2012
DOI: 10.1016/j.tig.2012.01.005
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Parallel mechanisms of epigenetic reprogramming in the germline

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Cited by 164 publications
(168 citation statements)
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“…Extensive epigenetic programming and reprogramming occurs in the germ cell lineage following the specification of PGCs (Hajkova et al 2002;Lee et al 2002;Seki et al 2005Seki et al , 2007Hajkova et al 2008Hajkova et al , 2010Popp et al 2010;Guibert et al 2012;Hackett et al 2012Kobayashi et al 2012;Seisenberger et al 2012;Vincent et al 2013;Yamaguchi et al 2013). This period of development is marked by the erasure of some of the repressive epigenetic modifications (Fig.…”
Section: Regulation Of Epigenetic Programming After Pgc Specificationmentioning
confidence: 99%
“…Extensive epigenetic programming and reprogramming occurs in the germ cell lineage following the specification of PGCs (Hajkova et al 2002;Lee et al 2002;Seki et al 2005Seki et al , 2007Hajkova et al 2008Hajkova et al , 2010Popp et al 2010;Guibert et al 2012;Hackett et al 2012Kobayashi et al 2012;Seisenberger et al 2012;Vincent et al 2013;Yamaguchi et al 2013). This period of development is marked by the erasure of some of the repressive epigenetic modifications (Fig.…”
Section: Regulation Of Epigenetic Programming After Pgc Specificationmentioning
confidence: 99%
“…In response to BMPs and WNTs from adjacent tissues, few cells in the posterior region of the proximal epiblast become the founders of the germline. Establishment of the germ cell fate relies on a distinct transcriptional program and a set of epigenetic regulators (Hackett et al 2012, Magnusdottir et al 2012. In particular, Prdm1 (also known as Blimp1) is necessary to repress the ongoing transcriptional program of somatic cells and Prdm14 activates the re-expression of pluripotency genes , Yamaji et al 2008.…”
Section: Pgc Formation Outside the Gonads Is The First Stage Of Gametmentioning
confidence: 99%
“…To establish the germline, the somatic program must be inhibited and pluripotency reacquired. Before and after reaching their final residence in the gonadal ridges, PGCs undergo unique genome-wide modifications, including imprinting erasure, that enable them to embark into gametogenesis (Hackett et al 2012, Magnusdottir et al 2012. In particular, in female mammals, PGCs, called in some species oogonia after their settling into the gonadal ridges, proliferate to give rise to primary meiotic oocytes, which are subsequently enclosed in primordial follicles.…”
Section: Introductionmentioning
confidence: 99%
“…DNA methylation needs to be faithfully maintained throughout the life cycle, since loss of DNA methylation can result in gene dosage problems, dysregulation of gene expression, and genomic instability due to retrotransposon reactivation [1]. Nevertheless, genome-wide loss of DNA methylation has been observed during germ cell development [2] and in the paternal pronucleus soon after fertilization [3].…”
mentioning
confidence: 99%