Elevated levels of thymus and activation-regulated chemokine (TARC) in pleural effusion samples from patients infested with<i>Paragonimus westermani</i>

Matsumoto, Nobuhiro; Mukae, Hiroshi; Nakamura‐Uchiyama, Fukumi; Ashitani, Jun‐ichi; Abe, Koh; Katoh, Shigeki; Kohno, Shigeru; Nawa, Yukifumi; Matsukura, Shigeru

doi:10.1046/j.1365-2249.2002.01985.x

Cited by 16 publications

(9 citation statements)

References 22 publications

(26 reference statements)

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“…Increased levels of CCL17/TARC also paralleled increasing eosinophil counts in peripheral blood of TB patients, a finding similar to those of a previous report about pleural effusion (19). Eosinophils can mediate antibody-dependent cellular cytotoxicity and interact closely with Th2-type CD4 ϩ T cells in mediating cytokine production, chemokine receptor expression, and cellular influx into the respiratory tract.…”

Section: Discussionsupporting

confidence: 76%

Elevated Serum Levels of CCL17 Correlate with Increased Peripheral Blood Platelet Count in Patients with Active Tuberculosis in China

Feng

Yin

Mai

et al. 2011

Clin. Vaccine Immunol.

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Active tuberculosis (TB) has been associated with imbalance of Th1 and Th2 cytokine pattern. Activation of Th1 lymphocytes, gamma interferon (IFN-␥) production and macrophage activation are crucial in defense against mycobacteria, while Th2 activation and interleukin-4 (IL-4) production are associated with TB progressing and with poor clinical outcome after treatment (6).After being secreted, IFN-␥ and IL-4 are rapidly bound by their receptors and/or inactivated by proteases, which leads to difficulty in detecting these two typical Th1/Th2 cytokines in plasma or serum (26). Therefore, other markers have been investigated as alternative indicators of preferential Th1 or Th2 activity in vivo.CCL17 (thymus and activation-regulated chemokine [TARC]) and CCL22 (macrophage-derived chemokine [MDC]) are two specific chemotactic factors for Th2 cells (12). CD30, a tumor necrosis factor (TNF) receptor II family member, is also correlated with Th2 activation (3). sCD30 is a soluble form of CD30, which is generated by proteolytic cleavage of the extracellular portion of this transmembrane molecule and can be measured in serum or plasma by enzyme-linked immunosorbent assay (ELISA). Previous reports indicate increasing expression of these factors in patients with Th2 bias status, such as asthma (27), arthritis (7), and lymphoma (2); however, very few reports examine the changes in these Th2 factors in TB patients (16).For screening of new Th2 markers in active TB patients, we compared the serum levels of CCL17/TARC, CCL22/MDC, and sCD30 in HIV-negative TB patients with samples obtained from community healthy controls in China. The results indicate that CCL17/TARC and sCD30 might be more suitable as serum Th2 marker than CCL22/MDC in active TB patients. The correlation of these Th2 markers and the platelet and eosinophil counts in peripheral blood were also analyzed. MATERIALS AND METHODSStudy subjects. Peripheral blood was obtained from 103 normal healthy subjects, 101 active pulmonary TB patients, and 18 TB patients in recovery. The age and sex information of patients and controls are presented in Table 1. The patients included were clinically and radiologically diagnosed for pulmonary TB, and diagnoses confirmed by sputum smear and culture for Mycobacterium tuberculosis. The patients were recruited from the clinics of Shanghai Pulmonary Hospital. All of the patients were HIV negative; none of them presented with other infectious diseases or immunosuppressive conditions. All of the active TB patients received anti-TB therapy for less than 1 week and were classified into three categories (5): mild TB was defined by the presence of scattered and nonconfluent pulmonary infiltrates of slight to moderate density in one or both lungs, with the total volume less than one lung, without cavities. Moderate TB was defined by scattered and nonconfluent pulmonary infiltrates present in one or both lungs and/or with dense and confluent lesions but not involving more than one-third of the volume of one lung, with or without cavities with a...

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Section: Discussionsupporting

confidence: 76%

Elevated Serum Levels of CCL17 Correlate with Increased Peripheral Blood Platelet Count in Patients with Active Tuberculosis in China

Feng

Yin

Mai

et al. 2011

Clin. Vaccine Immunol.

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“…Actuary TARC concentration was elevated in serum of patients with Pw compared with healthy subjects. Furthermore, we have recently reported elevated TARC concentration in pleural effusion of patients with Pw [19]. We found increased percentages of CCR4+ Th2 cells in the circulation (fig.…”

Section: Discussionmentioning

confidence: 49%

“…Peripheral blood eosinophilia and a high incidence of eosinophilic pleural effusion are observed in patients with Pw [6, 15]. Furthermore, we have recently reported the presence of high concentrations of IL-5 and TARC in pleural effusion of patients with Pw [9, 19]. Although P. westermani infection might induce Th2-dominant responses in humans, there is only a case report that it affects the immune response [20].…”

Section: Discussionmentioning

confidence: 99%

A Possible Role of TARC in Antigen-Specific Th2-Dominant Responses in Patients with Paragonimiasis westermani

Katoh

Matsumoto²,

Matsumoto³

et al. 2004

Int Arch Allergy Immunol

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Background: Paragonimiasis westermani (Pw), a common parasitic zoonosis in Asia, is typically associated with eosinophilia. Th2 cytokines seem to have an important role in the clinical manifestations of this disease. Thymus and activation-regulated chemokine (TARC) is a potential key regulator of Th2-mediated inflammation. The purpose of the present study was to evaluate the antigen-specific Th2-dominant responses in patients with Pw. Methods: The concentrations of cytokines and chemokines in supernatants of peripheral blood mononuclear cell (PBMC) cultures with or without antigen stimulation were measured by enzyme-linked immunosorbent assay (ELISA). TARC levels in serum from Pw patients were also evaluated by ELISA. The number of Th2 cells expressing the CC-chemokine receptor 4 (CCR4) in the peripheral blood was evaluated by flow cytometry. Results: Antigen-stimulation induced production of IL-5 and IL-13, but not IFN-γ from PBMC cultures in patients with Pw. Pw patients had elevated serum TARC levels and a higher proportion of CCR4-expressing cells among CD4+ T cells in the peripheral blood. There were also higher levels of TARC, but not IP-10, in supernatants of antigen-stimulated PBMC culture compared to unstimulated PBMC culture in patients with Pw. Conclusion: Our findings clarify antigen-specific Th2-dominant responses in patients with Pw and suggest a possible role for TARC in Th2-dominant responses.

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“…In another human trematode infection, increased CCL11 and CCL17 concentrations were also detected in pleural effusion samples from individuals infected with Paragonimus westermani (Matsumoto et al . ). Serum concentrations of inflammatory cytokines, such as IL‐1β and IL‐6, were low and only up to 20% of participants in each group were considered as responders.…”

Section: Discussionmentioning

confidence: 99%

Serum CCL11 (eotaxin‐1) and CCL17 (TARC) are serological indicators of multiple helminth infections and are driven by Schistosoma mansoni infection in humans

Geiger

Jardim-Botelho

Williams

et al. 2013

Tropical Med Int Health

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Abstractobjectives To evaluate systemic serum cytokine and chemokine markers for inflammation and Th1/ Th2 responses in relation to multiple helminth infections, parasite burden and/or nutritional status of individuals.methods In a longitudinal study, stool samples from 210 individuals from an area highly endemic for Ascaris lumbricoides, Necator americanus and Schistosoma mansoni were examined before and 12 months after clearance of parasites by chemotherapy. On both occasions, the presence of monoor multiple infections and intensities of infection were compared with nutritional parameters and with serum cytokines or chemokines as markers for inflammatory, regulatory or Th1-or Th2-type immune responses.results Before treatment, we were not able to associate any altered nutritional parameters with increased inflammatory responses, and highest intensities of infection were found in eutrophic participants with multiple infections. In contrast, major changes in serum Th2-type chemokine levels were measured in individuals infected with intestinal helminths and/or S. mansoni, and resulted in significantly higher CCL11 and CCL17 concentrations, both before treatment and after reinfection.conclusions The driving force for these elevated type 2 serum chemokine concentrations was an S. mansoni infection and faecal egg counts significantly correlated with serum IL-10 concentrations.

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Elevated levels of thymus and activation-regulated chemokine (TARC) in pleural effusion samples from patients infested withParagonimus westermani

Cited by 16 publications

References 22 publications

Elevated Serum Levels of CCL17 Correlate with Increased Peripheral Blood Platelet Count in Patients with Active Tuberculosis in China

Elevated Serum Levels of CCL17 Correlate with Increased Peripheral Blood Platelet Count in Patients with Active Tuberculosis in China

A Possible Role of TARC in Antigen-Specific Th2-Dominant Responses in Patients with Paragonimiasis westermani

Serum CCL11 (eotaxin‐1) and CCL17 (TARC) are serological indicators of multiple helminth infections and are driven by Schistosoma mansoni infection in humans

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