“…Following, the complete reading of each article resulted in 14 exclusions of studies on AD and seven on T2DM: a) AD – five studies did not identify the proteins (only the molecular mass); three evaluated only the protein glycosylation profile, or novel Aβ peptides species and one of them evaluated the lipidomic profile; two studies failed to include a control group or investigated only patients with mild cognitive impairment (MCI); one study evaluated the proteomics by machine learning without describing the relevant proteins; two studies applied the proteomic methodology in brain tissue or cerebrospinal fluid (CSF); and proteomic techniques were not used in the last study; b) T2DM – two studies failed to identify the proteins or to include a healthy control group; four investigated only the glycosylation profile or proteins turnover, or protein post‐translational modification; one study applied proteomic approaches in mononuclear peripheral cells. Thirty‐four of the 40 studies were classified as HQ by fulfilling at least 9/14 criteria of QUADOMICS (Abdulwahab, Alaiya, Shinwari, Allaith, & Giha, 2019; Chiu et al., 2018; Cocciolo et al, 2012; Craig‐Schapiro et al, 2010; Dayon et al., 2017; Dey et al., 2019; Dincer et al., 2009; Fania et al., 2017; Gómez‐Cardona et al., 2017; González‐Sánchez et al, 2008; Hu et al., 2012; Huth et al., 2019; Hye et al., 2006; IJsselstijn et al., 2011; Jensen et al., 2013; Kitamura et al., 2017; Li et al., 2008, 2018; Liu et al., 2006, 2009; Llano, Devanarayan, & Simon, 2013; Meng et al, 2017; Muenchhoff et al, 2017; Nazeri et al., 2014; Nowak et al., 2016; Park et al., 2019; Ray et al., 2007; Riaz, Alam, & Akhtar, 2010; Sattlecker et al., 2014; Shen et al., 2017; Soares et al., 2009; Zabel et al., 2012; Zhang et al., 2008; Zhao et al., 2015). The six remaining studies were classified as LQ, reaching less than 9/14 queries (Bennett et al., 2012; Johnstone, Milward, Berretta, Moscato, & Initiative, 2012; Kang et al., 2016; Long, Pan, Ifeachor, Belshaw, & Li, 2016; Yang, Lyutvinskiy, Soininen, & Zubarev, 2011; Yang ...…”