Paragonimus and Paragonimiasis

Yokogawa, M.

doi:10.1016/s0065-308x(08)60364-4

Cited by 102 publications

(17 citation statements)

References 31 publications

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“…The southern part of Kyusyu district, Japan, has long been known as one of the major endemic areas of this disease [13,14]. The infection is acquired from the traditional custom of eating freshwater crabs, Eriocheir japonicus, a second intermediate host, or the flesh of wild boars, Susscrofa leukomystax, a proven paratenic host [17,18]. Paragonimiasis is a disease typically associated with eosinophilia and a high incidence of eosinophilic pleural effusion [1,2].…”

Section: Discussionmentioning

confidence: 99%

Elevated IL-5 levels in pleural fluid of patients with paragonimiasis westermani

Taniguchi

Mukae

Matsumoto

et al. 2001

Clinical and Experimental Immunology

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SUMMARYTo investigate the pathogenic mechanisms of eosinophilic pleural effusion in patients with paragonimiasis, we measured the levels of IL-5, granulocyte-macrophage colony-stimulating factor (GM-CSF) and interferon-gamma (IFN-g ) in pleural effusions. Samples were obtained from 11 patients with Paragonimus westermani infection. In addition, samples from 12 patients with pleural transudates, 16 with tuberculous pleurisy, seven with empyema and 20 with lung cancer were also examined. Eosinophilia was remarkable in peripheral blood (range 4±34%, median 23´4%) and pleural fluid (range 0±95%, median 71%) of paragonimiasis patients. IL-5 concentrations in pleural effusions of paragonimiasis were markedly higher than those in other groups. Although marked elevation of GM-CSF and IFN-g levels was observed in pleural effusion of empyema and tuberculosis patients, it was marginal in the pleural effusion of paragonimiasis patients. In paragonimiasis patients, IL-5 levels in the pleural effusion correlated well with the percentage of eosinophils in peripheral blood and pleural fluid. Such a correlation was not observed between GM-CSF levels in pleural effusion and percentages of eosinophils in pleural fluid or peripheral blood. Our findings suggest that in paragonimiasis IL-5 in the local inflammatory site is particularly important in mediating eosinophilia in peripheral blood and pleural effusion.

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Section: Discussionmentioning

confidence: 99%

Elevated IL-5 levels in pleural fluid of patients with paragonimiasis westermani

Taniguchi

Mukae

Matsumoto

et al. 2001

Clinical and Experimental Immunology

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“…The southern part of Kyusyu district, Japan has long been known as one of the major endemic areas of this disease [1][2][3]. In Japan, infection is acquired through eating freshwater crab, Eriocheir japonicus , the second intermediate host, or the flesh of wild boars, Sus scrofa leukomystax , a proven paratenic host [4,5]. Paragonimiasis is a disease associated typically with peripheral blood eosinophilia and a high incidence of eosinophilic pleural effusion [1,2].…”

Section: Introductionmentioning

confidence: 99%

Elevated levels of thymus and activation-regulated chemokine (TARC) in pleural effusion samples from patients infested withParagonimus westermani

Matsumoto¹,

Mukae

Nakamura‐Uchiyama

et al. 2002

Clinical and Experimental Immunology

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SUMMARYTo investigate the pathogenic mechanisms of eosinophilic pleural effusion in patients with paragonimiasis, we measured the levels of various chemokines including thymus and activation-regulated chemokine (TARC), eotaxin, RANTES and IL-8 in pleural effusion samples. Samples were obtained from 11 patients with Paragonimus westermani infection, six patients with pleural transudate, eight with tuberculous pleurisy and five with empyema. High percentages of eosinophils were detected in pleural fluid (range 9-100%, median 81%) of patients with paragonimiasis. TARC concentrations in pleural effusions of paragonimiasis were markedly higher than those of other groups. Eotaxin levels were also higher in pleural effusions of paragonimiasis patients, although significant difference was noted only against transudate samples. There was a significant correlation between TARC concentrations and percentages of eosinophils, and between TARC and eotaxin concentrations in pleural effusion. There were also significant correlations between TARC concentration and the titre of anti-P. westermani IgG and between eotaxin concentration and the titre of anti-P. westermani IgG. Our findings suggest that TARC contributes to the pathogenesis of eosinophilic pleural effusion in paragonimiasis.

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“…Según Ando y Nakagawa (Cit. por Yokogawa, 1965), a 55 Q C por 20 minutos, murieron todas las metacer carias en el cuerpo del cangrejo; resistie ron por más de 24 horas en vinagre, azúcar, sal y "sake-kasu". Si se congelan por cierto tiempo y se calienta lentamen te, recuperan su actividad.…”

Section: Discusionunclassified

Paragonimus y Paragonimiasis en el norte peruano. Proceso del desarrollo de Paragonimus peruvianus Miyazaki¡ Ibañez y Miranda¡ 1969 en Felis cati L. gato doméstico infectado experimentalmente.

et al. 1974

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Paragonimus and Paragonimiasis

Cited by 102 publications

References 31 publications

Elevated IL-5 levels in pleural fluid of patients with paragonimiasis westermani

Elevated IL-5 levels in pleural fluid of patients with paragonimiasis westermani

Elevated levels of thymus and activation-regulated chemokine (TARC) in pleural effusion samples from patients infested withParagonimus westermani

Paragonimus y Paragonimiasis en el norte peruano. Proceso del desarrollo de Paragonimus peruvianus Miyazaki¡ Ibañez y Miranda¡ 1969 en Felis cati L. gato doméstico infectado experimentalmente.

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