Neutrophils and Wound Repair: Positive Actions and Negative Reactions

Wilgus, Traci A.; Roy, Sashwati; McDaniel, Jodi C.

doi:10.1089/wound.2012.0383

Cited by 442 publications

(398 citation statements)

References 46 publications

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“…31 Importantly, human burn wounds exhibit acute local inflammation characterized by the presence of inflammatory mediators (such as complement, CRP, neutrophils) up to 46 days postinjury. 32 In our study, histopathologic and immunohistochemistry analyses revealed that local and topical spray delivery of ADRCs reduced neutrophil infiltration within the burn wounds at 7 days posttreatment. These data are consistent with other studies that suggest a role for ADRCs in reducing local inflammation.…”

Section: Discussionsupporting

confidence: 55%

Adipose-Derived Regenerative Cell Therapy for Burn Wound Healing: A Comparison of Two Delivery Methods

Foubert

Gonzalez

Teodosescu

et al. 2016

Advances in Wound Care

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Section: Discussionsupporting

confidence: 55%

Adipose-Derived Regenerative Cell Therapy for Burn Wound Healing: A Comparison of Two Delivery Methods

Foubert

Gonzalez

Teodosescu

et al. 2016

Advances in Wound Care

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“…They function in preventing bacterial infection (given the disrupted epithelial barrier) as well as in activation of keratinocytes, fibroblasts and immune cells. (34,35) Early migration of keratinocytes along the temporary fibrin ECM is seen within hours of wounding. (10) Circulating monocytes arrive and differentiate into macrophages 2-3 days after the injury.…”

Section: Introductionmentioning

confidence: 99%

Stem Cell Therapy in Wound Healing and Tissue Regeneration

2016

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BACKGROUND: Recent advances in our basic knowledge of the tissue damage and regeneration pathology have combined with a remarkable progress in stem cell biology so the prospect of clinical tissue repair strategies is a tangible reality. We tried to describe a better view about mesenchymal stem cell (MSC) mechanisms in wound healing and tissue regeneration, sending any ideas for next advanced therapies.CONTENT: Sustaining injury, whether minor or major, is part of every organism life. Therefore, efficient response mechanisms to damage have developed. Wound healing is a perplexing multi-step processes which can be divided into three major phases: inflammation, proliferation, and scar formation/remodeling. Though the compartementalization of this process into discrete stages give the illusion of simplicity, but in reality it is much more complicated. So that efficient healing can occur, complex interactions between multiple cell types, soluble factors and extracellular matrix components are required to rebuild the tissue. Even under optimal conditions, the healing process drives to fibrosis or scar. The latest technology that makes a huge difference in the wound healing process is stem cell therapy, which offers a novel approach to many diseases.SUMMARY: Wound healing therapies continue to rapidly evolve, with advances in basic science and engineering research heralding the development of new therapies, as well as ways to modify existing treatments. Stem cell-based therapy is one of the most promising therapeutic concepts for wound healing. Advances in stem cell biology have enabled researchers and clinicians alike with access to cells capable of actively modulating the healing response. KEYWORDS: wound healing, tissue regeneration, stem cells therapy

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“…71,72 The underlying pathological processes involved in chronic wound recalcitrance means that chronic exudate is highly damaging to tissues with its high content of protein-degrading enzymes. 73 Whilst proteases are necessary for normal wound healing, 74 the highly inflamed nature of the chronic wound bed is partly as a result of elevated and uncontrolled levels of proteases such as matrix metalloproteases, 75,76 neutrophil elastase 73,77,78 and pro-inflammatory cytokines in chronic wound exudate. 79 The combined presence of these corrosive components within chronic wound fluid leads to damage of the ulcer bed and wound margin.…”

Section: Exudate-dependent Tissue Damagementioning

confidence: 99%

The importance of hydration in wound healing: reinvigorating the clinical perspective

Ousey

Cutting

Rogers³

et al. 2016

J Wound Care

135

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Balancing skin hydration levels is important as any disruption in skin integrity will result in disturbance of the dermal water balance. The discovery that a moist environment actively supports the healing response when compared with a dry environment highlights the importance of water and good hydration levels for optimal healing. The benefits of ‘wet’ or ‘hyper-hydrated’ wound healing appear similar to those offered by moist over a dry environment. This suggests that the presence of free water may not be detrimental to healing, but any adverse effects of wound fluid on tissues is more likely related to the biological components contained within chronic wound exudate, for example elevated protease levels. Appropriate dressings applied to wounds must not only be able to absorb the exudate, but also retain this excess fluid together with its protease solutes, while concurrently preventing desiccation. This is particularly important in the case of chronic wounds where peri-wound skin barrier properties are compromised and there is increased permeation across the injured skin. This review discusses the importance of appropriate levels of hydration in skin, with a particular focus on the need for optimal hydration levels for effective healing. Declaration of interest: This paper was supported by Paul Hartmann Ltd. The authors have provided consultative services to Paul Hartmann Ltd.

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Neutrophils and Wound Repair: Positive Actions and Negative Reactions

Cited by 442 publications

References 46 publications

Adipose-Derived Regenerative Cell Therapy for Burn Wound Healing: A Comparison of Two Delivery Methods

Adipose-Derived Regenerative Cell Therapy for Burn Wound Healing: A Comparison of Two Delivery Methods

Stem Cell Therapy in Wound Healing and Tissue Regeneration

The importance of hydration in wound healing: reinvigorating the clinical perspective

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