Background: Based on the hypothesis of synergistic effect of avelumab with cetuximab and radiotherapy, this new combination is tested in a randomised trial against two wellestablished standard of care (SOC) in locally advanced squamous-cell carcinoma of the head and neck (LA-SCCHN). Methods: This phase III trial comprises two cohorts of patients deemed fit to receive cisplatin (100 mg/m 2 Q3W) (cohort 1) or unfit to cisplatin (cohort 2). The SOC was Intensity
Background: Based on a potential synergistic effect of antiePD-L1 avelumab plus cetuximab and radiotherapy (RT), this combination was tested in a randomized phase III trial against 2 standards of care (SOC) in LA-SCCHN.
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