Parametrically Dissociating Speech and Nonspeech Perception in the Brain Using fMRI

Benson, Randall R.; Whalen, D. H.; Richardson, Matthew; Swainson, Brook; Clark, Vincent P.; Lai, Song; Liberman, Alvin M.

doi:10.1006/brln.2001.2484

Cited by 136 publications

(78 citation statements)

References 104 publications

(133 reference statements)

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“…This suggests that these two regions may play different roles. The involvement of the temporal cortex in the speech non-speech contrast is congruent with several studies showing that the superior temporal region responds more strongly to speech than to non-speech sounds (Belin et al, 2002;Benson et al, 2001;Binder et al, 2000;Jäncke et al, 2002;Perani et al, 1996;Vouloumanos et al, 2001). In a meta-analysis of four studies, Binder et al (2000) reported that the mean of the peaks of significant activation differences for speech and non-speech sounds is at x = À55.5 (SD 2.3), y = À20.2 (SD 10.9), z = 0.3 (SD 4.1) in the left hemisphere.…”

Section: Fmrisupporting

confidence: 88%

Neural correlates of switching from auditory to speech perception

et al. 2005

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Many people exposed to sinewave analogues of speech first report hearing them as electronic glissando and, later, when they switch into a dspeech modeT, hearing them as syllables. This perceptual switch modifies their discrimination abilities, enhancing perception of differences that cross phonemic boundaries while diminishing perception of differences within phonemic categories. Using high-density evoked potentials and fMRI in a discrimination paradigm, we studied the changes in brain activity that are related to this change in perception. With ERPs, we observed that phonemic coding is faster than acoustic coding: The electrophysiological mismatch response (MMR) occurred earlier for a phonemic change than for an equivalent acoustic change. The MMR topography was also more asymmetric for a phonemic change than for an acoustic change. In fMRI, activations were also significantly asymmetric, favoring the left hemisphere in both perception modes. Furthermore, switching to the speech mode significantly enhanced activation in the posterior parts of the left superior gyrus and sulcus relative to the non-speech mode. When responses to a change of stimulus were studied, a cluster of voxels in the supramarginal gyrus was activated significantly more by a phonemic change than by an acoustic change. These results demonstrate that phoneme perception in adults relies on a specific and highly efficient left-hemispheric network, which can be activated in top-down fashion when processing ambiguous speech/non-speech stimuli.

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Section: Fmrisupporting

confidence: 88%

Neural correlates of switching from auditory to speech perception

et al. 2005

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“…Located in the inferior parietal lobule, the angular gyrus serves as a multimodal association area, facilitating mental processes such as arithmetic (Arsalidou & Taylor, 2011), visuospatial attention (Nobre et al., 1997), memory (Kim, 2010; Spaniol et al., 2009; Vilberg & Rugg, 2008) sequence learning (Rosenthal, Roche‐Kelly, Husain, & Kennard, 2009), and semantic processing (Benson et al., 2001; Obleser, Wise, Dresner, & Scott, 2007; Price, Peelle, Bonner, Grossman, & Hamilton, 2016; Price, 2012). Further, the posterior aspect of the angular gyrus serves as part of the default mode network (DMN), which is most active during rest or fixation and becomes deactivated when performing cognitive tasks.…”

Section: Discussionmentioning

confidence: 99%

Altered resting‐state functional connectivity of the putamen and internal globus pallidus is related to speech impairment in Parkinson's disease

et al. 2018

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IntroductionSpeech impairment in Parkinson's disease (PD) is pervasive, with life‐impacting consequences. Yet, little is known about how functional connections between the basal ganglia and cortex relate to PD speech impairment (PDSI). Whole‐brain resting‐state connectivity analyses of basal ganglia nuclei can expand the understanding of PDSI pathophysiology.MethodsResting‐state data from 89 right‐handed subjects were downloaded from the Parkinson's Progression Markers Initiative database. Subjects included 12 older healthy controls (“OHC”), 42 PD patients without speech impairment (“PDN”), and 35 PD subjects with speech impairment (“PDSI”). Subjects were assigned to PDN and PDSI groups based on the Movement Disorders Society Unified Parkinson's Disease Rating Scale (MDS‐UPDRS) Part III speech item scores (“0” vs. “1–4”). Whole‐brain functional connectivity was calculated for four basal ganglia seeds in each hemisphere: putamen, caudate, external globus pallidus (GPe), and internal globus pallidus (GPi). For each seed region, group‐averaged connectivity maps were compared among OHC, PDN, and PDSI groups using a multivariate ANCOVA controlling for the effects of age and sex. Subsequent planned pairwise t‐tests were performed to determine differences between the three groups using a voxel‐wise threshold of p < 0.001 and cluster‐extent threshold of 272 mm3 (FWE<0.05).ResultsIn comparison with OHCs, both PDN and PDSI groups demonstrated significant differences in cortical connectivity with bilateral putamen, bilateral GPe, and right caudate. Compared to the PDN group, the PDSI subjects demonstrated significant differences in cortical connectivity with left putamen and left GPi. PDSI subjects had lower connectivity between the left putamen and left superior temporal gyrus compared to PDN. In addition, PDSI subjects had greater connectivity between left GPi and three cortical regions: left dorsal premotor/laryngeal motor cortex, left angular gyrus, and right angular gyrus.ConclusionsThe present findings suggest that speech impairment in PD is associated with altered cortical connectivity with left putamen and left GPi.

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“…We examined the posterior ST and an expanded set of motor brain areas: Broca's, cerebellum, precentral gyrus, and left precentral sulcus. Adult data implicate these areas in speech processing (36)(37)(38)(39)(40)(41)(42)(43)(44)(45)(46)(47)(48)(49)(50)(61)(62)(63). We were especially interested in the cerebellum because our recent whole-brain voxel-based morphometry study demonstrated that concentrations of white-and gray-matter in cerebellar areas at 7 mo predict infants' language development at 1 y of age (64).…”

Section: Methodsmentioning

confidence: 99%

“…Cortical Speech Motor Areas Activated During Speech Perception: Adult Evidence In adults, phonetic tasks activate left hemisphere areas implicated in speech production, including Broca's, the cerebellum, premotor cortex (PMC), and anterior insula, in addition to auditory brain regions, such as the superior temporal gyrus (STG) (36)(37)(38)(39)(40). These data were interpreted as consistent with the idea that speech production experience enables generation of internal motor models of speech, which are compared with incoming sensory data, as envisioned by AxS (41)(42)(43).…”

Section: The Role Of Action In Speech Perceptionmentioning

confidence: 99%

Infants’ brain responses to speech suggest Analysis by Synthesis

Kuhl

Ramírez

Bosseler

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

196

143

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Significance Infants discriminate speech sounds universally until 8 mo of age, then native discrimination improves and nonnative discrimination declines. Using magnetoencephalography, we investigate the contribution of auditory and motor brain systems to this developmental transition. We show that 7-mo-old infants activate auditory and motor brain areas similarly for native and nonnative sounds; by 11–12 mo, greater activation in auditory brain areas occurs for native sounds, whereas greater activation in motor brain areas occurs for nonnative sounds, matching the adult pattern. We posit that hearing speech invokes an Analysis by Synthesis process: auditory analysis of speech is coupled with synthesis that predicts the motor plans necessary to produce it. Both brain systems contribute to the developmental transition in infant speech perception.

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Parametrically Dissociating Speech and Nonspeech Perception in the Brain Using fMRI

Cited by 136 publications

References 104 publications

Neural correlates of switching from auditory to speech perception

Neural correlates of switching from auditory to speech perception

Altered resting‐state functional connectivity of the putamen and internal globus pallidus is related to speech impairment in Parkinson's disease

Infants’ brain responses to speech suggest Analysis by Synthesis

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