Altered resting‐state functional connectivity of the putamen and internal globus pallidus is related to speech impairment in Parkinson's disease

Manes, Jordan L.; Tjaden, Kris; Parrish, Todd B.; Simuni, Tanya; Roberts, Angela; Greenlee, Jeremy D.W.; Corcos, Daniel M.; Kurani, Ajay S.

doi:10.1002/brb3.1073

Cited by 34 publications

(27 citation statements)

References 76 publications

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“…Here, we analyzed the altered CBF‐connectivity of unilateral BA subregions involved in the pathophysiology of asymmetry in PD. We found reduced CBF‐connectivity between the left ITG and the left putamen, as well as the left globus pallidus, in PD patients, which is similar to the results of other studies using BOLD (Manes et al, 2018). Interestingly, we discovered even worse connections in the PDL group when subdivisions were related to laterality.…”

Section: Discussionsupporting

confidence: 91%

Motor asymmetry related cerebral perfusion patterns in Parkinson's disease: An arterial spin labeling study

Shang

Zhang

et al. 2020

Human Brain Mapping

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Persisting asymmetry of motor symptoms are characteristic of Parkinson's disease (PD). We investigated the possible lateralized effects on regional cerebral blood flow (CBF), CBF-connectivity, and laterality index (LI) among PD subtypes using arterial spin labeling (ASL). Forty-four left-sided symptom dominance patients (PDL), fortyeight right-sided symptom dominance patients (PDR), and forty-five matched HCs were included. Group comparisons were performed for the regional normalized CBF, CBF-connectivity and LI of basal ganglia (BA) subregions. The PDL patients had lower CBF in right calcarine sulcus and right supramarginal gyrus compared to the PDR and the HC subjects. Regional perfusion alterations seemed more extensive in the PDL than in the PDR group. In the PDL, correlations were identified between right thalamus and motor severity, between right fusiform gyrus and global cognitive performance. None of correlations survived after multiple comparisons correction. The significantly altered CBF-connectivity among the three groups included: unilateral putamen, unilateral globus pallidus, and right thalamus. LI score in the putamen was significantly different among groups. Motor-symptom laterality in PD may exhibit asymmetric regional and interregional abnormalities of CBF properties, particularly in PDL patients. This preliminary study underlines the necessity of classifying PD subgroups based on asymmetric motor symptoms and the potential application of CBF properties underlying neuropathology in PD.

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Section: Discussionsupporting

confidence: 91%

Motor asymmetry related cerebral perfusion patterns in Parkinson's disease: An arterial spin labeling study

Shang

Zhang

et al. 2020

Human Brain Mapping

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“…Due to technical reasons, we did not differentiate between GPi and GPe. Although differential extraction and time series analysis of GPi and GPe is feasible (Manes et al, 2018), in our preprocessing process <20 voxels for each GPi survived; therefore we extracted the globus pallidus as a whole.…”

Section: Discussionmentioning

confidence: 99%

Cause or effect: Altered brain and network activity in cervical dystonia is partially normalized by botulinum toxin treatment

Brodoehl

Wagner

Prell

et al. 2019

NeuroImage: Clinical

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Background Idiopathic cervical dystonia (CD) is a chronic movement disorder characterized by impressive clinical symptoms and the lack of clear pathological findings in clinical diagnostics and imaging. At present, the injection of botulinum toxin (BNT) in dystonic muscles is an effective therapy to control motor symptoms and pain in CD. Objectives We hypothesized that, although it is locally injected to dystonic muscles, BNT application leads to changes in brain and network activity towards normal brain function. Methods Using 3 T functional MR imaging along with advanced analysis techniques (functional connectivity, Granger causality, and regional homogeneity), we aimed to characterize brain activity in CD (17 CD patients vs. 17 controls) and to uncover the effects of BNT treatment (at 6 months). Results In CD, we observed an increased information flow within the basal ganglia, the thalamus, and the sensorimotor cortex. In parallel, some of these structures became less responsive to regulating inputs. Furthermore, our results suggested an altered somatosensory integration. Following BNT administration, we noted a shift towards normal brain function in the CD patients, especially within the motor cortex, the somatosensory cortex, and the basal ganglia. Conclusion The changes in brain function and network activity in CD can be interpreted as related to the underlying cause, the effort to compensate or a mixture of both. Although BNT is applied in the last stage of the cortico-neuromuscular pathway, brain patterns are shifted towards those of healthy controls.

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“…Although assessed in less of the studies reviewed, there were associations between reduced motor function and increased striatal iron content, as well as, increased iron in the Putamen and increased disability scores, such as, Dementia rating scale, Extended disability status score and the UPDRS-III for rating of Parkinson's pathology. Due to its many neurological roles and connections, atrophy in the Putamen is known to be involved in pathology of several diseases such as, Parkinson's disease, Multiple Sclerosis and Dementia with Lewy Bodies [78][79][80][81]. The striatum consists of the caudate and putamen and is crucial for connections to the basal ganglia which is heavily involved in motor control [82].…”

Section: Plos Onementioning

confidence: 99%

The impact of brain iron accumulation on cognition: A systematic review

2020

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Iron is involved in many processes in the brain including, myelin generation, mitochondrial function, synthesis of ATP and DNA and the cycling of neurotransmitters. Disruption of normal iron homeostasis can result in iron accumulation in the brain, which in turn can partake in interactions which amplify oxidative damage. The development of MRI techniques for quantifying brain iron has allowed for the characterisation of the impact that brain iron has on cognition and neurodegeneration. This review uses a systematic approach to collate and evaluate the current literature which explores the relationship between brain iron and cognition. The following databases were searched in keeping with a predetermined inclusion criterion: Embase Ovid, PubMed and PsychInfo (from inception to 31 st March 2020). The included studies were assessed for study characteristics and quality and their results were extracted and summarised. This review identified 41 human studies of varying design, which statistically assessed the relationship between brain iron and cognition. The most consistently reported interactions were in the Caudate nuclei, where increasing iron correlated poorer memory and general cognitive performance in adulthood. There were also consistent reports of a correlation between increased Hippocampal and Thalamic iron and poorer memory performance, as well as, between iron in the Putamen and Globus Pallidus and general cognition. We conclude that there is consistent evidence that brain iron is detrimental to cognitive health, however, more longitudinal studies will be required to fully understand this relationship and to determine whether iron occurs as a primary cause or secondary effect of cognitive decline.

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Altered resting‐state functional connectivity of the putamen and internal globus pallidus is related to speech impairment in Parkinson's disease

Cited by 34 publications

References 76 publications

Motor asymmetry related cerebral perfusion patterns in Parkinson's disease: An arterial spin labeling study

Motor asymmetry related cerebral perfusion patterns in Parkinson's disease: An arterial spin labeling study

Cause or effect: Altered brain and network activity in cervical dystonia is partially normalized by botulinum toxin treatment

The impact of brain iron accumulation on cognition: A systematic review

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