular leakage). Fundus autofluorescence showed faint hyperautofluorescence in eleven eyes. Conclusion: Intraocular involvement is an extremely rare event of an extremely rare disease. In patients affected by ECD without ocular symptoms, advance multimodal imaging examinations did not show signs of subclinical chorioretinal involvement related to the disease.

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Paraneoplastic Cloudy Vitelliform Submaculopathy in Primary Vitreoretinal Lymphoma

Cited by 34 publications

References 42 publications

Soft drusen or not?

Soft drusen or not?

Atypical presentation of primary intraocular lymphoma

<p>Multimodal Chorioretinal Imaging in Erdheim-Chester Disease</p>

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