Paradoxical effects of elastase inhibitor guamerin on the tissue repair of two different wound models: sealed cutaneous and exposed tongue wounds

Neutrophils and Wound Repair: Positive Actions and Negative Reactions

“…20 This idea is supported by a study showing that the elastase inhibitor gramerin accelerates re-epithelialization rates. 21 In this study, inflammation was also reduced in gramerin-treated wounds, suggesting a role for elastase in the regulation of wound inflammation. 21 Similarly, high elastase levels have been observed in chronic wounds.…”

“…21 In this study, inflammation was also reduced in gramerin-treated wounds, suggesting a role for elastase in the regulation of wound inflammation. 21 Similarly, high elastase levels have been observed in chronic wounds. 22,23 Interestingly, elastase can also activate other classes of proteases (i.e., MMPs) [24][25][26] and inactivate protease inhibitors, 27 which could increase the total protease activity in a wound and further exacerbate host tissue damage.…”

Roles of TNF-α and IgE in the late phase of contact hypersensitivity induced by trimellitic anhydride

“…Specimens were fixed in 10% neutral buffered formalin, embedded in paraffin, cut in 4 µm section by microtome (SM 2000R, Leica, Germany; Lee et al, 2004). The sections were stained with Wright Giemsa solution for polymorpholeukocytes (Stern et al, 1997) and Congo red solution for eosinophils (Song et al, 1999).…”

The effects of a new human leukocyte elastase inhibitor (recombinant guamerin) on cerulein-induced pancreatitis in rats

“…Recombinant guamerin had paradoxical effects on tissue repair of two different septic ad aseptic wound models [31]. In aseptic wound model, the recombinant guamerin accelerated wound healing by inhibiting the inflammation-generated protease and acute inflammatory reaction.…”