Parallelized multi–graphics processing unit framework for high-speed Gabor-domain optical coherence microscopy

Tankam, Patrice; Santhanam, Anand P.; Lee, Kye-Sung; Won, Jungeun; Canavesi, Cristina; Rolland, Jannick P.

doi:10.1117/1.jbo.19.7.071410

Cited by 23 publications

(9 citation statements)

References 72 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We recently leveraged the capability of graphic processing units (Two NVIDIA GTX Titan cards) to allow real time acquisition and visualization of high resolution images. 34 …”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Optical Assessment of Soft Contact Lens Edge-Thickness

et al. 2016

Self Cite

View full text Add to dashboard Cite

Purpose To assess the edge shape of soft contact lenses using Gabor-Domain Optical Coherence Microscopy (GD-OCM) with a 2 μm imaging resolution in three dimensions, and to generate edge-thickness profiles at different distances from the edge tip of soft contact lenses. Methods A high-speed custom-designed GD-OCM system was used to produce 3D images of the edge of an experimental soft contact lens (Bausch + Lomb, Rochester NY) in four different configurations: in air, submerged into water, submerged into saline with contrast agent, and placed onto the cornea of a porcine eyeball. An algorithm to compute the edge-thickness was developed and applied to cross-sectional images. The proposed algorithm includes the accurate detection of the interfaces between the lens and the environment, and the correction of the refraction error. Results The sharply defined edge tip of a soft contact lens was visualized in 3D. Results showed precise thickness measurement of the contact lens edge profile. 50 cross-sectional image frames for each configuration were used to test the robustness of the algorithm in evaluating the edge-thickness at any distance from the edge tip. The precision of the measurements was less than 0.2 μm. Conclusions The results confirmed the ability of GD-OCM to provide high definition images of soft contact lens edges. As a non-destructive, precise, and fast metrology tool for soft contact lens measurement, the integration of GD-OCM in the design and manufacturing of contact lenses will be beneficial for further improvement in edge design and quality control. In the clinical perspective, the in-vivo evaluation of the lens fitted onto the cornea will advance our understanding of how the edge interacts with the ocular surface. The latter will provide insights into the impact of long-term use of contact lenses on the visual performance.

show abstract

“…We recently leveraged the capability of graphic processing units (Two NVIDIA GTX Titan cards) to allow real time acquisition and visualization of high resolution images. 34 …”

Section: Methodsmentioning

confidence: 99%

“…The acquisition time of the 3D image was 30 seconds and the visualization of the sample was made possible within 13 seconds of the acquisition time using the parallelized GPU processing. 34 For each measurement, 1000 frames, each containing 1000 pixels (A-scans), were saved for further image analysis.…”

Section: Methodsmentioning

confidence: 99%

Optical Assessment of Soft Contact Lens Edge-Thickness

et al. 2016

Self Cite

View full text Add to dashboard Cite

show abstract

“…As example of a GDOCM image of a human fingertip acquired with three zones and the corresponding fusing procedure is shown in Figure 4. Parallel processing of the acquired data on graphics processing units (GPUs) achieves near real-time visualization of the volumetric images [28].…”

Section: Gabor-domain Optical Coherence Microscopymentioning

confidence: 99%

Ten Years of Gabor-Domain Optical Coherence Microscopy

Canavesi

Rolland

2019

Applied Sciences

Self Cite

View full text Add to dashboard Cite

Gabor-domain optical coherence microscopy (GDOCM) is a high-definition imaging technique leveraging principles of low-coherence interferometry, liquid lens technology, high-speed imaging, and precision scanning. GDOCM achieves isotropic 2 μm resolution in 3D, effectively breaking the cellular resolution limit of optical coherence tomography (OCT). In the ten years since its introduction, GDOCM has been used for cellular imaging in 3D in a number of clinical applications, including dermatology, oncology and ophthalmology, as well as to characterize materials in industrial applications. Future developments will enhance the structural imaging capability of GDOCM by adding functional modalities, such as fluorescence and elastography, by estimating thicknesses on the nano-scale, and by incorporating machine learning techniques.

show abstract

“…Although we leveraged the parallel computing toolbox, the CPU computing is fundamentally limited by the number of cores available. In future work, we plan to leverage the GPU framework we recently implemented in our lab to significantly speed up the post processing time and allow for real time visualization of thickness maps [23]. Fig.…”

Section: Processing Speedmentioning

confidence: 99%

Measurement of a multi-layered tear film phantom using optical coherence tomography and statistical decision theory

Huang¹,

Yuan²,

Zhang³

et al. 2014

Biomed. Opt. Express

Self Cite

View full text Add to dashboard Cite

To extend our understanding of tear film dynamics for the management of dry eye disease, we propose a method to optically sense the tear film and estimate simultaneously the thicknesses of the lipid and aqueous layers. The proposed method, SDT-OCT, combines ultra-high axial resolution optical coherence tomography (OCT) and a robust estimator based on statistical decision theory (SDT) to achieve thickness measurements at the nanometer scale. Unlike conventional Fourier-domain OCT where peak detection of layers occurs in Fourier space, in SDT-OCT thickness is estimated using statistical decision theory directly on the raw spectra acquired with the OCT system. In this paper, we demonstrate in simulation that a customized OCT system tailored to ~1 µm axial point spread function (FWHM) in the corneal tissue, combined with the maximum-likelihood estimator, can estimate thicknesses of the nanometer-scale lipid and micron-scale aqueous layers of the tear film, simultaneously, with nanometer precision. This capability was validated in experiments using a physical phantom that consists of two layers of optical coatings that mimic the lipid and aqueous layers of the tear film.

show abstract

Parallelized multi–graphics processing unit framework for high-speed Gabor-domain optical coherence microscopy

Cited by 23 publications

References 72 publications

Optical Assessment of Soft Contact Lens Edge-Thickness

Optical Assessment of Soft Contact Lens Edge-Thickness

Ten Years of Gabor-Domain Optical Coherence Microscopy

Measurement of a multi-layered tear film phantom using optical coherence tomography and statistical decision theory

Contact Info

Product

Resources

About