Paraneoplastic Amyotrophic Lateral Sclerosis: Case Series and Literature Review

Yang, Zhao; He, Lu; Ren, Manli; Lu, Yizhou; Meng, Huanyu; Ding, Yin; Chen, Sheng; Zhou, Qinming

doi:10.3390/brainsci12081053

Cited by 5 publications

(3 citation statements)

References 21 publications

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“…There is inadequate evidence and inconsistent data in the literature on the function of B lymphocytes, plasma cells, and antibodies in neuroinflammation and ND [54,55], and their contribution in AD pathogenesis needs further investigation. The diverse and obscure points of neuroinflammation and ND [56] could also be clarified.…”

Section: Clonotypic Immune Cells In Neuroinflammation and Ndmentioning

confidence: 99%

Neuroinflammation and Neurodegenerative Diseases: How Much Do We Still Not Know?

Balistreri,

Monastero

2023

Brain Sciences

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The term “neuroinflammation” defines the typical inflammatory response of the brain closely related to the onset of many neurodegenerative diseases (NDs). Neuroinflammation is well known, but its mechanisms and pathways are not entirely comprehended. Some progresses have been achieved through many efforts and research. Consequently, new cellular and molecular mechanisms, diverse and conventional, are emerging. In listing some of those that will be the subject of our description and discussion, essential are the important roles of peripheral and infiltrated monocytes and clonotypic cells, alterations in the gut–brain axis, dysregulation of the apelinergic system, alterations in the endothelial glycocalyx of the endothelial component of neuronal vascular units, variations in expression of some genes and levels of the encoding molecules by the action of microRNAs (miRNAs), or other epigenetic factors and distinctive transcriptional factors, as well as the role of autophagy, ferroptosis, sex differences, and modifications in the circadian cycle. Such mechanisms can add significantly to understanding the complex etiological puzzle of neuroinflammation and ND. In addition, they could represent biomarkers and targets of ND, which is increasing in the elderly.

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Section: Clonotypic Immune Cells In Neuroinflammation and Ndmentioning

confidence: 99%

Neuroinflammation and Neurodegenerative Diseases: How Much Do We Still Not Know?

Balistreri,

Monastero

2023

Brain Sciences

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“…Cases of paraneoplastic ALS with specific anti-neuronal antibodies deserve particular attention, because these are extremely rare forms of the disease; thus, definitively diagnosing these forms is difficult. However, the description of some of these forms in a recent review [ 24 ] suggests that there may be an interaction between cancer and neurodegeneration in ALS which is mediated by the immune system.…”

Section: Recent Evidence On Clonotypic Immunity In Alsmentioning

confidence: 99%

Advances on Cellular Clonotypic Immunity in Amyotrophic Lateral Sclerosis

Schirò

Stefano²,

Iacono³

et al. 2022

Brain Sciences

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Amyotrophic lateral sclerosis (ALS) is a fatal neuromuscular disease, characterized by the progressive degeneration of the upper and lower motor neurons in the cortex and spinal cord. Although the pathogenesis of ALS remains unclear, evidence concerning the role of the clonotypic immune system is growing. Adaptive immunity cells often appear changed in number, or in terms of their activation profiles, both peripherally and centrally; however, their role in ALS appears conflictive. Data from human and animal model studies, which are currently reported in the literature, show that each subset of lymphocytes and their mediators may mediate a protective or toxic mechanism in ALS, affecting both its progression and risk of death. In the present review, an attempt is made to shed light on the actual role of cellular clonotypic immunity in ALS by integrating recent clinical studies and experimental observations.

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“…However, the description of some of these forms in a recent review (21) suggests that there may be an interaction between cancer and neurodegeneration in ALS mediated by the immune system.…”

Section: Recent Evidence On Clonotypic Immunity In Aslmentioning

confidence: 99%

Advances on Cellular Clonotypic Immunity in Amyotrophic Lateral Sclerosis

Schirò¹,

Stefano²,

Brighina³

et al. 2022

Preprint

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Amyotrophic lateral sclerosis (ALS) is a fatal neuromuscular disease, characterized by progressive degeneration of upper and lower motor neurons in the cortex and spinal cord. Although the pathogenesis of ALS remains unclear, evidence on the role of the clonotypic immune system is growing. Adaptive immunity cells often appear changed in number or activation profile peripherally and centrally. However, their role in ALS appears conflicting. Data, from human and animal model studies, currently reported in literature show that each subset of lymphocytes and their mediators may mediate a protective or toxic mechanism in ALS, affecting both its progression and risk of death. In the present review article and attempt is made to shed light on the actual role of the cellular clonotypic immunity in ALS by integrating recent clinical studies and experimental observations.

show abstract

Paraneoplastic Amyotrophic Lateral Sclerosis: Case Series and Literature Review

Cited by 5 publications

References 21 publications

Neuroinflammation and Neurodegenerative Diseases: How Much Do We Still Not Know?

Neuroinflammation and Neurodegenerative Diseases: How Much Do We Still Not Know?

Advances on Cellular Clonotypic Immunity in Amyotrophic Lateral Sclerosis

Advances on Cellular Clonotypic Immunity in Amyotrophic Lateral Sclerosis

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