Blood glycemia-modulating effects of melanian snail protein hydrolysates in mice with type II diabetes

Choi, Jae‐Suk; Kim, Joowan; Park, Jeong Been; Pyo, Sang Eun; Hong, Y. S.; Ku, Sae Kwang; Kim, Mi-Ryung

doi:10.3892/ijmm.2017.2967

Cited by 18 publications

(64 citation statements)

References 77 publications

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“…The 50 mg/kg WL also elevated the modulation of pancreatic lipid enzyme and activation of antioxidant defense system compared to metformin 250 mg/kg ( Figure 10). An increase in the deposit of adipose tissue is a general aspect of obesity [13,14,16,31]. Adipose tissue acts as an energy storage organ, as well as an endocrine and secretory organ [38].…”

Section: Discussionmentioning

confidence: 99%

“…Hyperglycemia is the key cause and symptom of diabetes; this parameter should be regulated to treat diabetes [13,16]. HFD-fed mice have been wildly employed to study for type II diabetes; they have been shown to develop noticeable hyperglycemia [13,14,29,31]. As insulin resistance progresses to type II diabetes, enhanced levels in blood insulin and Hb1Ac have been detected after chronic intake of an HFD [44,45].…”

Section: Discussionmentioning

confidence: 99%

“…Lifestyle interventions, including exercise and weight loss, are the only established treatments for metabolic syndrome; however, these interventions are frequently hard for individuals with metabolic syndrome to maintain for extended periods [9]. Thus, patients with metabolic syndrome and experts are contemplating complementary and alternative methods [12][13][14]. There is a need to discover agents targeted at elevated hepatic lipids, which are safe for long-term administration.…”

Section: Introductionmentioning

confidence: 99%

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Anti-Diabetic Obesity Effects of Wasabia Japonica Matsum Leaf Extract on 45% Kcal High-Fat Diet-Fed Mice

Choi¹,

Kim

Lee

et al. 2020

Nutrients

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The present study examined the effects of Wasabi leaf (WL) on 45% Kcal high-fat diet (HFD)-fed mild diabetic obese mice. In particular, the hepatoprotective (i.e., liver weight, histopathology of liver, serum aspartate aminotransferase, alanine aminotransferase, and gamma-glutamyltransferase) effects of 12 weeks of continuous oral administration of 250 mg/kg metformin, and 200, 100, or 50 mg/kg WL were investigated. In addition, the hypolipidemic (i.e., serum triglyceride, total cholesterol, high-density lipoprotein-cholesterol, and low-density lipoprotein levels), hypoglycemic (i.e., glycated hemoglobin, blood glucose and insulin levels, pancreatic weight, and immunohistochemical-histopathological analysis of the pancreas), and anti-obesity effects (i.e., body weight, mean food consumption, total and abdominal body fat mass, periovarian fat weight, and histopathology of the periovarian and abdominal wall adipocytes) were monitored. The liver and general antioxidant defense systems were also assessed by lipid metabolism-related gene expression. All diabetes manifestations and related complications, including obesity and non-alcoholic fatty liver disease (NAFLD), were dose-dependently reduced after 84 days of oral treatment with metformin or each of the three dosages of WL. In particular, 50 mg/kg WL showed effective suppression effects against HFD-induced diabetes and related complications of obesity, NAFLD, and hyperlipidemia, comparable to the effects of metformin.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Anti-Diabetic Obesity Effects of Wasabia Japonica Matsum Leaf Extract on 45% Kcal High-Fat Diet-Fed Mice

Choi¹,

Kim

Lee

et al. 2020

Nutrients

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“…Differences were considered significant at p < 0.05. In addition, the percent changes between intact vehicle and OVA control mice were calculated to monitor the severities of asthmatic changes induced by OVA sensitization and boosting, and the percent changes between OVA control mice and PS + CR 300 and 1,000 mg/kg or DEXA 3 mg/kg treated mice were also calculated to help us understand the efficacy, according to our previous reports [31,32] as follows:…”

Section: Discussionmentioning

confidence: 99%

Effects of Pelargonium sidoides and Coptis Rhizoma 2 : 1 Mixed Formula (PS + CR) on Ovalbumin‐Induced Asthma in Mice

Min

Park

Choi

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Pelargonium sidoides (PS) is traditionally used to treat respiratory and gastrointestinal infections, dysmenorrhea, and hepatic disorders in South Africa. Coptis Rhizoma (CR) is used to treat gastroenteric disorders, cardiovascular diseases, and cancer in East Asia. In the present study, we intended to observe the possible beneficial antiasthma effects of PS and CR on the ovalbumin- (OVA-) induced asthma C57BL/6J mice. Asthma in mice was induced by OVA sensitization and subsequent boosting. PS + CR (300 and 1,000 mg/kg; PO) or dexamethasone (IP) was administered once a day for 16 days. The changes in the body weight and gains, lung weights and gross inspections, total and differential cell counts of leukocytes in bronchoalveolar lavage fluid (BALF), serum OVA-specific immunoglobulin E (OVA-sIgE) levels, interleukin-4 (IL-4) and IL-5 levels in BALF and lung tissue homogenate, and IL-4 and IL-5 mRNA levels in lung tissue homogenates were analyzed with lung histopathology: mean alveolar surface area (ASA), alveolar septal thickness, numbers of inflammatory cells, mast cells, and eosinophils infiltrated in the alveolar regions, respectively. Significant increases in lung weights, total and differential cell counts of leukocytes in BALF, serum OVA-sIgE levels, and IL-4 and IL-5 levels in BALF and lung tissue homogenate were observed in OVA control as compared to those of intact control. In addition, OVA control showed a significant decrease in mean ASA and increases in alveolar septal thickness, numbers of inflammatory cells, mast cells, and eosinophils infiltrated in alveolar regions. However, these allergic and inflammatory asthmatic changes were significantly inhibited by PS + CR in a dose-dependent manner. In this study, PS + CR showed dose-dependent beneficial effects on OVA-induced asthma in mice through anti-inflammatory and antiallergic activities. Therefore, it is expected that PS + CR have enough potential as a new therapeutic agent or as an ingredient of a medicinal agent for various allergic and inflammatory respiratory diseases including asthma.

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“…Furthermore, the percentage changes compared with the HFD control were estimated to improve understanding of the efficacy of the test substances. The percentage changes between the HFD and intact control groups were also determined to detect the induction of disease using the following equations in accordance with our previous studies ( 19 , 50 ).…”

Section: Methodsmentioning

confidence: 99%

Anti-obesity and fatty liver-preventing activities of Lonicera�caerulea in high-fat diet-fed mice

Kim¹,

Lee

Seol³

et al. 2018

Int J Mol Med

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Blue honeysuckle (BH, Lonicera caerulea) is used as a traditional medicine in Russia, Japan and China, but is not commonly considered as an edible berry in Europe, USA or Korea. BH has been revealed to decrease serum cholesterol and triacylglycerol (triglyceride or TG) levels through the activation of AMP-activated protein kinase (AMPK), thus it is expected to be a health functional food and pharmaceutical agent for the prevention of non-alcoholic liver damage, in addition to effects as a suppressor of hyperlipidemia and as an anti-obesity agent. In the present study, the pharmacological activity of BH extract (BHe) was observed in high-fat diet (HFD)-fed mice. Significant increases in fat pad weight, body weight, fat accumulation (body and abdominal fat density, and thickness of the periovarian and abdominal wall) and serum biochemical levels (aspartate transaminase, alanine amino-transferase, alkaline phosphatase, lactate dehydrogenase, γ-glutamyltransferase, total cholesterol, low-density lipoprotein and TG, with the exception of high-density lipoprotein) were observed in HFD-fed mice. In addition, increases in adipocyte hypertrophy, the area of steatohepatitis and hepatocyte hypertrophy were observed, whereas decreased zymogen content was identified upon histopathological observation. Increased deterioration of the endogenous antioxidant defense system (liver catalase, glutathione and superoxide dismutase) and hepatic lipid peroxidation was observed. In addition, there were decreases in hepatic glucokinase activity, AMPKα1 and AMPKα2 mRNA expression, adipose tissue uncoupling protein 2 expression, and adiponectin mRNA expression, increases in phosphoenolpyruvate carboxykinase and glucose-6-phosphatase activity, hepatic acetyl-CoA carboxylase 1 mRNA expression, and the expression of leptin, CCAAT/enhancer-binding protein (C/EBP) α, C/EBPβ and sterol-regulatory-element-binding protein 1c mRNA in the periovarian tissue. Furthermore, non-alcoholic fatty liver disease (NAFLD) and obesity were significantly inhibited by the continuous administration of BHe for 84 days. These results revealed that BHe may be a promising novel drug or functional food candidate for the treatment of obesity and NAFLD.

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Blood glycemia-modulating effects of melanian snail protein hydrolysates in mice with type II diabetes

Cited by 18 publications

References 77 publications

Anti-Diabetic Obesity Effects of Wasabia Japonica Matsum Leaf Extract on 45% Kcal High-Fat Diet-Fed Mice

Anti-Diabetic Obesity Effects of Wasabia Japonica Matsum Leaf Extract on 45% Kcal High-Fat Diet-Fed Mice

Effects of Pelargonium sidoides and Coptis Rhizoma 2 : 1 Mixed Formula (PS + CR) on Ovalbumin‐Induced Asthma in Mice

Anti-obesity and fatty liver-preventing activities of Lonicera�caerulea in high-fat diet-fed mice

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