Paradoxical visuomotor adaptation to reversed visual input is predicted by BDNF Val66Met polymorphism

Barton, Brian; Treister, Andrew; Humphrey, Melanie; Abedi, Garen; Cramer, Steven C.; Brewer, Alyssa A.

doi:10.1167/14.9.4

Cited by 11 publications

(8 citation statements)

References 45 publications

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“…Similar to some previous reports (Barton et al, 2014; Erickson et al, 2008; Gajewski et al, 2011; Getzmann et al, 2013), we found paradoxical results for the BDNF met allele in relation to behavior. That is, we found that BDNF met homozygotes performed superior to the val allele carriers in the sequence learning task.…”

Section: Resultssupporting

confidence: 87%

Interactive effects of age and multi-gene profile on motor learning and sensorimotor adaptation

et al. 2016

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The interactive association of age and dopaminergic polymorphisms on cognitive function has been studied extensively. However, there is limited research on whether age interacts with the association between genetic polymorphisms and motor learning. We examined a group of young and older adults’ performance in three motor tasks: explicit sequence learning, visuomotor adaptation, and grooved pegboard. We assessed whether individuals’ motor learning and performance were associated with their age and genotypes. We selected three genetic polymorphisms: Catechol-O-Methyl Transferase (COMT val158met) and Dopamine D2 Receptor (DRD2 G > T), which are involved with dopaminergic regulation, and Brain Derived Neurotrophic Factor (BDNF val66met) that modulates neuroplasticity and has been shown to interact with dopaminergic genes. Although the underlying mechanisms of the function of these three genotypes are different, the high performance alleles of each have been linked to better learning and performance. We created a composite polygene score based on the Number of High Performance Alleles (NHPA) that each individual carried. We found several associations between genetic profile, motor performance, and sensorimotor adaptation. More importantly, we found that this association varies with age, task type, and engagement of implicit versus explicit learning processes.

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Section: Resultssupporting

confidence: 87%

Interactive effects of age and multi-gene profile on motor learning and sensorimotor adaptation

et al. 2016

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“…To the best of our knowledge, this is the first study analysing the association between a specific genetic variant (BDNF rs6265) and sensorimotor adaptation that is based on perceptual and cognitive factors in gross motor skills. In previous studies, sensorimotor adaptability referred mainly to visuomotor tasks, and fine rather than gross motor skills, such as tracking moving objects (Gonzalez-Giraldo et al, 2016;Joundi et al, 2012), finger tapping and pegboard scores (Kleim et al, 2006), or using goggles that left-right mirror-reversed the subject's field of view (Barton et al, 2014). Several studies have shown an association between the c.196G>A (p.Val66Met) BDNF polymorphism and impaired perceptual and cognitive function, such as the working memory network, spatial localization, attention and perceptual speed, where the Met allele (A allele) carriers presented higher deficits and reduced hippocampal activity (Schofield et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

“…The BDNF rs6265 (c.196G>A) polymorphism, which results in a change of valine (Val) to methionine (Met) at amino acid position 66 (p.Val66Met) of the BDNF protein, was associated with impaired activitydependent secretion of this neurotrophin (Egan et al, 2003). The results of previous studies have suggested that the BDNF rs6265 polymorphism has an inhibitory effect on sensorimotor adaptability in fine motor skills; however, those experimental findings were not conclusive (Barton et al, 2014;Gonzalez-Giraldo et al, 2016;Joundi et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Contributing Factors to Sensorimotor Adaptability in Reactive Agility Performance in Youth Athletes

Zwierko¹,

Nowakowska²,

Jedziniak³

et al. 2022

Journal of Human Kinetics

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Sensorimotor adaptability facilitates adjusting behaviour for changing environmental stimuli to maintain appropriate goal-directed motor performance. Its effectiveness is associated with perceptual-cognitive modulation. As the factors affecting it are still not completely known, the aim of our study was therefore to analyse the association between selected variables (demographic, training, anthropometric, genetic) and sensorimotor adaptation in reactive agility tasks in youth team-sport athletes. The study group consisted of 85 youth athletes (aged 12.61 ± 0.98 years). Based on an initial evaluation, participants were divided into faster and slower agility groups. The resultant differences between change of direction speed tests and reactive agility tests provided the REAC-INDEX as a dependent variable. The independent variables were as follows: gender, calendar age, body mass, height, BMI, maturity offset, training status and the BDNF rs6265 polymorphism. Multiple linear regression showed that the maturity offset (ß = 0.269; p = 0.012) and calendar age (ß = -0.411; p < 0.001) significantly contributed to the REAC-INDEX of all participants (R2 = 0.13). In the slower group, the c.196G BDNF allele had a significant influence (ß = -0.140; p = 0.044) on the REAC-INDEX. The best predictive model comprised female gender (ß = 0.799; p < 0.001), maturity offset (ß = -0.586; p < 0.001) and training experience (ß = -0.225; p = 0.009), contributing to 49% of RA variance. Sensorimotor adaptability is mainly dependent on gender and age, and can be improved through systematic sports training. The BDNF rs6265 polymorphism may be considered a contributing factor to SA variability in the initial stages of training, although polymorphism-related differences blurred as the effect of participation in sports training increased.

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“…Little is known about individual differences in adaptation, though observers consistently differ in the magnitude and pattern of aftereffects (Elliott et al, 2012, Vera-Diaz et al, 2010), and some of these differences may reflect polymorphisms in the genes coding neurotrophins (Barton et al, 2014). Adaptation also varies over the lifespan.…”

Section: Adaptation and Compensationmentioning

confidence: 99%

Visual Adaptation

Webster

2015

Annu. Rev. Vis. Sci.

305

291

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Sensory systems continuously mold themselves to the widely varying contexts in which they must operate. Studies of these adaptations have played a long and central role in vision science. In part this is because the specific adaptations remain a powerful tool for dissecting vision, by exposing the mechanisms that are adapting. That is, “if it adapts, it's there.” Many insights about vision have come from using adaptation in this way, as a method. A second important trend has been the realization that the processes of adaptation are themselves essential to how vision works, and thus are likely to operate at all levels. That is, “if it's there, it adapts.” This has focused interest on the mechanisms of adaptation as the target rather than the probe. Together both approaches have led to an emerging insight of adaptation as a fundamental and ubiquitous coding strategy impacting all aspects of how we see.

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Paradoxical visuomotor adaptation to reversed visual input is predicted by BDNF Val66Met polymorphism

Cited by 11 publications

References 45 publications

Interactive effects of age and multi-gene profile on motor learning and sensorimotor adaptation

Interactive effects of age and multi-gene profile on motor learning and sensorimotor adaptation

Contributing Factors to Sensorimotor Adaptability in Reactive Agility Performance in Youth Athletes

Visual Adaptation

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