Parallel increase of plasma apoproteins C‐II and C‐III in Type 2 diabetic patients

Béliard, Sophie; Nogueira, Juan Patricio; Maraninchi, Marie; Lairon, Denis; Nicolay, Alain; Giral, Philippe; Portugal, Henri; Vialettes, B.; Valéro, René

doi:10.1111/j.1464-5491.2009.02757.x

Cited by 26 publications

(24 citation statements)

References 19 publications

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“…In this study, we have confirmed that a high level of insulin resistance is a driving parameter in the pathophysiology of the dyslipidaemia seen in the MAO group compared to the MOA and LHO groups and found the typical lipid profile: increased plasma triglycerides, apoB-100, apoB-48, apoC-III and apoC-II, and decreased HDL-c and apoA-I. The same total apoC-III/apoC-II ratios between the subgroups of obese patients suggest that this parallel increase in apoproteins having opposite functional effects in the TRL clearing process is most likely secondary to the increase of plasma TRL, as we have previously reported for type 2 diabetic patients [18]. In our multiple regression analysis, adiponectin levels were strongly and positively correlated with the HDL-c levels and were negatively correlated with TG levels independently of BMI, insulin resistance and hs-CRP levels.…”

Section: Discussionsupporting

confidence: 71%

Unacylated Ghrelin is associated with the isolated low HDL-cholesterol obese phenotype independently of insulin resistance and CRP level

et al. 2012

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BackgroundLow plasma high-density lipoprotein-cholesterol (HDL-c) level is commonly present in obesity and represents an independent cardiovascular risk factor. However, obese patients are a very heterogeneous population and the factors and mechanisms that contribute to low HDL-c remain unclear. The aim of this study was to investigate the association between plasma HDL-c levels and plasma hormonal profiles (insulin, adiponectin, resistin, leptin and ghrelin) in subsets of class II and III obese patients.MethodsFasting plasma levels of glucose, total cholesterol, LDL-c, HDL-c, triglycerides, free fatty acids, apoproteins A-I, B-100, B-48, C-II, C-III, insulin, hs-CRP, adipocytokines (adiponectin, resistin, leptin), unacylated ghrelin, body composition (DXA) and resting energy expenditure were measured in three subsets of obese patients: 17 metabolically abnormal obese (MAO) with metabolic syndrome and the typical metabolic dyslipidaemia, 21 metabolically healthy obese (MHO) without metabolic syndrome and with a normal lipid profile, and 21 isolated low HDL-c obese patients (LHO) without metabolic syndrome, compared to 21 healthy lean control subjects.ResultsInsulin resistance (HOMA-IR) increased gradually from MHO to LHO and from LHO to MAO patients (p < 0.05 between MHO and MAO and between LHO and MAO). In multiple regression analysis, serum unacylated ghrelin levels were only positively and independently associated with HDL-c levels in the LHO group (p = 0.032).ConclusionsThese results suggest that, in class II and III obese patients with an isolated low HDL-c phenotype, unacylated ghrelin is positively associated with HDL-c level independently of insulin resistance and CRP levels, and may contribute to the highly prevalent low HDL-c level seen in obesity.

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Section: Discussionsupporting

confidence: 71%

Unacylated Ghrelin is associated with the isolated low HDL-cholesterol obese phenotype independently of insulin resistance and CRP level

et al. 2012

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“…A high-carbohydrate diet has been associated with increased apoC-II concentrations relative to apoC-III in VLDL 79 . The increased apoC-II levels in DM type 2 84 and chronic renal failure 85 are associated with elevated TG in plasma. Because the plasma levels of TRL even in the postprandial state are usually far less than 0.5 µmol/L, there is enough apoC-II to exist in multiple copies per TRL particle.…”

Section: Apoc-ii Biochemistrymentioning

confidence: 96%

Apolipoprotein C-II: New findings related to genetics, biochemistry, and role in triglyceride metabolism

et al. 2017

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Apolipoprotein C-II (apoC-II) is a small exchangeable apolipoprotein found on triglyceride-rich lipoproteins (TRL), such as chylomicrons (CM) and very low-density lipoproteins (VLDL), and on high-density lipoproteins (HDL), particularly during fasting. ApoC-II plays a critical role in TRL metabolism by acting as a cofactor of lipoprotein lipase (LPL), the main enzyme that hydrolyses plasma triglycerides (TG) on TRL. Here, we present an overview of the role of apoC-II in TG metabolism, emphasizing recent novel findings regarding its transcriptional regulation and biochemistry. We also review the 24 genetic mutations in the APOC2 gene reported to date that cause hypertriglyceridemia (HTG). Finally, we describe the clinical presentation of apoC-II deficiency and assess the current therapeutic approaches, as well as potential novel emerging therapies.

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“…Béliard et al [44] found increased total ApoC-II concentrations in type 2 diabetic patients compared to healthy control subjects. The peak detected at 3,774 Da may be an alternative representation of CGRP-1 (also suggested for the peak detected at 3,816 Da) or glucagon-like peptide 2 (GLP-2).…”

Section: Discussionmentioning

confidence: 99%

“…Increased levels of apoC-III have been found in type 2 diabetic patients [44], and one study reported high apoC-III levels to be a major diabetogenic factor [49]. …”

Section: Discussionmentioning

confidence: 99%

Association between protein signals and type 2 diabetes incidence

et al. 2012

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Understanding early determinants of type 2 diabetes is essential for refining disease prevention strategies. Proteomic technology may provide a useful approach to identify novel protein patterns potentially related to pathophysiological changes that lead up to diabetes. In this study, we sought to identify protein signals that are associated with diabetes incidence in a middle-aged population. Serum samples from 519 participants in a nested case–control selection (167 cases and 352 age-, sex- and BMI-matched normoglycemic control subjects, median follow-up 14.0 years) within the Whitehall-II cohort were analyzed by linear matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS). Nine protein peaks were found to be associated with incident diabetes. Rate ratios for high peak intensity ranged between 0.4 (95% CI, 0.2–0.8) and 4.0 (95% CI, 1.7–9.2) and were robust to adjustment for main potential confounders, including obesity, lipids and C-reactive protein. The proteins associated with these peaks may reflect diabetes pathogenesis. Our study exemplifies the utility of an approach that combines proteomic and epidemiological data.

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Parallel increase of plasma apoproteins C‐II and C‐III in Type 2 diabetic patients

Abstract: Our study shows the parallel increase of apoC-II and C-III in Type 2 diabetic patients. This parallel increase is related to hypertriglyceridaemia only.

Cited by 26 publications

References 19 publications

Unacylated Ghrelin is associated with the isolated low HDL-cholesterol obese phenotype independently of insulin resistance and CRP level

Unacylated Ghrelin is associated with the isolated low HDL-cholesterol obese phenotype independently of insulin resistance and CRP level

Apolipoprotein C-II: New findings related to genetics, biochemistry, and role in triglyceride metabolism

Association between protein signals and type 2 diabetes incidence

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