Paragonimus and paragonimiasis

Yokogawa, Sadamu; Cort, William W.; Yokogawa, M.

doi:10.1016/0014-4894(60)90088-6

Cited by 63 publications

(29 citation statements)

References 61 publications

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“…A number of culinary dishes have been linked with paragonimiasis. These include the Chinese and Korean dish "kejeng," wherein live crustaceans are eaten with soybean sauce (80), and the Japanese dish "oboro-kiro," wherein crab juice is added to bean paste (miso) soup (80,158,203). Paragonimiasis in Mexico has been associated with cerviche that contains uncooked crustaceans (Hugo Vicente Ralde, personal communication).…”

Section: Epidemiology Of Human Diseasementioning

confidence: 99%

North American Paragonimiasis (Caused by Paragonimus kellicotti ) in the Context of Global Paragonimiasis

2009

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SUMMARY Paragonimus species are highly evolved parasites with a complex life cycle that involves at least three different hosts, i.e., snails, crustaceans, and mammals. The adult forms of Paragonimus species reside and mate in the lungs of a variety of permissive mammalian hosts, including humans. Although human paragonimiasis is uncommonly encountered in North America, both autochthonous and imported disease may be encountered. Paragonimus kellicotti, the species endemic to North America, is a well-known pathogen in wild and domestic animals. Five patients with North American paragonimiasis have been reported in the recent medical literature. The biologic, clinical, radiologic, and laboratory features of paragonimiasis are reviewed, with emphasis on North American paragonimiasis whenever possible.

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Section: Epidemiology Of Human Diseasementioning

confidence: 99%

North American Paragonimiasis (Caused by Paragonimus kellicotti ) in the Context of Global Paragonimiasis

2009

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“…In particular, some protein hydrolysates have been shown to exert hypolipidemic and anti-obesity effects in high-fat diet (HFD)-fed obese animal models (18–21). The melanian snail, Semisulcospira libertina , is one of the most commonly encountered freshwater snails in Far East Asia, and has been used as an ingredient of tonic functional foods in Korea (22–24). …”

Section: Introductionmentioning

confidence: 99%

Blood glycemia-modulating effects of melanian snail protein hydrolysates in mice with type II diabetes

Choi¹,

Kim²,

Park³

et al. 2017

International Journal of Molecular Medicine

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Abstract. Freshwater animal proteins have long been used as nutrient supplements. In this study, melanian snail (Semisulcospira libertina) protein hydrolysates (MPh) were found to exert anti-diabetic and protective effects against liver and kidney damage in mice with type II diabetes adapted to a 45% kcal high-fat diet (HFD). The hypoglycemic, hepatoprotective and nephroprotective effects of MPh were analyzed after 12 weeks of the continuous oral administration of MPh at 125, 250 and 500 mg/kg. Diabetic control mice exhibited an increase in body weight, and blood glucose and insulin levels, with a decrease in serum high-density lipoprotein (HDL) levels. In addition, an increase in the regions of steatohepatitis, hepatocyte hypertrophy, and lipid droplet deposit-related renal tubular vacuolation degenerative lesions were detected, with noticeable expansion and hyperplasia of the pancreatic islets, and an increase in glucagon-and insulin-producing cells, insulin/glucagon cell ratios in the endocrine pancreas and hepatic lipid peroxidation, as well as decreased zymogen contents. Furthermore, a deterioration of the endogenous antioxidant defense system was observed, with reduced glucose utilization related hepatic glucokinase (GK) activity and an increase in hepatic gluconeogenesis-related phosphoenolpyruvate carboxykinase (PEPCK) and glucose-6-phosphatase (G6pase) activity. However, all of these diabetic complications were significantly inhibited by oral treatment with MPh in a dose-dependent manner. In addition, the marked dose-dependent inhibition of hepatic lipid peroxidation, the depletion of the liver endogenous antioxidant defense system, and changes in hepatic glucose-regulating enzyme activities were also observed. The results of this study suggest that MPh exerts potent anti-diabetic effects, along with the amelioration of related complications in mice with type II diabetes. The overall effects of MPh at a dose of 125 mg/kg on HFD-induced diabetes and related complications were similar or more potent than those of metformin (250 mg/kg).

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“…Dietary changes forced by war have been linked to outbreaks of paragonimiasis in Japan, Southeast Asia, and Nigeria, where the unavailability of other foods to fleeing refugees and the fear that fires might attract hostile attention led to the consumption of uncooked crustaceans. [43][44][45] Paragonimiasis is endemic in Asia (particularly Korea, Japan, Taiwan, and China), western Africa (especially Nigeria, the Congo, Cameroon, and West Africa), and South America (primarily Ecuador, Venezuela, and Peru). 43 The prevalence of skin reactivity is as high as 78% of the population in endemic areas.…”

Section: Life Cyclementioning

confidence: 99%

“…[43][44][45] Paragonimiasis is endemic in Asia (particularly Korea, Japan, Taiwan, and China), western Africa (especially Nigeria, the Congo, Cameroon, and West Africa), and South America (primarily Ecuador, Venezuela, and Peru). 43 The prevalence of skin reactivity is as high as 78% of the population in endemic areas. 46,47 Although zoonotic paragonimiasis is widespread in midwestern and eastern North America, most human cases in the United States are imported.…”

Section: Life Cyclementioning

confidence: 99%

“…46 Transpleural migration may result in pneumothorax, eosinophilic pleuritis with effusion, pleural thickening, or empyema. 43,48 Burrowing of the parasite within the lung parenchyma is associated with eosinophilic pneumonitis. The eventual settlement of the fluke in the lung produces a chronic inflammatory reaction, cavitation, and the formation of a fibrous capsule (the "worm cyst").…”

Section: Pathogenesismentioning

confidence: 99%

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