Paramyxovirus Antigens in Osteoclasts from Paget's Bone Tissue Detected by Monoclonal Antibodies

Basle, Michel‐Félix; Russell, W. C.; Goswami, K. K. A.; Rèbel, A; Giraudon, Pascale; Wild, Fabian; Filmon, R.

doi:10.1099/0022-1317-66-10-2103

Cited by 87 publications

(25 citation statements)

References 24 publications

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“…OCLs from individuals with Paget's disease contain nuclear and cytoplasmic inclusions that have been reported to cross-react with antibodies to nucleocapsids from paramyxoviruses, including MV, respiratory syncytial virus, and canine distemper virus (4)(5)(6)(7)(8). Our previous studies have suggested that MV is the most common virus detectable in the patients we have studied.…”

Section: Discussionmentioning

confidence: 99%

Osteoclasts expressing the measles virus nucleocapsid gene display a pagetic phenotype

et al. 2000

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Section: Discussionmentioning

confidence: 99%

Osteoclasts expressing the measles virus nucleocapsid gene display a pagetic phenotype

et al. 2000

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“…The pagetic osteoclasts are greatly increased in number and size and have increased numbers of nuclei compared with normal osteoclasts (5)(6)(7). The pagetic osteoclasts have viral-like nuclear and cytoplasmic inclusions and express viral antigens and viral transcripts for paramyxoviruses (8)(9)(10)(11)(12)(13)(14), which suggests a possible viral etiology for Paget's disease. However, the mechanisms responsible for the enhanced osteoclast formation seen in this disease are unknown.…”

Section: Introductionmentioning

confidence: 99%

Interleukin 6. A potential autocrine/paracrine factor in Paget's disease of bone.

Roodman¹,

Kurihara²,

Ohsaki³

et al. 1992

J. Clin. Invest.

347

156

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Pagetic osteoclasts are greatly increased in number and size and have increased numbers of nuclei per cell compared to normal osteoclasts. The mechanisms responsible for enhanced osteoclast formation in Paget's disease are unknown. We have used our recently described model system for pagetic osteoclast formation to evaluate culture media conditioned by these atypical multinucleated cells (MNC) to determine if pagetic osteo-

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“…Persistent infection of the virus has been documented in various clinical situations (8)(9)(10). Moreover, reinfection after a primary infection with HPIV3 is a common occurrence (1,6).…”

mentioning

confidence: 99%

Infection and immunoregulation of T lymphocytes by parainfluenza virus type 3.

Sieg¹,

Muro-Cacho²,

Robertson³

et al. 1994

Proc. Natl. Acad. Sci. U.S.A.

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Human paanfluenza virus type 3 (HPIV3) is a major cause of dise In newborns and Infants. It also has a king potential to reinfect individuals throughout their lives, suggesting that HPIV3 does not induce lifelong immunity; however, the operative mechanism for the failure to prevent reinfection is not known. We have as d the potential of the virus to infect nontransformed human Tlymphocytes and have found that T cells are readily infected by the virus. Productive infection requires activation of the T cells and results in a marked inhibition of proliferation. Furthermore, our results indicate that exposure to the virus, even without overt expression of viral proteins as det by imunohistol, profoundly alters the functional capacity of the T cells. The capacity of the virus to regulate T-lymphocyte function may play an important role In the failure of the virus to induce lifelong immunity.Human parainfluenza virus type 3 (HPIV3) causes severe respiratory tract infections in infants and children (1-5) and upper respiratory tract infections in adults (6-8). It is efficiently spread from person-to-person (5, 6); consequently, all adults possess anti-HPIV3 immunoglobulins (6).Persistent infection of the virus has been documented in various clinical situations (8-10). Moreover, reinfection after a primary infection with HPIV3 is a common occurrence (1,6). In one study the frequency of HPIV3 reinfection was found to be 58% in 1-year-old children and 34% in 2-year-old children (1). Even in the presence of circulating neutralizing antibodies, adults have been shown to be susceptible to reinfection (6). This clinical characteristic is distinct from infection with either measles or mumps viruses, which result in lifelong immunity against reinfection. It appears that infection with HPIV3 does not result in the establishment of a state of long-lasting immunity (11).The mechanisms for persistent infection or for reinfection with HPIV3 have not been determined; however, it is likely that the equilibrium between the human host and the viral parasite arises as a result ofthe complex interactions between the host's immune system and the virus. One significant aspect of this interaction is infection of T lymphocytes by viruses. Viral infection of T lymphocytes has been demonstrated for many different viruses and has been shown to profoundly alter the immune response (12-15). Although T cells have the potential to lyse virally infected cells, help B lymphocytes produce immunoglobulins, and establish longlived memory cells, the possibility that HPIV3-mediated immunoregulation of T lymphocytes plays a role in either persistence or reinfection has not been considered.In this report we demonstrate that HPIV3 has a marked immunoregulatory effect on human T lymphocytes even in the absence of productive infection as detected by immunohistology. Experiments were also performed by infecting the PBMC with HPIV3 without washing out the virus. The results from these experiments were similar to the results from experiments that were perfo...

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Paramyxovirus Antigens in Osteoclasts from Paget's Bone Tissue Detected by Monoclonal Antibodies

Cited by 87 publications

References 24 publications

Osteoclasts expressing the measles virus nucleocapsid gene display a pagetic phenotype

Osteoclasts expressing the measles virus nucleocapsid gene display a pagetic phenotype

Interleukin 6. A potential autocrine/paracrine factor in Paget's disease of bone.

Infection and immunoregulation of T lymphocytes by parainfluenza virus type 3.

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