“…To establish the germline, the somatic program must be inhibited and pluripotency reacquired. Before and after reaching their final residence in the gonadal ridges, PGCs undergo unique genome-wide modifications, including imprinting erasure, that enable them to embark into gametogenesis (Hackett et al 2012, Magnusdottir et al 2012. In particular, in female mammals, PGCs, called in some species oogonia after their settling into the gonadal ridges, proliferate to give rise to primary meiotic oocytes, which are subsequently enclosed in primordial follicles.…”