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2012
DOI: 10.1002/jssc.201200647
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Parameters optimization of supercritical fluid‐CO2 extracts of frankincense using response surface methodology and its pharmacodynamics effects

Abstract: The volatile oil parts of frankincense (Boswellia carterii Birdw.) were extracted with supercritical carbon dioxide under constant pressure (15, 20, or 25 MPa) and fixed temperature (40, 50, or 60°C), given time (60, 90, or 120 min) aiming at the acquisition of enriched fractions containing octyl acetate, compounds of pharmaceutical interest. A mathematical model was created by Box-Behnken design, a popular template for response surface methodology, for the extraction process. The response value was characteri… Show more

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Cited by 13 publications
(7 citation statements)
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“…The volatile oil parts of frankincense (Boswellia carterii) was extracted with SC CO 2 under constant pressure (15,20,or 25 MPa) and fixed temperature (40, 50, or 60 °C) at given times (60, 90, or 120 min) aiming at the acquisition of enriched fractions containing octyl acetate, a compound of pharmaceutical interest. This study demonstrates that SFE is a feasible method for selective acquisition of volatile oil from B. carterii being 20 Mpa, 55 °C and 94 min the best conditions to obtain the target compounds in higher amounts [79].…”
Section: Supercritical Fluid Extraction Of Fragrancesmentioning
confidence: 73%
“…The volatile oil parts of frankincense (Boswellia carterii) was extracted with SC CO 2 under constant pressure (15,20,or 25 MPa) and fixed temperature (40, 50, or 60 °C) at given times (60, 90, or 120 min) aiming at the acquisition of enriched fractions containing octyl acetate, a compound of pharmaceutical interest. This study demonstrates that SFE is a feasible method for selective acquisition of volatile oil from B. carterii being 20 Mpa, 55 °C and 94 min the best conditions to obtain the target compounds in higher amounts [79].…”
Section: Supercritical Fluid Extraction Of Fragrancesmentioning
confidence: 73%
“…Thus, response surface methodology (RSM) was implemented in this study to optimize experimental parameters, to model and also to analyze the response of interest along, as well as to reduce the number of experiments. Previously, RSM has been successfully utilized to optimize the parameters of several biotechnological processes such as solubilization, biosorption, supercritical process, and fermentation [26][27][28]. It has also been widely used to optimize ELM parameters in extraction of chromium, bisphenol, and DL-tryptophan [22,29,30].…”
Section: Introductionmentioning
confidence: 99%
“…This method is time consuming and troublesome and ignores the interaction effects of the parameters. Compared to the classical methods, the response surface methodology (RSM) is more efficient, requires fewer data and provides the interaction effects of the response besides the factor effects [13,14].…”
Section: Introductionmentioning
confidence: 99%