Paramètres de radiorésistance des cancers des voies aérodigestives supérieures et stratégies de radiosensibilisation

Biau, J.; Chautard, Emmanuel; Miroir, J.; Lapeyre, M.

doi:10.1016/j.canrad.2015.02.014

Cited by 9 publications

(3 citation statements)

References 104 publications

(111 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Due to the anatomical specificity and invasiveness, inflammation is common in the sphenoid sinus and nasal cavity in advanced T stage NPC and often combines with necrosis and bacterial infections, which results in local hypoxia and radioresistance. This was also observed in head and neck cancers [ 13 – 16 ]. Moreover, numerous previous studies showed that hypoxia is also an adverse prognostic factor in many malignant cancers like lung, breast, uterine cervix, rectum, brain, soft tissue and renal cell [ 17 – 23 ].…”

Section: Discussionsupporting

confidence: 57%

Primary tumor inflammation in gross tumor volume as a prognostic factor for nasopharyngeal carcinoma patients

Peng

Chen²,

TANG³

et al. 2016

Oncotarget

View full text Add to dashboard Cite

PurposeThe objective of this study is to investigate the prognostic value of primary tumor inflammation (PTI) in nasopharyngeal carcinoma (NPC) in the era of intensity-modulated radiation therapy (IMRT).ResultsPTI was observed in 376/1708 (22.0%) patients, and was present in the sphenoid sinus in 289/376 (76.9%), in the nasal cavity in 27 (7.2%), and in both places in 60 (15.9%). The estimated 4-year local relapse-free survival (LRFS), disease-free survival (DFS), overall survival (OS) and distant metastasis-free survival (DMFS) rates for PTI vs. non-PTI group were 89.2% vs. 96.1% (P < 0.001), 73.4% vs. 85.1% (P < 0.001), 85.0% vs. 92.1% (P < 0.001) and 83.6% vs. 91.4% (P < 0.001), respectively. After adjustment for these known prognostic factors, PTI was confirmed as an independent prognostic factor for LRFS (HR 2.152, 95% CI 1.318–3.516, P = 0.002), DFS (HR 1.581, 95% CI 1.204–2.077, P = 0.001) and DMFS (HR 1.682, 95% CI 1.177–2.402, P = 0.004).ConclusionsPrimary tumor inflammation was identified as a strong prognostic factor for patients with NPC in the era of IMRT and should be considered when devising future treatment strategies aimed at improving survival in NPC patients.Materials and MethodsData on 1708 patients with nonmetastatic, histologically-confirmed NPC treated with IMRT between November 2009 and February 2012 at Sun Yat-Sen University Cancer Center were retrospectively reviewed. Patient survival between PTI and non-PTI groups were compared.

show abstract

Section: Discussionsupporting

confidence: 57%

Primary tumor inflammation in gross tumor volume as a prognostic factor for nasopharyngeal carcinoma patients

Peng

Chen²,

TANG³

et al. 2016

Oncotarget

View full text Add to dashboard Cite

show abstract

“…Jusqu'au début des années 1980, les traitements locaux (chirurgie et/ou radiothérapie) étaient les composants clés du traitement des cancers des cancers des voies aérodigestives supérieures localement évolués [2][3][4] avec un risque important de rechute locale ou à distance et un fort taux de morbidité [5,6]. Pour améliorer les taux de guérison et les résultats fonctionnels, la chimiothérapie a été intégrée dans différentes stratégies qui incluent la chimioradiothérapie concomitante, la chimiothérapie d'induction et la combinaison d'une chimiothérapie d'induction et d'une chimioradiothérapie concomitante [1]. Ces stratégies ont été appliquées chez des patients avec des cancers non opérables [7][8][9][10][11][12][13][14][15][16][17][18] reste donc une option pour certains patients mais ne constitue pas le traitement standard de ce type de tumeurs et sa place dans l'arsenal thérapeutique reste à définir [36,37].…”

Section: Introductionunclassified

“…Les cancers des voies aérodigestives supérieures sont au cinquième rang de la mortalité par cancer en France [1]. La majorité de ces cancers sont diagnostiqués alors qu'ils sont localement évolués.…”

Section: Introductionunclassified

Toxicité de la chimiothérapie d’induction par docétaxel, platine, 5-fluorouracile (TPF) pour les cancers des voies aérodigestives supérieures localement évolués en routine clinique : importance du statut nutritionnel

Bernadach

Lapeyre

Dillies

et al. 2019

Cancer/Radiothérapie

Self Cite

View full text Add to dashboard Cite

The effects of hemoglobin levels and their interactions with cigarette smoking on survival in nasopharyngeal carcinoma patients

Zeng

Shen

et al. 2016

Cancer Medicine

View full text Add to dashboard Cite

There is very little published information regarding the prognostic value of hemoglobin (Hb) levels combined with smoking on the survival of patients with nasopharyngeal carcinoma (NPC), and the interactions between them remain unclear. A total of 2440 NPC patients were confirmed, and multivariate analysis was performed to identify valuable prognostic Hb levels in the entire population and in the cohort of smokers. The survival differences were compared using log‐rank tests. The multiplicative and additive interactions were assessed using Cox regression and a Microsoft Word Excel spreadsheet. Postradiotherapy (RT) Hb was an independent prognostic factor for overall survival (OS) (HR = 0.797; P = 0.006), failure‐free survival (FFS) (HR=0.811; P = 0.010), and loco‐regional failure‐free survival (LR‐FFS) (HR = 0.725; P = 0.000). In the cohort of smokers, pack‐years was also an independent predictor of OS (HR = 0.673; P < 0.001) and FFS (HR = 0.681; P < 0.001), LR‐FFS (HR = 0.663; P = 0.001). A significant positive additive effect was found for the interaction between low post‐RT Hb and high SI on OS, with RERI = 5.616, AP = 0.665, and S = 4.078. Stratified analyses demonstrated that heavy smokers with low post‐RT Hb had HRs of 2.295 (P < 0.001) for death, 2.222 (P < 0.001) for disease failure, and 2.267 (P < 0.001) loco‐regional recurrence compared with light smokers with high post‐RT Hb levels, and post‐RT Hb level is an important predictor of survival in patients with NPC. The positive interaction between post‐RT Hb level and pack‐years contributes to the elevated risk of poor survival. Oncologists should devote particular attention to heavy smokers with low post‐RT Hb levels in the future.

show abstract

Paramètres de radiorésistance des cancers des voies aérodigestives supérieures et stratégies de radiosensibilisation

Cited by 9 publications

References 104 publications

Primary tumor inflammation in gross tumor volume as a prognostic factor for nasopharyngeal carcinoma patients

Primary tumor inflammation in gross tumor volume as a prognostic factor for nasopharyngeal carcinoma patients

Toxicité de la chimiothérapie d’induction par docétaxel, platine, 5-fluorouracile (TPF) pour les cancers des voies aérodigestives supérieures localement évolués en routine clinique : importance du statut nutritionnel

The effects of hemoglobin levels and their interactions with cigarette smoking on survival in nasopharyngeal carcinoma patients

Contact Info

Product

Resources

About