Parallelism of intestinal secretory IgA shapes functional microbial fitness

Rollenske, Tim; Burkhalter, Sophie; Muerner, Lukas; Gunten, Stephan von; Łukasiewicz, Jolanta; Wardemann, Hedda; Macpherson, Andrew J.

doi:10.1038/s41586-021-03973-7

Cited by 81 publications

(75 citation statements)

References 50 publications

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“…197 Similar disparate antibody responses to distinct genetic phase variations of a single bacterium species have also been reported. 129 Although, at baseline, intestinal fungi are bound by only low amounts of mucosal IgG, this can be increased rapidly by adding ex vivo of serum IgG in both humans and mice. 193 This IgG is antigen-specific, dependent on T cell presence for its generation and significantly lowered in germ-free mice.…”

Section: Igg Class Switching In Inflammatory Bowel Diseasementioning

confidence: 99%

B cell class switching in intestinal immunity in health and disease

2022

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Section: Igg Class Switching In Inflammatory Bowel Diseasementioning

confidence: 99%

B cell class switching in intestinal immunity in health and disease

2022

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“…Via inhibition of bacterial/viral adhesion and neutralization of toxins and pathogenic microorganisms, mucosal sIgA acts as an important first line of defense. Studies in germ-free mice have demonstrated that the production of sIgA on the mucosa gets kickstarted after introduction of even a single microbial strain [28 ▪▪ ]. Following, sIgA remains to some level dependent on the microbiota and can be altered by introduction of specific bacteria as demonstrated by Yang et al They show that oral inoculation of a combination of specific human strains of Bacteriodes ovatus can induce fecal sIgA levels in germ-free mice and these antibodies coat the microbiota, suggesting that these antibodies can target bacteria [9 ▪▪ ].…”

Section: Resultsmentioning

confidence: 99%

The microbiota in respiratory tract infections: from association to intervention

Koenen

Piters

Bogaert

et al. 2022

Current Opinion in Infectious Diseases

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Purpose of reviewThe respiratory microbiota has a role in respiratory tract infection (RTI) pathogenesis. On the mucosa, the respiratory microbiota interacts with potential pathogenic viruses, bacteria and the host immune system, including secretory IgA (sIgA). This review discusses the role of the respiratory microbiota and its interaction with the (mucosal) immune system in RTI susceptibility, as well as the potential to exploit the microbiota to promote health and prevent RTIs. Recent findingsRecent studies confirm that specific microbiota profiles are associated with RTI susceptibility and during susceptibility and found accompanying RTIs, although clear associations have not yet been found for SARS-CoV-2 infection. sIgA plays a central role in RTI pathogenesis: it stands under control of the local microbiota, while at the same time influencing bacterial gene expression, metabolism and defense mechanisms. Respiratory microbiota interventions are still newly emerging but promising candidates for probiotics to prevent RTIs, such as Corynebacterium and Dolosigranulum species, have been identified.

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“…But, currently, no data are available regarding the affinity with which intestinal SIgA binds these molecules in vivo . Recently, Rollenske et al (2021) mapped the collection of SIgAs produced in mice in response to colonization by a single Escherichia coli strain. They identified IgAs targeting a variety of bacterial antigens, including cell wall lipopolysaccharides (LPS), type I fimbriae, and outer membrane proteins (OmpW and OmpC).…”

Section: Siga-microbiota Interactionsmentioning

confidence: 99%

Roles of Secretory Immunoglobulin A in Host-Microbiota Interactions in the Gut Ecosystem

Leon

Francino²

2022

Front. Microbiol.

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In the gastrointestinal tract (GIT), the immune system interacts with a variety of microorganisms, including pathogens as well as beneficial symbionts that perform important physiological functions for the host and are crucial to sustain intestinal homeostasis. In normal conditions, secretory immunoglobulin A (SIgA) is the principal antibody produced by B cells in the GIT mucosa. Polyreactivity provides certain SIgA molecules with the ability of binding different antigens in the bacterial surface, such as O-antigens and teichoic acids, while cross-species reactivity allows them to recognize and interact with different types of bacteria. These functions may be crucial in allowing SIgA to modulate the complex gut microbiota in an efficient manner. Several studies suggest that SIgA can help with the retention and proliferation of helpful members of the gut microbiota. Gut microbiota alterations in people with IgA deficiency include the lack of some species that are known to be normally coated by SIgA. Here, we discuss the different ways in which SIgA behaves in relation to pathogens and beneficial bacteria of the gut microbiota and how the immune system might protect and facilitate the establishment and maintenance of certain gut symbionts.

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Parallelism of intestinal secretory IgA shapes functional microbial fitness

Cited by 81 publications

References 50 publications

B cell class switching in intestinal immunity in health and disease

B cell class switching in intestinal immunity in health and disease

The microbiota in respiratory tract infections: from association to intervention

Roles of Secretory Immunoglobulin A in Host-Microbiota Interactions in the Gut Ecosystem

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